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P50910 (XYLA_STRDI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xylose isomerase

EC=5.3.1.5
Gene names
Name:xylA
OrganismStreptomyces diastaticus
Taxonomic identifier1956 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in D-xylose catabolism. HAMAP-Rule MF_00455

Catalytic activity

D-xylopyranose = D-xylulose. HAMAP-Rule MF_00455

Cofactor

Binds 2 cobalt ions per subunit.

Subunit structure

Homotetramer.

Subcellular location

Cytoplasm HAMAP-Rule MF_00455.

Sequence similarities

Belongs to the xylose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandCobalt
Metal-binding
   Molecular functionIsomerase
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

xylose isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Xylose isomerase HAMAP-Rule MF_00455
PRO_0000195799

Sites

Active site541 By similarity
Active site571 By similarity
Metal binding1811Cobalt 1
Metal binding2171Cobalt 1
Metal binding2171Cobalt 2
Metal binding2201Cobalt 2
Metal binding2451Cobalt 1
Metal binding2551Cobalt 2
Metal binding2571Cobalt 2
Metal binding2871Cobalt 1

Secondary structure

................................................................. 388
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P50910 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: EFB9DA125AB1DEB0

FASTA38842,676
        10         20         30         40         50         60 
MSYQPTPEDK FTFGLWTVGW QGRDPFGDAT RGALDPAESV RRLAELGAHG VTFHDDDLIP 

        70         80         90        100        110        120 
FGATDSERAE HIKRFRQGLD ETGMKVPMAT TNLFTHPVFK DGGFTANDRD VRRYAVRKTI 

       130        140        150        160        170        180 
RNIDLAVELG AQTYVAWGGR EGAESGAAKD VRVALDRMKE AFDLLGEYVT SQGYDTPFAI 

       190        200        210        220        230        240 
EPKPNEPRGD ILLPTIGHAL AFIDGLERPE LYGVNPEVGH EQMAGLNFPH GIAQALWAGK 

       250        260        270        280        290        300 
LFHIDLNGQS GIKYDQDLRF GPGDLAAAFW LVDLLESAGY EGPRHFDFKP PRTEDFDGVW 

       310        320        330        340        350        360 
ASAAGCMRNY LILKERAAAF RADPEVQEAL RAARLDELAQ PTAGDGLQAL LPDRSAFEDF 

       370        380 
DPDAAAARGM AFERLDQLAM DHLLGARG 

« Hide

References

[1]"The sequence of xylose isomerase gene from Streptomyces diastaticus No. 7 M1033."
Wang Y., Huang Z., Dai X., Liu J., Cui T., Niu L., Wang C., Xu X.
Chin. J. Biotechnol. 10:97-103(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: No. 7 / M1033.
[2]"Structure of xylose isomerase from Streptomyces diastaticus no. 7 strain M1033 at 1.85 A resolution."
Zhu X., Teng M., Niu L., Xu C., Wang Y.
Acta Crystallogr. D 56:129-136(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
Strain: No. 7 / M1033.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S73809 Genomic DNA. Translation: AAB32873.1.
PIRJC1031.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1CLKX-ray1.90A2-388[»]
1QT1X-ray1.85A/B2-388[»]
ProteinModelPortalP50910.
SMRP50910. Positions 2-388.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00455. Xylose_isom_A.
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
SUPFAMSSF51658. SSF51658. 1 hit.
TIGRFAMsTIGR02631. xylA_Arthro. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP50910.

Entry information

Entry nameXYLA_STRDI
AccessionPrimary (citable) accession number: P50910
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references