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P50941

- FABG_RICPR

UniProt

P50941 - FABG_RICPR

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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381NADPBy similarity
Binding sitei83 – 831NADP; via carbonyl oxygenBy similarity
Binding sitei135 – 1351SubstrateBy similarity
Active sitei148 – 1481Proton acceptorPROSITE-ProRule annotation
Binding sitei181 – 1811NADP; via amide nitrogen and carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164NADPBy similarity
Nucleotide bindingi57 – 582NADPBy similarity
Nucleotide bindingi148 – 1525NADPBy similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB
  2. NAD binding Source: InterPro
  3. NADP binding Source: UniProtKB

GO - Biological processi

  1. fatty acid elongation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-6427-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:RP762
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000002480: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2412413-oxoacyl-[acyl-carrier-protein] reductase FabGPRO_0000054679Add
BLAST

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi272947.RP762.

Structurei

Secondary structure

1
241
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 114Combined sources
Turni12 – 154Combined sources
Helixi17 – 2812Combined sources
Beta strandi32 – 387Combined sources
Helixi40 – 5011Combined sources
Beta strandi52 – 587Combined sources
Helixi64 – 729Combined sources
Beta strandi78 – 825Combined sources
Helixi100 – 1078Combined sources
Helixi109 – 12517Combined sources
Beta strandi128 – 1336Combined sources
Helixi146 – 16621Combined sources
Helixi167 – 1693Combined sources
Beta strandi171 – 1788Combined sources
Helixi191 – 20010Combined sources
Helixi209 – 22012Combined sources
Helixi222 – 2243Combined sources
Beta strandi231 – 2355Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3F9IX-ray2.25A/B1-241[»]
ProteinModelPortaliP50941.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50941.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiTSELRES.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50941-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIDLTGKTSL ITGASSGIGS AIARLLHKLG SKVIISGSNE EKLKSLGNAL
60 70 80 90 100
KDNYTIEVCN LANKEECSNL ISKTSNLDIL VCNAGITSDT LAIRMKDQDF
110 120 130 140 150
DKVIDINLKA NFILNREAIK KMIQKRYGRI INISSIVGIA GNPGQANYCA
160 170 180 190 200
SKAGLIGMTK SLSYEVATRG ITVNAVAPGF IKSDMTDKLN EKQREAIVQK
210 220 230 240
IPLGTYGIPE DVAYAVAFLA SNNASYITGQ TLHVNGGMLM V
Length:241
Mass (Da):25,759
Last modified:May 30, 2000 - v2
Checksum:iE43B8711545B8295
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235273 Genomic DNA. Translation: CAA15190.1.
U01959 Unassigned DNA. No translation available.
PIRiF71636.
RefSeqiNP_221114.1. NC_000963.1.

Genome annotation databases

EnsemblBacteriaiCAA15190; CAA15190; CAA15190.
GeneIDi883564.
KEGGirpr:RP762.
PATRICi17902389. VBIRicPro72556_0798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ235273 Genomic DNA. Translation: CAA15190.1 .
U01959 Unassigned DNA. No translation available.
PIRi F71636.
RefSeqi NP_221114.1. NC_000963.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3F9I X-ray 2.25 A/B 1-241 [» ]
ProteinModelPortali P50941.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272947.RP762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAA15190 ; CAA15190 ; CAA15190 .
GeneIDi 883564.
KEGGi rpr:RP762.
PATRICi 17902389. VBIRicPro72556_0798.

Phylogenomic databases

eggNOGi COG1028.
KOi K00059.
OMAi TSELRES.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci RETL1328306-WGS:GSTH-6427-MONOMER.

Miscellaneous databases

EvolutionaryTracei P50941.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Madrid E.
  2. "Isolation and characterization of the Rickettsia prowazekii recA gene."
    Dunkin S.M., Winkler H.H., Wood D.O.
    J. Bacteriol. 176:1777-1781(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-41.
    Strain: Madrid E.
  3. "Codon usage and base composition in Rickettsia prowazekii."
    Andersson S.G.E., Sharp P.M.
    J. Mol. Evol. 42:525-536(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase Rickettsia prowazekii."
    Joint center for structural genomics (JCSG)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiFABG_RICPR
AccessioniPrimary (citable) accession number: P50941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3