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Protein

Putative tyrosine-protein phosphatase OCA1

Gene

OCA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative tyrosine-protein phosphatase required for protection against superoxide stress. Involved in cell-cycle delay in response to linoleic acid hydroperoxide (LoaOOH).3 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciYEAST:G3O-33127-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tyrosine-protein phosphatase OCA1 (EC:3.1.3.48)
Alternative name(s):
Oxidant-induced cell-cycle arrest protein 1
Gene namesi
Name:OCA1
Ordered Locus Names:YNL099C
ORF Names:N2194
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL099C.
SGDiS000005043. OCA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002034392 – 238Putative tyrosine-protein phosphatase OCA1Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei24PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP50946.
PRIDEiP50946.

PTM databases

iPTMnetiP50946.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
OCA2P539495EBI-28814,EBI-28725
SIW14P539654EBI-28814,EBI-28668

Protein-protein interaction databases

BioGridi35724. 123 interactors.
DIPiDIP-1991N.
IntActiP50946. 5 interactors.
MINTiMINT-406344.

Structurei

3D structure databases

ProteinModelPortaliP50946.
SMRiP50946.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00530000066535.
HOGENOMiHOG000188365.
InParanoidiP50946.
KOiK18043.
OMAiNAWDPIT.
OrthoDBiEOG092C4JKC.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR004861. Tyr_Pase_SIW14-like.
[Graphical view]
PfamiPF03162. Y_phosphatase2. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKVGEYED VPEDESRLTE ENVSVPEEEV EDEDEEEDDD DDHIYINEET
60 70 80 90 100
ESGREKVLVS HAPQERIVPP LNFCPVERYL YRSGQPSPVN FPFLLNLKLK
110 120 130 140 150
TIIWLSNEEP QDTLLEFCDT HRINLQFAAI NPDAGEDDNP WDGLTEHSII
160 170 180 190 200
NVLQTIVTQE NYPLLVCCGM GRHRTGTVIG CLRRIMGWNL ASVSEEYRRF
210 220 230
TGSRGGRILV ELLIEAFDTN LVKIDKNKAP SWLLTALE
Length:238
Mass (Da):27,205
Last modified:October 1, 1996 - v1
Checksum:i114DD87CBA2FAEBF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti66R → C in strain: SK1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115393 Genomic DNA. Translation: AAZ22508.1.
Z50161 Genomic DNA. Translation: CAA90527.1.
Z71375 Genomic DNA. Translation: CAA95975.1.
BK006947 Genomic DNA. Translation: DAA10446.1.
PIRiS58253.
RefSeqiNP_014300.3. NM_001182937.3.

Genome annotation databases

EnsemblFungiiYNL099C; YNL099C; YNL099C.
GeneIDi855624.
KEGGisce:YNL099C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115393 Genomic DNA. Translation: AAZ22508.1.
Z50161 Genomic DNA. Translation: CAA90527.1.
Z71375 Genomic DNA. Translation: CAA95975.1.
BK006947 Genomic DNA. Translation: DAA10446.1.
PIRiS58253.
RefSeqiNP_014300.3. NM_001182937.3.

3D structure databases

ProteinModelPortaliP50946.
SMRiP50946.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35724. 123 interactors.
DIPiDIP-1991N.
IntActiP50946. 5 interactors.
MINTiMINT-406344.

PTM databases

iPTMnetiP50946.

Proteomic databases

MaxQBiP50946.
PRIDEiP50946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL099C; YNL099C; YNL099C.
GeneIDi855624.
KEGGisce:YNL099C.

Organism-specific databases

EuPathDBiFungiDB:YNL099C.
SGDiS000005043. OCA1.

Phylogenomic databases

GeneTreeiENSGT00530000066535.
HOGENOMiHOG000188365.
InParanoidiP50946.
KOiK18043.
OMAiNAWDPIT.
OrthoDBiEOG092C4JKC.

Enzyme and pathway databases

BioCyciYEAST:G3O-33127-MONOMER.

Miscellaneous databases

PROiP50946.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR004861. Tyr_Pase_SIW14-like.
[Graphical view]
PfamiPF03162. Y_phosphatase2. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOCA1_YEAST
AccessioniPrimary (citable) accession number: P50946
Secondary accession number(s): D6W180, Q45U02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2310 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.