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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38NADPBy similarity1
Binding sitei83NADP; via carbonyl oxygenBy similarity1
Binding sitei135SubstrateBy similarity1
Active sitei148Proton acceptorPROSITE-ProRule annotation1
Binding sitei181NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 16NADPBy similarity4
Nucleotide bindingi57 – 58NADPBy similarity2
Nucleotide bindingi148 – 152NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-767-MONOMER
BRENDAi1.1.1.100 5447
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:RP762
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546791 – 2413-oxoacyl-[acyl-carrier-protein] reductase FabGAdd BLAST241

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi272947.RP762

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 11Combined sources4
Turni12 – 15Combined sources4
Helixi17 – 28Combined sources12
Beta strandi32 – 38Combined sources7
Helixi40 – 50Combined sources11
Beta strandi52 – 58Combined sources7
Helixi64 – 72Combined sources9
Beta strandi78 – 82Combined sources5
Helixi100 – 107Combined sources8
Helixi109 – 125Combined sources17
Beta strandi128 – 133Combined sources6
Helixi146 – 166Combined sources21
Helixi167 – 169Combined sources3
Beta strandi171 – 178Combined sources8
Helixi191 – 200Combined sources10
Helixi209 – 220Combined sources12
Helixi222 – 224Combined sources3
Beta strandi231 – 235Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F9IX-ray2.25A/B1-241[»]
ProteinModelPortaliP50941
SMRiP50941
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50941

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHR Bacteria
ENOG410XNW1 LUCA
KOiK00059
OMAiGSRNIRC

Family and domain databases

InterProiView protein in InterPro
IPR011284 3oxo_ACP_reduc
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01830 3oxo_ACP_reduc, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P50941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDLTGKTSL ITGASSGIGS AIARLLHKLG SKVIISGSNE EKLKSLGNAL
60 70 80 90 100
KDNYTIEVCN LANKEECSNL ISKTSNLDIL VCNAGITSDT LAIRMKDQDF
110 120 130 140 150
DKVIDINLKA NFILNREAIK KMIQKRYGRI INISSIVGIA GNPGQANYCA
160 170 180 190 200
SKAGLIGMTK SLSYEVATRG ITVNAVAPGF IKSDMTDKLN EKQREAIVQK
210 220 230 240
IPLGTYGIPE DVAYAVAFLA SNNASYITGQ TLHVNGGMLM V
Length:241
Mass (Da):25,759
Last modified:May 30, 2000 - v2
Checksum:iE43B8711545B8295
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235273 Genomic DNA Translation: CAA15190.1
U01959 Unassigned DNA No translation available.
PIRiF71636
RefSeqiNP_221114.1, NC_000963.1
WP_010886363.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA15190; CAA15190; CAA15190
GeneIDi883564
KEGGirpr:RP762
PATRICifig|272947.5.peg.798

Similar proteinsi

Entry informationi

Entry nameiFABG_RICPR
AccessioniPrimary (citable) accession number: P50941
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health