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P50910

- XYLA_STRDI

UniProt

P50910 - XYLA_STRDI

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Protein

Xylose isomerase

Gene

xylA

Organism
Streptomyces diastaticus
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in D-xylose catabolism.

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Co2+Note: Binds 2 cobalt ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541By similarity
Active sitei57 – 571By similarity
Metal bindingi181 – 1811Cobalt 1
Metal bindingi217 – 2171Cobalt 1
Metal bindingi217 – 2171Cobalt 2
Metal bindingi220 – 2201Cobalt 2
Metal bindingi245 – 2451Cobalt 1
Metal bindingi255 – 2551Cobalt 2
Metal bindingi257 – 2571Cobalt 2
Metal bindingi287 – 2871Cobalt 1

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Cobalt, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiStreptomyces diastaticus
Taxonomic identifieri1956 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Xylose isomerasePRO_0000195799Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1
388
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 93Combined sources
Beta strandi11 – 144Combined sources
Helixi15 – 184Combined sources
Helixi36 – 4611Combined sources
Beta strandi50 – 545Combined sources
Helixi55 – 584Combined sources
Helixi65 – 8218Combined sources
Beta strandi85 – 906Combined sources
Beta strandi94 – 963Combined sources
Helixi97 – 993Combined sources
Helixi109 – 12921Combined sources
Beta strandi132 – 1365Combined sources
Beta strandi141 – 1488Combined sources
Helixi151 – 17222Combined sources
Beta strandi178 – 1803Combined sources
Beta strandi184 – 19310Combined sources
Helixi196 – 2038Combined sources
Beta strandi206 – 2083Combined sources
Helixi209 – 2113Combined sources
Beta strandi212 – 2143Combined sources
Helixi218 – 2225Combined sources
Turni223 – 2253Combined sources
Helixi228 – 23710Combined sources
Beta strandi251 – 2544Combined sources
Beta strandi260 – 2645Combined sources
Helixi265 – 27814Combined sources
Beta strandi284 – 2863Combined sources
Helixi296 – 32227Combined sources
Helixi324 – 3329Combined sources
Helixi335 – 3395Combined sources
Turni342 – 3454Combined sources
Helixi347 – 3504Combined sources
Helixi354 – 3563Combined sources
Turni357 – 3593Combined sources
Helixi362 – 3676Combined sources
Helixi372 – 38413Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CLKX-ray1.90A2-388[»]
1QT1X-ray1.85A/B2-388[»]
ProteinModelPortaliP50910.
SMRiP50910. Positions 2-388.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50910.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50910-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYQPTPEDK FTFGLWTVGW QGRDPFGDAT RGALDPAESV RRLAELGAHG
60 70 80 90 100
VTFHDDDLIP FGATDSERAE HIKRFRQGLD ETGMKVPMAT TNLFTHPVFK
110 120 130 140 150
DGGFTANDRD VRRYAVRKTI RNIDLAVELG AQTYVAWGGR EGAESGAAKD
160 170 180 190 200
VRVALDRMKE AFDLLGEYVT SQGYDTPFAI EPKPNEPRGD ILLPTIGHAL
210 220 230 240 250
AFIDGLERPE LYGVNPEVGH EQMAGLNFPH GIAQALWAGK LFHIDLNGQS
260 270 280 290 300
GIKYDQDLRF GPGDLAAAFW LVDLLESAGY EGPRHFDFKP PRTEDFDGVW
310 320 330 340 350
ASAAGCMRNY LILKERAAAF RADPEVQEAL RAARLDELAQ PTAGDGLQAL
360 370 380
LPDRSAFEDF DPDAAAARGM AFERLDQLAM DHLLGARG
Length:388
Mass (Da):42,676
Last modified:October 1, 1996 - v1
Checksum:iEFB9DA125AB1DEB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73809 Genomic DNA. Translation: AAB32873.1.
PIRiJC1031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73809 Genomic DNA. Translation: AAB32873.1 .
PIRi JC1031.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1CLK X-ray 1.90 A 2-388 [» ]
1QT1 X-ray 1.85 A/B 2-388 [» ]
ProteinModelPortali P50910.
SMRi P50910. Positions 2-388.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P50910.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02631. xylA_Arthro. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of xylose isomerase gene from Streptomyces diastaticus No. 7 M1033."
    Wang Y., Huang Z., Dai X., Liu J., Cui T., Niu L., Wang C., Xu X.
    Chin. J. Biotechnol. 10:97-103(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: No. 7 / M1033.
  2. "Structure of xylose isomerase from Streptomyces diastaticus no. 7 strain M1033 at 1.85 A resolution."
    Zhu X., Teng M., Niu L., Xu C., Wang Y.
    Acta Crystallogr. D 56:129-136(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
    Strain: No. 7 / M1033.

Entry informationi

Entry nameiXYLA_STRDI
AccessioniPrimary (citable) accession number: P50910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3