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P50941

- FABG_RICPR

UniProt

P50941 - FABG_RICPR

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Protein
3-oxoacyl-[acyl-carrier-protein] reductase FabG
Gene
fabG, RP762
Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381NADP By similarity
Binding sitei83 – 831NADP; via carbonyl oxygen By similarity
Binding sitei135 – 1351Substrate By similarity
Active sitei148 – 1481Proton acceptor By similarity
Binding sitei181 – 1811NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164NADP By similarity
Nucleotide bindingi57 – 582NADP By similarity
Nucleotide bindingi148 – 1525NADP By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB
  2. NAD binding Source: InterPro
  3. NADP binding Source: UniProtKB

GO - Biological processi

  1. fatty acid elongation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6427-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:RP762
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2412413-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054679Add
BLAST

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi272947.RP762.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 114
Turni12 – 154
Helixi17 – 2812
Beta strandi32 – 387
Helixi40 – 5011
Beta strandi52 – 587
Helixi64 – 729
Beta strandi78 – 825
Helixi100 – 1078
Helixi109 – 12517
Beta strandi128 – 1336
Helixi146 – 16621
Helixi167 – 1693
Beta strandi171 – 1788
Helixi191 – 20010
Helixi209 – 22012
Helixi222 – 2243
Beta strandi231 – 2355

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3F9IX-ray2.25A/B1-241[»]
ProteinModelPortaliP50941.

Miscellaneous databases

EvolutionaryTraceiP50941.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiTSELRES.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50941-1 [UniParc]FASTAAdd to Basket

« Hide

MIDLTGKTSL ITGASSGIGS AIARLLHKLG SKVIISGSNE EKLKSLGNAL    50
KDNYTIEVCN LANKEECSNL ISKTSNLDIL VCNAGITSDT LAIRMKDQDF 100
DKVIDINLKA NFILNREAIK KMIQKRYGRI INISSIVGIA GNPGQANYCA 150
SKAGLIGMTK SLSYEVATRG ITVNAVAPGF IKSDMTDKLN EKQREAIVQK 200
IPLGTYGIPE DVAYAVAFLA SNNASYITGQ TLHVNGGMLM V 241
Length:241
Mass (Da):25,759
Last modified:May 30, 2000 - v2
Checksum:iE43B8711545B8295
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235273 Genomic DNA. Translation: CAA15190.1.
U01959 Unassigned DNA. No translation available.
PIRiF71636.
RefSeqiNP_221114.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15190; CAA15190; CAA15190.
GeneIDi883564.
KEGGirpr:RP762.
PATRICi17902389. VBIRicPro72556_0798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235273 Genomic DNA. Translation: CAA15190.1 .
U01959 Unassigned DNA. No translation available.
PIRi F71636.
RefSeqi NP_221114.1. NC_000963.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3F9I X-ray 2.25 A/B 1-241 [» ]
ProteinModelPortali P50941.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA15190 ; CAA15190 ; CAA15190 .
GeneIDi 883564.
KEGGi rpr:RP762.
PATRICi 17902389. VBIRicPro72556_0798.

Phylogenomic databases

eggNOGi COG1028.
KOi K00059.
OMAi TSELRES.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci RETL1328306-WGS:GSTH-6427-MONOMER.

Miscellaneous databases

EvolutionaryTracei P50941.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.
  2. "Isolation and characterization of the Rickettsia prowazekii recA gene."
    Dunkin S.M., Winkler H.H., Wood D.O.
    J. Bacteriol. 176:1777-1781(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-41.
    Strain: Madrid E.
  3. "Codon usage and base composition in Rickettsia prowazekii."
    Andersson S.G.E., Sharp P.M.
    J. Mol. Evol. 42:525-536(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase Rickettsia prowazekii."
    Joint center for structural genomics (JCSG)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiFABG_RICPR
AccessioniPrimary (citable) accession number: P50941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: September 3, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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