P50923 (ALF2_RHOCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-bisphosphate aldolase 2
Short name=FBP aldolase
Short name=FBPA
EC=4.1.2.13

Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Fructose-bisphosphate aldolase II

Gene names

Name:	cbbA
Synonyms:	cfxB

Organism

Rhodobacter capsulatus (Rhodopseudomonas capsulata)

Taxonomic identifier

1061 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	114 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.
Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Cofactor	Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.
Pathway	Carbohydrate biosynthesis; Calvin cycle. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Subunit structure	Homodimer By similarity.
Miscellaneous	This protein is encoded within the form II ribulose-bisphosphate carboxylase operon.
Sequence similarities	Belongs to the class II fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Calvin cycle Glycolysis
Ligand	Zinc
Molecular function	Lyase
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway reductive pentose-phosphate cycle Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 114	›114	Fructose-bisphosphate aldolase 2		PRO_0000178732
Regions
	Region	35 – 38	4	Dihydroxyacetone phosphate binding By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P50923 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 18811FF5D217BD92	FASTA	114	12,747
	10 20 30 40 50 60 LQDIINEFGG AMPQTFGVPV EEIVRGIKMG VRKVNIDTDC RMRMTGQFRR IAEQNKAEFD 70 80 90 100 110 PRKFLKPAMD AMRDLCKARL EAFGTAGHAS KIKVIPMDDM AKRYASGSLA PKTN

References

[1]	Larimer F.W., Lu T.-Y.S., Buley D.M. Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 11166 / DSM 1710 / JCM 21090 / LMG 2962 / NBRC 16435 / NCIMB 8254.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U23145 Genomic DNA. Translation: AAB82047.1.
PIR	T10505.
3D structure databases
ProteinModelPortal	P50923.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00109; UER00183. UPA00116.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR000771. Ketose_bisP_aldolase_II. [Graphical view]
Pfam	PF01116. F_bP_aldolase. 1 hit. [Graphical view]
PROSITE	PS00602. ALDOLASE_CLASS_II_1. Partial match. PS00806. ALDOLASE_CLASS_II_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALF2_RHOCA

Accession

Primary (citable) accession number: P50923

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	March 6, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program