P50945 (AIM37_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Altered inheritance of mitochondria protein 37, mitochondrial

Gene names

Name:	AIM37
Ordered Locus Names:	YNL100W
ORF Names:	N2190

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	As a component of the mitochondrial inner membrane organizing system (MINOS/MitOS) complex, important for normal mitochondrial morphology. Ref.8 Ref.11 Ref.12
Subunit structure	Component of the MINOS/MitOS complex, that includes FCJ1, AIM5, AIM13, AIM37, MOS1 and MOS2.
Subcellular location	Mitochondrion inner membrane; Single-pass membrane protein Ref.6 Ref.9 Ref.11 Ref.12.
Disruption phenotype	Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane. Ref.10 Ref.11 Ref.12
Sequence similarities	Belongs to the AIM37 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cristae formation Inferred from mutant phenotype Ref.11Ref.12PubMed 22009199. Source: SGD
Cellular_component	integral to mitochondrial inner membrane Inferred from direct assay Ref.11Ref.12PubMed 22009199. Source: SGD mitochondrial crista junction Inferred from direct assay PubMed 22009199. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 234	234	Altered inheritance of mitochondria protein 37, mitochondrial		PRO_0000203438
Regions
	Transmembrane	101 – 120	20	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P50945 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 8DFD8FD42E71B8DB	FASTA	234	26,960
	10 20 30 40 50 60 MVNFYDDVDE SKSHGEFPLI PVVLQNSSEL SVRTIPTGNE IIESVHLTKW LRKYRNALAS 70 80 90 100 110 120 QLDRYEKGWQ SKIANFRLQV QHVINYSRKN IFNVDSENKH TVVPGSLIAL GAFFAGSIAV 130 140 150 160 170 180 NRSNWGAKRL IFGHKSSILE KLCTSLPSRI LLPWVLAAAT FKYWAPQTSQ NLVNATENDL 190 200 210 220 230 LPADFVKSYH NTWKRIYEEG YVAKKCDLKR QIDQTLQKNI RYAREQLYEK LEQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Quantitative trait loci mapped to single-nucleotide resolution in yeast." Deutschbauer A.M., Davis R.W. Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SK1.
[2]	"The sequence of a 21.3 kb DNA fragment from the left arm of yeast chromosome XIV reveals LEU4, MET4, POL1, RAS2, and six new open reading frames." Saiz J.E., Buitrago M.J., Soler A., del Rey F., Revuelta J.L. Yeast 12:403-409(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"A scalable method for integration and functional analysis of multiple microarray datasets." Huttenhower C., Hibbs M., Myers C., Troyanskaya O.G. Bioinformatics 22:2890-2897(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PREDICTION OF FUNCTION.
[9]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[10]	"Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis." Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A. PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[11]	"Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis." von der Malsburg K., Muller J.M., Bohnert M., Oeljeklaus S., Kwiatkowska P., Becker T., Loniewska-Lwowska A., Wiese S., Rao S., Milenkovic D., Hutu D.P., Zerbes R.M., Schulze-Specking A., Meyer H.E., Martinou J.C., Rospert S., Rehling P., Meisinger C. , Veenhuis M., Warscheid B., van der Klei I.J., Pfanner N., Chacinska A., van der Laan M. Dev. Cell 21:694-707(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, COMPOSITION OF THE MINOS/MITOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
[12]	"A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria." Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J. J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, COMPOSITION OF THE MINOS/MITOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ115393 Genomic DNA. Translation: AAZ22507.1. Z50161 Genomic DNA. Translation: CAA90526.1. Z71376 Genomic DNA. Translation: CAA95976.1. AY692704 Genomic DNA. Translation: AAT92723.1. BK006947 Genomic DNA. Translation: DAA10445.1.
PIR	S58252.
RefSeq	NP_014299.1. NM_001182938.1.
3D structure databases
ProteinModelPortal	P50945.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2042N.
IntAct	P50945. 3 interactions.
MINT	MINT-565064.
STRING	4932.YNL100W.
Proteomic databases
PaxDb	P50945.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YNL100W; YNL100W; YNL100W.
GeneID	855623.
KEGG	sce:YNL100W.
Organism-specific databases
CYGD	YNL100w.
SGD	S000005044. AIM37.
Phylogenomic databases
eggNOG	NOG40318.
OMA	NILTICA.
OrthoDB	EOG4MSH7V.
Enzyme and pathway databases
BioCyc	YEAST:G3O-33128-MONOMER.
Gene expression databases
Genevestigator	P50945.
GermOnline	YNL100W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	979819.

Entry information

Entry name

AIM37_YEAST

Accession

Primary (citable) accession number: P50945
Secondary accession number(s): D6W179, Q45U03

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program