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P50945 (AIM37_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Altered inheritance of mitochondria protein 37, mitochondrial
Gene names
Name:AIM37
Ordered Locus Names:YNL100W
ORF Names:N2190
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

As a component of the mitochondrial inner membrane organizing system (MINOS/MitOS) complex, important for normal mitochondrial morphology. Ref.8 Ref.11 Ref.12

Subunit structure

Component of the MINOS/MitOS complex, that includes FCJ1, AIM5, AIM13, AIM37, MOS1 and MOS2.

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein Ref.6 Ref.9 Ref.11 Ref.12.

Disruption phenotype

Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane. Ref.10 Ref.11 Ref.12

Sequence similarities

Belongs to the AIM37 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234Altered inheritance of mitochondria protein 37, mitochondrial
PRO_0000203438

Regions

Transmembrane101 – 12020Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P50945 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 8DFD8FD42E71B8DB

FASTA23426,960
        10         20         30         40         50         60 
MVNFYDDVDE SKSHGEFPLI PVVLQNSSEL SVRTIPTGNE IIESVHLTKW LRKYRNALAS 

        70         80         90        100        110        120 
QLDRYEKGWQ SKIANFRLQV QHVINYSRKN IFNVDSENKH TVVPGSLIAL GAFFAGSIAV 

       130        140        150        160        170        180 
NRSNWGAKRL IFGHKSSILE KLCTSLPSRI LLPWVLAAAT FKYWAPQTSQ NLVNATENDL 

       190        200        210        220        230 
LPADFVKSYH NTWKRIYEEG YVAKKCDLKR QIDQTLQKNI RYAREQLYEK LEQA 

« Hide

References

« Hide 'large scale' references
[1]"Quantitative trait loci mapped to single-nucleotide resolution in yeast."
Deutschbauer A.M., Davis R.W.
Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SK1.
[2]"The sequence of a 21.3 kb DNA fragment from the left arm of yeast chromosome XIV reveals LEU4, MET4, POL1, RAS2, and six new open reading frames."
Saiz J.E., Buitrago M.J., Soler A., del Rey F., Revuelta J.L.
Yeast 12:403-409(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A scalable method for integration and functional analysis of multiple microarray datasets."
Huttenhower C., Hibbs M., Myers C., Troyanskaya O.G.
Bioinformatics 22:2890-2897(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PREDICTION OF FUNCTION.
[9]"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[10]"Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[11]"Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis."
von der Malsburg K., Muller J.M., Bohnert M., Oeljeklaus S., Kwiatkowska P., Becker T., Loniewska-Lwowska A., Wiese S., Rao S., Milenkovic D., Hutu D.P., Zerbes R.M., Schulze-Specking A., Meyer H.E., Martinou J.C., Rospert S., Rehling P., Meisinger C. expand/collapse author list , Veenhuis M., Warscheid B., van der Klei I.J., Pfanner N., Chacinska A., van der Laan M.
Dev. Cell 21:694-707(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, COMPOSITION OF THE MINOS/MITOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
[12]"A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, COMPOSITION OF THE MINOS/MITOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ115393 Genomic DNA. Translation: AAZ22507.1.
Z50161 Genomic DNA. Translation: CAA90526.1.
Z71376 Genomic DNA. Translation: CAA95976.1.
AY692704 Genomic DNA. Translation: AAT92723.1.
BK006947 Genomic DNA. Translation: DAA10445.1.
PIRS58252.
RefSeqNP_014299.1. NM_001182938.1.

3D structure databases

ProteinModelPortalP50945.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35723. 20 interactions.
DIPDIP-2042N.
IntActP50945. 9 interactions.
MINTMINT-565064.
STRING4932.YNL100W.

Proteomic databases

PaxDbP50945.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL100W; YNL100W; YNL100W.
GeneID855623.
KEGGsce:YNL100W.

Organism-specific databases

CYGDYNL100w.
SGDS000005044. AIM37.

Phylogenomic databases

eggNOGNOG40318.
KOK17789.
OMANILTICA.
OrthoDBEOG7R83D8.

Enzyme and pathway databases

BioCycYEAST:G3O-33128-MONOMER.

Gene expression databases

GenevestigatorP50945.

Family and domain databases

ProtoNetSearch...

Other

NextBio979819.

Entry information

Entry nameAIM37_YEAST
AccessionPrimary (citable) accession number: P50945
Secondary accession number(s): D6W179, Q45U03
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families