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Protein

Vacuolar amino acid transporter 4

Gene

AVT4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.1 Publication

GO - Molecular functioni

  • L-glutamine transmembrane transporter activity Source: SGD
  • L-isoleucine transmembrane transporter activity Source: SGD
  • L-tyrosine transmembrane transporter activity Source: SGD

GO - Biological processi

  • amino acid transmembrane export from vacuole Source: SGD

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33129-MONOMER
ReactomeiR-SCE-352230 Amino acid transport across the plasma membrane
R-SCE-428559 Proton-coupled neutral amino acid transporters
R-SCE-71240 Tryptophan catabolism

Protein family/group databases

TCDBi2.A.18.7.2 the amino acid/auxin permease (aaap) family

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar amino acid transporter 4
Gene namesi
Name:AVT4
Ordered Locus Names:YNL101W
ORF Names:N2185
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL101W
SGDiS000005045 AVT4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 242VacuolarSequence analysisAdd BLAST242
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 301CytoplasmicSequence analysisAdd BLAST38
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 326VacuolarSequence analysis4
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 373CytoplasmicSequence analysisAdd BLAST26
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 410VacuolarSequence analysisAdd BLAST16
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 438CytoplasmicSequence analysis7
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Topological domaini460 – 483VacuolarSequence analysisAdd BLAST24
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 515CytoplasmicSequence analysisAdd BLAST11
Transmembranei516 – 536HelicalSequence analysisAdd BLAST21
Topological domaini537 – 561VacuolarSequence analysisAdd BLAST25
Transmembranei562 – 582HelicalSequence analysisAdd BLAST21
Topological domaini583 – 621CytoplasmicSequence analysisAdd BLAST39
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 648VacuolarSequence analysis6
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Topological domaini670 – 692CytoplasmicSequence analysisAdd BLAST23
Transmembranei693 – 711HelicalSequence analysisAdd BLAST19
Topological domaini712 – 713VacuolarSequence analysis2

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938371 – 713Vacuolar amino acid transporter 4Add BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP50944
PRIDEiP50944

PTM databases

iPTMnetiP50944

Interactioni

Protein-protein interaction databases

BioGridi35722, 57 interactors
DIPiDIP-6754N
IntActiP50944, 2 interactors
MINTiP50944
STRINGi4932.YNL101W

Structurei

3D structure databases

ProteinModelPortaliP50944
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000011245
HOGENOMiHOG000185918
InParanoidiP50944
KOiK14209
OMAiMYPPMLH
OrthoDBiEOG092C13D8

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

Sequencei

Sequence statusi: Complete.

P50944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTNNGDGEH LGIRRNGNLR HPSNNMKIPR RAQSTVLNSN PFYSRKYSMS
60 70 80 90 100
TLTPRDICRS VDSRVFVDMS SPNFQTLEDP HRDEIINSVR LNYLNSSKRS
110 120 130 140 150
SVSHGNEAIP RVNPTKNSSA STIAAANVDS DDDETNLSSA GGDITHDIYK
160 170 180 190 200
LVKAEDPKRL RRPRSMENVT PKIEHHTKLS SASGLNVPGG FRREFIVNKK
210 220 230 240 250
RQEHQLNDSA SSDFTSHESD SINQSSPSSN QDIDKVPFLT RNFLEFLYVF
260 270 280 290 300
GHFAGESFED DFIPDSSNMM IRGEDERSAL LSRPDHMKVL PSAKGTTSTK
310 320 330 340 350
KVFLILLKSF IGTGVLFLPN AFHNGGLFFS VSMLAFFGIY SYWCYYILVQ
360 370 380 390 400
AKSSCGVSSF GDIGLKLYGP WMRIIILFSL VITQVGFSGA YMIFTAKNLQ
410 420 430 440 450
AFLDNVFHVG VLPLSYLMVF QTIIFIPLSF IRNISKLSLP SLLANFFIMA
460 470 480 490 500
GLVIVIIFTA KRLFFDLMGT PAMGVVYGLN ADRWTLFIGT AIFAFEGIGL
510 520 530 540 550
IIPVQDSMRN PEKFPLVLAL VILTATILFI SIATLGYLAY GSNVQTVILL
560 570 580 590 600
NLPQSNIFVN LIQLFYSIAI MLSTPLQLFP AIKIIENKFF PKFTKIYVKH
610 620 630 640 650
DDLTTRVELR PNSGKLNWKI KWLKNFIRSI IVIIVVSIAY FGSDNLDKFV
660 670 680 690 700
SVIGSLACIP LVYIYPSMLH LRGNSLPETK GEFWRFKPML DTILIFFGIA
710
SMLYTSYQSI FGV
Length:713
Mass (Da):80,026
Last modified:October 1, 1996 - v1
Checksum:iEAB458A2FEB660FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50161 Genomic DNA Translation: CAA90525.1
Z71377 Genomic DNA Translation: CAA95977.1
BK006947 Genomic DNA Translation: DAA10444.1
PIRiS58251
RefSeqiNP_014298.1, NM_001182939.1

Genome annotation databases

EnsemblFungiiYNL101W; YNL101W; YNL101W
GeneIDi855622
KEGGisce:YNL101W

Similar proteinsi

Entry informationi

Entry nameiAVT4_YEAST
AccessioniPrimary (citable) accession number: P50944
Secondary accession number(s): D6W178
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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