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Protein

Putative tyrosine-protein phosphatase OCA1

Gene

OCA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative tyrosine-protein phosphatase required for protection against superoxide stress. Involved in cell-cycle delay in response to linoleic acid hydroperoxide (LoaOOH).3 Publications

Miscellaneous

Present with 2310 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  • cellular response to oxidative stress Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processStress response

Enzyme and pathway databases

BioCyciYEAST:G3O-33127-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tyrosine-protein phosphatase OCA1 (EC:3.1.3.48)
Alternative name(s):
Oxidant-induced cell-cycle arrest protein 1
Gene namesi
Name:OCA1
Ordered Locus Names:YNL099C
ORF Names:N2194
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL099C
SGDiS000005043 OCA1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002034392 – 238Putative tyrosine-protein phosphatase OCA1Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei24PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP50946
PaxDbiP50946
PRIDEiP50946

PTM databases

iPTMnetiP50946

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35724, 254 interactors
DIPiDIP-1991N
IntActiP50946, 5 interactors
MINTiP50946
STRINGi4932.YNL099C

Structurei

3D structure databases

ProteinModelPortaliP50946
SMRiP50946
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00530000066535
HOGENOMiHOG000188365
InParanoidiP50946
KOiK18043
OMAiLLVCCGM
OrthoDBiEOG092C4JKC

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR004861 Siw14-like
PfamiView protein in Pfam
PF03162 Y_phosphatase2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKVGEYED VPEDESRLTE ENVSVPEEEV EDEDEEEDDD DDHIYINEET
60 70 80 90 100
ESGREKVLVS HAPQERIVPP LNFCPVERYL YRSGQPSPVN FPFLLNLKLK
110 120 130 140 150
TIIWLSNEEP QDTLLEFCDT HRINLQFAAI NPDAGEDDNP WDGLTEHSII
160 170 180 190 200
NVLQTIVTQE NYPLLVCCGM GRHRTGTVIG CLRRIMGWNL ASVSEEYRRF
210 220 230
TGSRGGRILV ELLIEAFDTN LVKIDKNKAP SWLLTALE
Length:238
Mass (Da):27,205
Last modified:October 1, 1996 - v1
Checksum:i114DD87CBA2FAEBF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti66R → C in strain: SK1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115393 Genomic DNA Translation: AAZ22508.1
Z50161 Genomic DNA Translation: CAA90527.1
Z71375 Genomic DNA Translation: CAA95975.1
BK006947 Genomic DNA Translation: DAA10446.1
PIRiS58253
RefSeqiNP_014300.3, NM_001182937.3

Genome annotation databases

EnsemblFungiiYNL099C; YNL099C; YNL099C
GeneIDi855624
KEGGisce:YNL099C

Similar proteinsi

Entry informationi

Entry nameiOCA1_YEAST
AccessioniPrimary (citable) accession number: P50946
Secondary accession number(s): D6W180, Q45U02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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