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P50924

- PYRF_LACLM

UniProt

P50924 - PYRF_LACLM

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, llmg_1107
Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei34 – 341Substrate By similarity
Active sitei63 – 631Proton donor By similarity
Binding sitei124 – 1241Substrate By similarity
Binding sitei186 – 1861Substrate By similarity
Binding sitei195 – 1951Substrate By similarity
Binding sitei215 – 2151Substrate; via amide nitrogen By similarity
Binding sitei216 – 2161Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciLLAC416870:GCDT-1133-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:llmg_1107
OrganismiLactococcus lactis subsp. cremoris (strain MG1363)
Taxonomic identifieri416870 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000000364: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_0000134550Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi416870.llmg_1107.

Structurei

3D structure databases

ProteinModelPortaliP50924.
SMRiP50924. Positions 1-237.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 7010Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiSAYHAIK.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50924-1 [UniParc]FASTAAdd to Basket

« Hide

MQENRPVIAL DFPEFSDVKD FLEKFDPSEK LYIKLGMELF YTAGPQVVYY    50
VKSLGHSVFL DLKLHDIPNT VESSMRVLAR LGVDMVNVHA AGGVEMMVAA 100
KRGLEAGTPI GRQRPKLIAV TQLTSTSEEI MQNDQKIMTS LEESVINYAQ 150
KTAQAGLDGV VCSAHEVEKI KAATSKEFIC LTPGIRPEGA SKGDQKRVMT 200
PKEARTIGSD YIVVGRPITQ AKDPVSAYHA IKEEWNQ 237
Length:237
Mass (Da):26,169
Last modified:October 1, 1996 - v1
Checksum:iF799EE4BCD7A1A54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74207 Genomic DNA. Translation: CAA52281.1.
AM406671 Genomic DNA. Translation: CAL97701.1.
RefSeqiYP_001032421.1. NC_009004.1.

Genome annotation databases

EnsemblBacteriaiCAL97701; CAL97701; llmg_1107.
GeneIDi4797639.
KEGGillm:llmg_1107.
PATRICi22283362. VBILacLac4574_1138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74207 Genomic DNA. Translation: CAA52281.1 .
AM406671 Genomic DNA. Translation: CAL97701.1 .
RefSeqi YP_001032421.1. NC_009004.1.

3D structure databases

ProteinModelPortali P50924.
SMRi P50924. Positions 1-237.
ModBasei Search...

Protein-protein interaction databases

STRINGi 416870.llmg_1107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL97701 ; CAL97701 ; llmg_1107 .
GeneIDi 4797639.
KEGGi llm:llmg_1107.
PATRICi 22283362. VBILacLac4574_1138.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi SAYHAIK.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci LLAC416870:GCDT-1133-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis and identification of the pyrKDbF operon from Lactococcus lactis including a novel gene, pyrK, involved in pyrimidine biosynthesis."
    Andersen P.S., Martinussen J., Hammer K.
    J. Bacteriol. 178:5005-5012(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
    Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
    J. Bacteriol. 189:3256-3270(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MG1363.

Entry informationi

Entry nameiPYRF_LACLM
AccessioniPrimary (citable) accession number: P50924
Secondary accession number(s): A2RK91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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