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P50945

- MIC27_YEAST

UniProt

P50945 - MIC27_YEAST

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Protein

MICOS complex subunit MIC27

Gene

MIC27

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.2 Publications

GO - Biological processi

  1. cristae formation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33128-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC27
Alternative name(s):
Altered inheritance of mitochondria protein 37
Mitochondrial contact site complex 27 kDa subunit
Gene namesi
Name:MIC27
Synonyms:AIM37, MCS27
Ordered Locus Names:YNL100W
ORF Names:N2190
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL100w.
SGDiS000005044. MIC27.

Subcellular locationi

Mitochondrion inner membrane Curated; Multi-pass membrane protein Curated
Note: Enriched at crista junctions.5 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 100100Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei101 – 12020HelicalSequence AnalysisAdd
BLAST
Topological domaini121 – 14121Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei142 – 16120HelicalSequence AnalysisAdd
BLAST
Topological domaini162 – 23473Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. MICOS complex Source: SGD
  2. mitochondrial crista junction Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234MICOS complex subunit MIC27PRO_0000203438Add
BLAST

Proteomic databases

MaxQBiP50945.
PaxDbiP50945.

Expressioni

Gene expression databases

GenevestigatoriP50945.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.1 Publication

Protein-protein interaction databases

BioGridi35723. 20 interactions.
DIPiDIP-2042N.
IntActiP50945. 9 interactions.
MINTiMINT-565064.
STRINGi4932.YNL100W.

Structurei

3D structure databases

ProteinModelPortaliP50945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40318.
InParanoidiP50945.
KOiK17789.
OMAiNILTICA.
OrthoDBiEOG7R83D8.

Sequencei

Sequence statusi: Complete.

P50945-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNFYDDVDE SKSHGEFPLI PVVLQNSSEL SVRTIPTGNE IIESVHLTKW
60 70 80 90 100
LRKYRNALAS QLDRYEKGWQ SKIANFRLQV QHVINYSRKN IFNVDSENKH
110 120 130 140 150
TVVPGSLIAL GAFFAGSIAV NRSNWGAKRL IFGHKSSILE KLCTSLPSRI
160 170 180 190 200
LLPWVLAAAT FKYWAPQTSQ NLVNATENDL LPADFVKSYH NTWKRIYEEG
210 220 230
YVAKKCDLKR QIDQTLQKNI RYAREQLYEK LEQA
Length:234
Mass (Da):26,960
Last modified:October 1, 1996 - v1
Checksum:i8DFD8FD42E71B8DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115393 Genomic DNA. Translation: AAZ22507.1.
Z50161 Genomic DNA. Translation: CAA90526.1.
Z71376 Genomic DNA. Translation: CAA95976.1.
AY692704 Genomic DNA. Translation: AAT92723.1.
BK006947 Genomic DNA. Translation: DAA10445.1.
PIRiS58252.
RefSeqiNP_014299.1. NM_001182938.1.

Genome annotation databases

EnsemblFungiiYNL100W; YNL100W; YNL100W.
GeneIDi855623.
KEGGisce:YNL100W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115393 Genomic DNA. Translation: AAZ22507.1 .
Z50161 Genomic DNA. Translation: CAA90526.1 .
Z71376 Genomic DNA. Translation: CAA95976.1 .
AY692704 Genomic DNA. Translation: AAT92723.1 .
BK006947 Genomic DNA. Translation: DAA10445.1 .
PIRi S58252.
RefSeqi NP_014299.1. NM_001182938.1.

3D structure databases

ProteinModelPortali P50945.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35723. 20 interactions.
DIPi DIP-2042N.
IntActi P50945. 9 interactions.
MINTi MINT-565064.
STRINGi 4932.YNL100W.

Proteomic databases

MaxQBi P50945.
PaxDbi P50945.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL100W ; YNL100W ; YNL100W .
GeneIDi 855623.
KEGGi sce:YNL100W.

Organism-specific databases

CYGDi YNL100w.
SGDi S000005044. MIC27.

Phylogenomic databases

eggNOGi NOG40318.
InParanoidi P50945.
KOi K17789.
OMAi NILTICA.
OrthoDBi EOG7R83D8.

Enzyme and pathway databases

BioCyci YEAST:G3O-33128-MONOMER.

Miscellaneous databases

NextBioi 979819.

Gene expression databases

Genevestigatori P50945.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Quantitative trait loci mapped to single-nucleotide resolution in yeast."
    Deutschbauer A.M., Davis R.W.
    Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SK1.
  2. "The sequence of a 21.3 kb DNA fragment from the left arm of yeast chromosome XIV reveals LEU4, MET4, POL1, RAS2, and six new open reading frames."
    Saiz J.E., Buitrago M.J., Soler A., del Rey F., Revuelta J.L.
    Yeast 12:403-409(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A scalable method for integration and functional analysis of multiple microarray datasets."
    Huttenhower C., Hibbs M., Myers C., Troyanskaya O.G.
    Bioinformatics 22:2890-2897(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PREDICTION OF FUNCTION.
  9. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  10. "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
    Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
    PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  11. Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  12. "The mitochondrial contact site complex, a determinant of mitochondrial architecture."
    Harner M., Korner C., Walther D., Mokranjac D., Kaesmacher J., Welsch U., Griffith J., Mann M., Reggiori F., Neupert W.
    EMBO J. 30:4356-4370(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MICOS COMPLEX, MASS SPECTROMETRY, SUBCELLULAR LOCATION, TOPOLOGY.
  13. "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
    Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
    J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  14. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMIC27_YEAST
AccessioniPrimary (citable) accession number: P50945
Secondary accession number(s): D6W179, Q45U03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3