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Protein

NADH-quinone oxidoreductase subunit L

Gene

nuoL

Organism
Rhodobacter capsulatus (Rhodopseudomonas capsulata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, Ubiquinone

Enzyme and pathway databases

BRENDAi1.6.99.5. 5381.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit L (EC:1.6.5.11)
Alternative name(s):
NADH dehydrogenase I subunit L
NDH-1 subunit L
Gene namesi
Name:nuoL
OrganismiRhodobacter capsulatus (Rhodopseudomonas capsulata)
Taxonomic identifieri1061 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Transmembranei588 – 608HelicalSequence analysisAdd BLAST21
Transmembranei655 – 675HelicalSequence analysisAdd BLAST21
Transmembranei686 – 706HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

No functional NADH-quinone oxidoreductase complex. Cells lacking this gene have a nearly normal respiratory growth phenotype on lactate, however they are unable to perform anaerobic photosynthesis. It is suggested that in R.capsulatus this complex may function in reverse flow under physiological conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001182211 – 712NADH-quinone oxidoreductase subunit LAdd BLAST712

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex (Probable).Curated

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D65. Bacteria.
COG1009. LUCA.
HOGENOMiHOG000100570.

Family and domain databases

InterProiView protein in InterPro
IPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
PfamiView protein in Pfam
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

P50939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTIILLAPL LGALIGGFGW RLITEKGALV VTTGLLFLSC ILSWVVFLTL
60 70 80 90 100
PAETQHIHLL DWIRSGALDT SWGIRLDRLT AIMLIVVTTV SALVHLYSWG
110 120 130 140 150
YMAHDENWTH HEAYKARFFA YLSFFTFAML MLVTSDNLVQ MFFGWEGVGV
160 170 180 190 200
ASYLLIGFYY KKPSANAAAI KAFVVNRVGD FGFALGIMGL FFLTDSIDMD
210 220 230 240 250
VIFASAPELA KTELHFLAWE FNAANLLAVL LFIGAMGKSA QLFLHTWLPD
260 270 280 290 300
AMEGPTPVSA LIHAATMVTA GVFLVCRMSP LFEYAPEAKM MVVYVGAVTA
310 320 330 340 350
FFAATVGLVQ NDIKRVIAYS TCSQLGYMFV AAGSGVYSVA MFHLLTHAFF
360 370 380 390 400
KAMLFLGAGS VIHAMHHEQD MRNYGGLRKK IPFTFAIMMI GTLAITGVGI
410 420 430 440 450
PFFSIGGVPV GFAGYLSKDA IIESAFASGN GFAFYVLVAA AGMTSFYSWR
460 470 480 490 500
LIFLTFYGEA RGDHHKHDHA HESPAVMLAP LALLAVGSVL AGMVWYHSFF
510 520 530 540 550
GDKVASFFNL PAAAHGEAHG TEHATEGHVP EAAMTAEAAH EAAMAGTMAM
560 570 580 590 600
AEPAAEHAVA KAPQGAIFMA ETNHVIHDAH GVPDWVKLSP FGAMVTGFFF
610 620 630 640 650
AWLYYIGDKP LPGRTARALP GLYRFLLNKW YFDELFDLLF VNPAKSLGRK
660 670 680 690 700
LWKGGDGAVI DGAINGLALG WIPFFTRVAG RIQSGYLFHY AFAMVLGIVA
710
LMFWVVRTGG MN
Length:712
Mass (Da):77,532
Last modified:May 30, 2000 - v2
Checksum:i3886161440079783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029365 Genomic DNA. Translation: AAC25003.1.

Genome annotation databases

GeneIDi31490415.

Similar proteinsi

Entry informationi

Entry nameiNUOL_RHOCA
AccessioniPrimary (citable) accession number: P50939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: July 5, 2017
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families