Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L14

Gene

RPL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • ribosomal large subunit biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139239-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L14
Alternative name(s):
CAG-ISL 7
Gene namesi
Name:RPL14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:10305. RPL14.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9045.
OpenTargetsiENSG00000188846.
PharmGKBiPA34673.

Polymorphism and mutation databases

BioMutaiRPL14.
DMDMi212276521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001320312 – 21560S ribosomal protein L14Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79N6-acetyllysineCombined sources1
Modified residuei85N6-acetyllysine; alternateCombined sources1
Modified residuei85N6-succinyllysine; alternateBy similarity1
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei139PhosphoserineCombined sources1
Modified residuei204N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP50914.
MaxQBiP50914.
PaxDbiP50914.
PeptideAtlasiP50914.
PRIDEiP50914.
TopDownProteomicsiP50914.

2D gel databases

SWISS-2DPAGEP50914.

PTM databases

iPTMnetiP50914.
PhosphoSitePlusiP50914.
SwissPalmiP50914.

Expressioni

Gene expression databases

BgeeiENSG00000188846.
CleanExiHS_RPL14.
ExpressionAtlasiP50914. baseline and differential.
GenevisibleiP50914. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-356746,EBI-5323863
PHLDA1Q8WV242EBI-356746,EBI-738731

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi114507. 232 interactors.
IntActiP50914. 29 interactors.
MINTiMINT-1156434.
STRINGi9606.ENSP00000345156.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LM1-215[»]
4V6Xelectron microscopy5.00CM1-215[»]
5AJ0electron microscopy3.50AM1-215[»]
ProteinModelPortaliP50914.
SMRiP50914.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati171 – 1751-15
Repeati176 – 1801-25
Repeati181 – 1851-35
Repeati186 – 1901-45
Repeati193 – 1952-13
Repeati196 – 1982-23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni171 – 1904 X 5 AA tandem repeats of Q-K-A-[PAS]-XAdd BLAST20
Regioni193 – 1982 X 3 AA tandem repeats of K-[GA]-Q6

Sequence similaritiesi

Belongs to the ribosomal protein L14e family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3421. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000007888.
HOVERGENiHBG005187.
InParanoidiP50914.
KOiK02875.
OMAiHSARQKF.
OrthoDBiEOG091G0VTN.
PhylomeDBiP50914.
TreeFamiTF314356.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR014722. Rib_L2_dom2.
IPR002784. Ribosomal_L14e_dom.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01929. Ribosomal_L14e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50914-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFRRFVEVG RVAYVSFGPH AGKLVAIVDV IDQNRALVDG PCTQVRRQAM
60 70 80 90 100
PFKCMQLTDF ILKFPHSAHQ KYVRQAWQKA DINTKWAATR WAKKIEARER
110 120 130 140 150
KAKMTDFDRF KVMKAKKMRN RIIKNEVKKL QKAALLKASP KKAPGTKGTA
160 170 180 190 200
AAAAAAAAAK VPAKKITAAS KKAPAQKVPA QKATGQKAAP APKAQKGQKA
210
PAQKAPAPKA SGKKA
Length:215
Mass (Da):23,432
Last modified:November 4, 2008 - v4
Checksum:i4C63DE4FC8E687FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65P → L in BAA13443 (PubMed:9480843).Curated1

Polymorphismi

The poly-Ala stretch is highly polymorphic.4 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013633138A → S.1
Natural variantiVAR_047109158 – 159Missing .2 Publications2
Natural variantiVAR_013634159A → AA.1
Natural variantiVAR_014070159A → AAA.1
Natural variantiVAR_013635159A → AAAA.1
Natural variantiVAR_013636159A → AAAAA.1
Natural variantiVAR_006923159A → AAAAAA.3 Publications1
Natural variantiVAR_013637159A → AAAAAAAA.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16738 mRNA. Translation: AAC16021.1.
D87735 mRNA. Translation: BAA13443.1.
AB061822 Genomic DNA. Translation: BAB79460.1.
DQ118667 mRNA. Translation: AAZ38460.1.
AK223111 mRNA. Translation: BAD96831.1.
AC104186 Genomic DNA. No translation available.
BC000606 mRNA. Translation: AAH00606.1.
BC005134 mRNA. Translation: AAH05134.1.
BC009294 mRNA. Translation: AAH09294.1.
BC019651 mRNA. Translation: AAH19651.1.
BC022805 mRNA. Translation: AAH22805.1.
BC029036 mRNA. Translation: AAH29036.1.
AB046407 Genomic DNA. Translation: BAB21253.1.
CCDSiCCDS33739.1.
CCDS43070.1.
RefSeqiNP_001030168.1. NM_001034996.2.
NP_003964.3. NM_003973.4.
UniGeneiHs.446522.

Genome annotation databases

EnsembliENST00000338970; ENSP00000345156; ENSG00000188846.
ENST00000396203; ENSP00000379506; ENSG00000188846.
GeneIDi9045.
KEGGihsa:9045.
UCSCiuc003ckg.5. human.

Keywords - Coding sequence diversityi

Polymorphism, Triplet repeat expansion

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16738 mRNA. Translation: AAC16021.1.
D87735 mRNA. Translation: BAA13443.1.
AB061822 Genomic DNA. Translation: BAB79460.1.
DQ118667 mRNA. Translation: AAZ38460.1.
AK223111 mRNA. Translation: BAD96831.1.
AC104186 Genomic DNA. No translation available.
BC000606 mRNA. Translation: AAH00606.1.
BC005134 mRNA. Translation: AAH05134.1.
BC009294 mRNA. Translation: AAH09294.1.
BC019651 mRNA. Translation: AAH19651.1.
BC022805 mRNA. Translation: AAH22805.1.
BC029036 mRNA. Translation: AAH29036.1.
AB046407 Genomic DNA. Translation: BAB21253.1.
CCDSiCCDS33739.1.
CCDS43070.1.
RefSeqiNP_001030168.1. NM_001034996.2.
NP_003964.3. NM_003973.4.
UniGeneiHs.446522.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LM1-215[»]
4V6Xelectron microscopy5.00CM1-215[»]
5AJ0electron microscopy3.50AM1-215[»]
ProteinModelPortaliP50914.
SMRiP50914.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114507. 232 interactors.
IntActiP50914. 29 interactors.
MINTiMINT-1156434.
STRINGi9606.ENSP00000345156.

PTM databases

iPTMnetiP50914.
PhosphoSitePlusiP50914.
SwissPalmiP50914.

Polymorphism and mutation databases

BioMutaiRPL14.
DMDMi212276521.

2D gel databases

SWISS-2DPAGEP50914.

Proteomic databases

EPDiP50914.
MaxQBiP50914.
PaxDbiP50914.
PeptideAtlasiP50914.
PRIDEiP50914.
TopDownProteomicsiP50914.

Protocols and materials databases

DNASUi9045.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338970; ENSP00000345156; ENSG00000188846.
ENST00000396203; ENSP00000379506; ENSG00000188846.
GeneIDi9045.
KEGGihsa:9045.
UCSCiuc003ckg.5. human.

Organism-specific databases

CTDi9045.
DisGeNETi9045.
GeneCardsiRPL14.
H-InvDBHIX0003196.
HIX0036844.
HGNCiHGNC:10305. RPL14.
neXtProtiNX_P50914.
OpenTargetsiENSG00000188846.
PharmGKBiPA34673.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3421. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000007888.
HOVERGENiHBG005187.
InParanoidiP50914.
KOiK02875.
OMAiHSARQKF.
OrthoDBiEOG091G0VTN.
PhylomeDBiP50914.
TreeFamiTF314356.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139239-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL14. human.
GeneWikii60S_ribosomal_protein_L14.
GenomeRNAii9045.
PROiP50914.

Gene expression databases

BgeeiENSG00000188846.
CleanExiHS_RPL14.
ExpressionAtlasiP50914. baseline and differential.
GenevisibleiP50914. HS.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR014722. Rib_L2_dom2.
IPR002784. Ribosomal_L14e_dom.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01929. Ribosomal_L14e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL14_HUMAN
AccessioniPrimary (citable) accession number: P50914
Secondary accession number(s): Q45RF0
, Q53G20, Q8TBD5, Q8WUT0, Q92579, Q96GR0, Q9BSB8, Q9BW65, Q9BYF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: November 2, 2016
This is version 173 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.