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Reviewed, UniProtKB/Swiss-Prot P50923 (ALF2_RHOCA)

Last modified June 16, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fructose-bisphosphate aldolase 2
      Short name=FBP aldolase
      Short name=FBPA
    EC=4.1.2.13
Alternative name(s):
    Fructose-bisphosphate aldolase II
    Fructose-1,6-bisphosphate aldolase
Gene names
Name: cbbA
Synonyms: cfxB
OrganismRhodobacter capsulatus (Rhodopseudomonas capsulata)
Taxonomic identifier1061 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length114 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactor

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.

Pathway

Carbohydrate biosynthesis; Calvin cycle.

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Subunit structure

Homodimer By similarity.

Miscellaneous

This protein is encoded within the form II ribulose-bisphosphate carboxylase operon.

Sequence similarities

Belongs to the class II fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processCalvin cycle
Glycolysis
   LigandZinc
   Molecular functionLyase
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

reductive pentose-phosphate cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 114›114Fructose-bisphosphate aldolase 2
PRO_0000178732

Regions

Region35 – 384Dihydroxyacetone phosphate binding By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P50923-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 18811FF5D217BD92

FASTA11412,747
        10         20         30         40         50         60 
LQDIINEFGG AMPQTFGVPV EEIVRGIKMG VRKVNIDTDC RMRMTGQFRR IAEQNKAEFD 

        70         80         90        100        110 
PRKFLKPAMD AMRDLCKARL EAFGTAGHAS KIKVIPMDDM AKRYASGSLA PKTN 

« Hide

References

[1]Larimer F.W., Lu T.-Y.S., Buley D.M.
Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 11166 / DSM 1710 / IFO 16435 / LMG 2962 / NCIB 8254.

Cross-references

Sequence databases

U23145 Genomic DNA. Translation: AAB82047.1.
PIRT10505.

3D structure databases

ModBaseSearch...

Enzyme and pathway databases

BRENDA4.1.2.13. 567.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
ProDomPD002376. K_bP_aldolase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00602. ALDOLASE_CLASS_II_1. Partial match.
PS00806. ALDOLASE_CLASS_II_2. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF2_RHOCA
AccessionPrimary (citable) accession number: P50923
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents