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Protein

MICOS complex subunit MIC27

Gene

MIC27

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.2 Publications

GO - Biological processi

  • cristae formation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33128-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC27
Alternative name(s):
Altered inheritance of mitochondria protein 37
Mitochondrial contact site complex 27 kDa subunit
Gene namesi
Name:MIC27
Synonyms:AIM37, MCS27
Ordered Locus Names:YNL100W
ORF Names:N2190
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL100W.
SGDiS000005044. MIC27.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 100Mitochondrial intermembraneSequence analysisAdd BLAST100
Transmembranei101 – 120HelicalSequence analysisAdd BLAST20
Topological domaini121 – 141Mitochondrial matrixSequence analysisAdd BLAST21
Transmembranei142 – 161HelicalSequence analysisAdd BLAST20
Topological domaini162 – 234Mitochondrial intermembraneSequence analysisAdd BLAST73

GO - Cellular componenti

  • MICOS complex Source: SGD
  • mitochondrial crista junction Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002034381 – 234MICOS complex subunit MIC27Add BLAST234

Proteomic databases

MaxQBiP50945.
PRIDEiP50945.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.1 Publication

Protein-protein interaction databases

BioGridi35723. 20 interactors.
DIPiDIP-2042N.
IntActiP50945. 9 interactors.
MINTiMINT-565064.

Structurei

3D structure databases

ProteinModelPortaliP50945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP50945.
KOiK17789.
OMAiNILTICA.
OrthoDBiEOG092C4723.

Sequencei

Sequence statusi: Complete.

P50945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNFYDDVDE SKSHGEFPLI PVVLQNSSEL SVRTIPTGNE IIESVHLTKW
60 70 80 90 100
LRKYRNALAS QLDRYEKGWQ SKIANFRLQV QHVINYSRKN IFNVDSENKH
110 120 130 140 150
TVVPGSLIAL GAFFAGSIAV NRSNWGAKRL IFGHKSSILE KLCTSLPSRI
160 170 180 190 200
LLPWVLAAAT FKYWAPQTSQ NLVNATENDL LPADFVKSYH NTWKRIYEEG
210 220 230
YVAKKCDLKR QIDQTLQKNI RYAREQLYEK LEQA
Length:234
Mass (Da):26,960
Last modified:October 1, 1996 - v1
Checksum:i8DFD8FD42E71B8DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115393 Genomic DNA. Translation: AAZ22507.1.
Z50161 Genomic DNA. Translation: CAA90526.1.
Z71376 Genomic DNA. Translation: CAA95976.1.
AY692704 Genomic DNA. Translation: AAT92723.1.
BK006947 Genomic DNA. Translation: DAA10445.1.
PIRiS58252.
RefSeqiNP_014299.1. NM_001182938.1.

Genome annotation databases

EnsemblFungiiYNL100W; YNL100W; YNL100W.
GeneIDi855623.
KEGGisce:YNL100W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115393 Genomic DNA. Translation: AAZ22507.1.
Z50161 Genomic DNA. Translation: CAA90526.1.
Z71376 Genomic DNA. Translation: CAA95976.1.
AY692704 Genomic DNA. Translation: AAT92723.1.
BK006947 Genomic DNA. Translation: DAA10445.1.
PIRiS58252.
RefSeqiNP_014299.1. NM_001182938.1.

3D structure databases

ProteinModelPortaliP50945.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35723. 20 interactors.
DIPiDIP-2042N.
IntActiP50945. 9 interactors.
MINTiMINT-565064.

Proteomic databases

MaxQBiP50945.
PRIDEiP50945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL100W; YNL100W; YNL100W.
GeneIDi855623.
KEGGisce:YNL100W.

Organism-specific databases

EuPathDBiFungiDB:YNL100W.
SGDiS000005044. MIC27.

Phylogenomic databases

InParanoidiP50945.
KOiK17789.
OMAiNILTICA.
OrthoDBiEOG092C4723.

Enzyme and pathway databases

BioCyciYEAST:G3O-33128-MONOMER.

Miscellaneous databases

PROiP50945.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMIC27_YEAST
AccessioniPrimary (citable) accession number: P50945
Secondary accession number(s): D6W179, Q45U03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.