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P50941

- FABG_RICPR

UniProt

P50941 - FABG_RICPR

Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

    Catalytic activityi

    (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381NADPBy similarity
    Binding sitei83 – 831NADP; via carbonyl oxygenBy similarity
    Binding sitei135 – 1351SubstrateBy similarity
    Active sitei148 – 1481Proton acceptorPROSITE-ProRule annotation
    Binding sitei181 – 1811NADP; via amide nitrogen and carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 164NADPBy similarity
    Nucleotide bindingi57 – 582NADPBy similarity
    Nucleotide bindingi148 – 1525NADPBy similarity

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB
    2. NAD binding Source: InterPro
    3. NADP binding Source: UniProtKB

    GO - Biological processi

    1. fatty acid elongation Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-6427-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
    Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase
    Beta-Ketoacyl-acyl carrier protein reductase
    Beta-ketoacyl-ACP reductase
    Gene namesi
    Name:fabG
    Ordered Locus Names:RP762
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2412413-oxoacyl-[acyl-carrier-protein] reductase FabGPRO_0000054679Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.1 Publication

    Protein-protein interaction databases

    STRINGi272947.RP762.

    Structurei

    Secondary structure

    1
    241
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi8 – 114
    Turni12 – 154
    Helixi17 – 2812
    Beta strandi32 – 387
    Helixi40 – 5011
    Beta strandi52 – 587
    Helixi64 – 729
    Beta strandi78 – 825
    Helixi100 – 1078
    Helixi109 – 12517
    Beta strandi128 – 1336
    Helixi146 – 16621
    Helixi167 – 1693
    Beta strandi171 – 1788
    Helixi191 – 20010
    Helixi209 – 22012
    Helixi222 – 2243
    Beta strandi231 – 2355

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3F9IX-ray2.25A/B1-241[»]
    ProteinModelPortaliP50941.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP50941.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1028.
    KOiK00059.
    OMAiTSELRES.
    OrthoDBiEOG6N3CR8.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR011284. 3oxo_ACP_reduc.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50941-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDLTGKTSL ITGASSGIGS AIARLLHKLG SKVIISGSNE EKLKSLGNAL    50
    KDNYTIEVCN LANKEECSNL ISKTSNLDIL VCNAGITSDT LAIRMKDQDF 100
    DKVIDINLKA NFILNREAIK KMIQKRYGRI INISSIVGIA GNPGQANYCA 150
    SKAGLIGMTK SLSYEVATRG ITVNAVAPGF IKSDMTDKLN EKQREAIVQK 200
    IPLGTYGIPE DVAYAVAFLA SNNASYITGQ TLHVNGGMLM V 241
    Length:241
    Mass (Da):25,759
    Last modified:May 30, 2000 - v2
    Checksum:iE43B8711545B8295
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235273 Genomic DNA. Translation: CAA15190.1.
    U01959 Unassigned DNA. No translation available.
    PIRiF71636.
    RefSeqiNP_221114.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15190; CAA15190; CAA15190.
    GeneIDi883564.
    KEGGirpr:RP762.
    PATRICi17902389. VBIRicPro72556_0798.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ235273 Genomic DNA. Translation: CAA15190.1 .
    U01959 Unassigned DNA. No translation available.
    PIRi F71636.
    RefSeqi NP_221114.1. NC_000963.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3F9I X-ray 2.25 A/B 1-241 [» ]
    ProteinModelPortali P50941.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP762.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15190 ; CAA15190 ; CAA15190 .
    GeneIDi 883564.
    KEGGi rpr:RP762.
    PATRICi 17902389. VBIRicPro72556_0798.

    Phylogenomic databases

    eggNOGi COG1028.
    KOi K00059.
    OMAi TSELRES.
    OrthoDBi EOG6N3CR8.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci RETL1328306-WGS:GSTH-6427-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P50941.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR011284. 3oxo_ACP_reduc.
    IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.
    2. "Isolation and characterization of the Rickettsia prowazekii recA gene."
      Dunkin S.M., Winkler H.H., Wood D.O.
      J. Bacteriol. 176:1777-1781(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-41.
      Strain: Madrid E.
    3. "Codon usage and base composition in Rickettsia prowazekii."
      Andersson S.G.E., Sharp P.M.
      J. Mol. Evol. 42:525-536(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. "Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase Rickettsia prowazekii."
      Joint center for structural genomics (JCSG)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS), SUBUNIT.

    Entry informationi

    Entry nameiFABG_RICPR
    AccessioniPrimary (citable) accession number: P50941
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3