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Protein

Xylose isomerase

Gene

xylA

Organism
Streptomyces diastaticus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in D-xylose catabolism.

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Co2+Note: Binds 2 cobalt ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54By similarity1
Active sitei57By similarity1
Metal bindingi181Cobalt 11
Metal bindingi217Cobalt 11
Metal bindingi217Cobalt 21
Metal bindingi220Cobalt 21
Metal bindingi245Cobalt 11
Metal bindingi255Cobalt 21
Metal bindingi257Cobalt 21
Metal bindingi287Cobalt 11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandCobalt, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiStreptomyces diastaticus
Taxonomic identifieri1956 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957991 – 388Xylose isomeraseAdd BLAST388

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Beta strandi11 – 14Combined sources4
Helixi15 – 18Combined sources4
Helixi36 – 46Combined sources11
Beta strandi50 – 54Combined sources5
Helixi55 – 58Combined sources4
Helixi65 – 82Combined sources18
Beta strandi85 – 90Combined sources6
Beta strandi94 – 96Combined sources3
Helixi97 – 99Combined sources3
Helixi109 – 129Combined sources21
Beta strandi132 – 136Combined sources5
Beta strandi141 – 148Combined sources8
Helixi151 – 172Combined sources22
Beta strandi178 – 180Combined sources3
Beta strandi184 – 193Combined sources10
Helixi196 – 203Combined sources8
Beta strandi206 – 208Combined sources3
Helixi209 – 211Combined sources3
Beta strandi212 – 214Combined sources3
Helixi218 – 222Combined sources5
Turni223 – 225Combined sources3
Helixi228 – 237Combined sources10
Beta strandi251 – 254Combined sources4
Beta strandi260 – 264Combined sources5
Helixi265 – 278Combined sources14
Beta strandi284 – 286Combined sources3
Helixi296 – 322Combined sources27
Helixi324 – 332Combined sources9
Helixi335 – 339Combined sources5
Turni342 – 345Combined sources4
Helixi347 – 350Combined sources4
Helixi354 – 356Combined sources3
Turni357 – 359Combined sources3
Helixi362 – 367Combined sources6
Helixi372 – 384Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CLKX-ray1.90A2-388[»]
1QT1X-ray1.85A/B2-388[»]
ProteinModelPortaliP50910
SMRiP50910
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50910

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Family and domain databases

HAMAPiMF_00455 Xylose_isom_A, 1 hit
InterProiView protein in InterPro
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
IPR013453 XylA_actinobac
IPR001998 Xylose_isomerase
PANTHERiPTHR32176:SF0 PTHR32176:SF0, 1 hit
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PRINTSiPR00688 XYLOSISMRASE
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR02631 xylA_Arthro, 1 hit
PROSITEiView protein in PROSITE
PS51415 XYLOSE_ISOMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

P50910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQPTPEDK FTFGLWTVGW QGRDPFGDAT RGALDPAESV RRLAELGAHG
60 70 80 90 100
VTFHDDDLIP FGATDSERAE HIKRFRQGLD ETGMKVPMAT TNLFTHPVFK
110 120 130 140 150
DGGFTANDRD VRRYAVRKTI RNIDLAVELG AQTYVAWGGR EGAESGAAKD
160 170 180 190 200
VRVALDRMKE AFDLLGEYVT SQGYDTPFAI EPKPNEPRGD ILLPTIGHAL
210 220 230 240 250
AFIDGLERPE LYGVNPEVGH EQMAGLNFPH GIAQALWAGK LFHIDLNGQS
260 270 280 290 300
GIKYDQDLRF GPGDLAAAFW LVDLLESAGY EGPRHFDFKP PRTEDFDGVW
310 320 330 340 350
ASAAGCMRNY LILKERAAAF RADPEVQEAL RAARLDELAQ PTAGDGLQAL
360 370 380
LPDRSAFEDF DPDAAAARGM AFERLDQLAM DHLLGARG
Length:388
Mass (Da):42,676
Last modified:October 1, 1996 - v1
Checksum:iEFB9DA125AB1DEB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73809 Genomic DNA Translation: AAB32873.1
PIRiJC1031

Similar proteinsi

Entry informationi

Entry nameiXYLA_STRDI
AccessioniPrimary (citable) accession number: P50910
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

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