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P50910

- XYLA_STRDI

UniProt

P50910 - XYLA_STRDI

Protein

Xylose isomerase

Gene

xylA

Organism
Streptomyces diastaticus
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Involved in D-xylose catabolism.

    Catalytic activityi

    D-xylopyranose = D-xylulose.

    Cofactori

    Binds 2 cobalt ions per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei54 – 541By similarity
    Active sitei57 – 571By similarity
    Metal bindingi181 – 1811Cobalt 1
    Metal bindingi217 – 2171Cobalt 1
    Metal bindingi217 – 2171Cobalt 2
    Metal bindingi220 – 2201Cobalt 2
    Metal bindingi245 – 2451Cobalt 1
    Metal bindingi255 – 2551Cobalt 2
    Metal bindingi257 – 2571Cobalt 2
    Metal bindingi287 – 2871Cobalt 1

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shunt, Xylose metabolism

    Keywords - Ligandi

    Cobalt, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomerase (EC:5.3.1.5)
    Gene namesi
    Name:xylA
    OrganismiStreptomyces diastaticus
    Taxonomic identifieri1956 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Xylose isomerasePRO_0000195799Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.

    Structurei

    Secondary structure

    1
    388
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 93
    Beta strandi11 – 144
    Helixi15 – 184
    Helixi36 – 4611
    Beta strandi50 – 545
    Helixi55 – 584
    Helixi65 – 8218
    Beta strandi85 – 906
    Beta strandi94 – 963
    Helixi97 – 993
    Helixi109 – 12921
    Beta strandi132 – 1365
    Beta strandi141 – 1488
    Helixi151 – 17222
    Beta strandi178 – 1803
    Beta strandi184 – 19310
    Helixi196 – 2038
    Beta strandi206 – 2083
    Helixi209 – 2113
    Beta strandi212 – 2143
    Helixi218 – 2225
    Turni223 – 2253
    Helixi228 – 23710
    Beta strandi251 – 2544
    Beta strandi260 – 2645
    Helixi265 – 27814
    Beta strandi284 – 2863
    Helixi296 – 32227
    Helixi324 – 3329
    Helixi335 – 3395
    Turni342 – 3454
    Helixi347 – 3504
    Helixi354 – 3563
    Turni357 – 3593
    Helixi362 – 3676
    Helixi372 – 38413

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1CLKX-ray1.90A2-388[»]
    1QT1X-ray1.85A/B2-388[»]
    ProteinModelPortaliP50910.
    SMRiP50910. Positions 2-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP50910.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.Curated

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013453. XylA_actinobac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50910-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYQPTPEDK FTFGLWTVGW QGRDPFGDAT RGALDPAESV RRLAELGAHG    50
    VTFHDDDLIP FGATDSERAE HIKRFRQGLD ETGMKVPMAT TNLFTHPVFK 100
    DGGFTANDRD VRRYAVRKTI RNIDLAVELG AQTYVAWGGR EGAESGAAKD 150
    VRVALDRMKE AFDLLGEYVT SQGYDTPFAI EPKPNEPRGD ILLPTIGHAL 200
    AFIDGLERPE LYGVNPEVGH EQMAGLNFPH GIAQALWAGK LFHIDLNGQS 250
    GIKYDQDLRF GPGDLAAAFW LVDLLESAGY EGPRHFDFKP PRTEDFDGVW 300
    ASAAGCMRNY LILKERAAAF RADPEVQEAL RAARLDELAQ PTAGDGLQAL 350
    LPDRSAFEDF DPDAAAARGM AFERLDQLAM DHLLGARG 388
    Length:388
    Mass (Da):42,676
    Last modified:October 1, 1996 - v1
    Checksum:iEFB9DA125AB1DEB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S73809 Genomic DNA. Translation: AAB32873.1.
    PIRiJC1031.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S73809 Genomic DNA. Translation: AAB32873.1 .
    PIRi JC1031.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1CLK X-ray 1.90 A 2-388 [» ]
    1QT1 X-ray 1.85 A/B 2-388 [» ]
    ProteinModelPortali P50910.
    SMRi P50910. Positions 2-388.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P50910.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013453. XylA_actinobac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02631. xylA_Arthro. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of xylose isomerase gene from Streptomyces diastaticus No. 7 M1033."
      Wang Y., Huang Z., Dai X., Liu J., Cui T., Niu L., Wang C., Xu X.
      Chin. J. Biotechnol. 10:97-103(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: No. 7 / M1033.
    2. "Structure of xylose isomerase from Streptomyces diastaticus no. 7 strain M1033 at 1.85 A resolution."
      Zhu X., Teng M., Niu L., Xu C., Wang Y.
      Acta Crystallogr. D 56:129-136(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
      Strain: No. 7 / M1033.

    Entry informationi

    Entry nameiXYLA_STRDI
    AccessioniPrimary (citable) accession number: P50910
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3