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P50910

- XYLA_STRDI

UniProt

P50910 - XYLA_STRDI

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Protein

Xylose isomerase

Gene
xylA
Organism
Streptomyces diastaticus
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in D-xylose catabolism.UniRule annotation

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Binds 2 cobalt ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541 By similarity
Active sitei57 – 571 By similarity
Metal bindingi181 – 1811Cobalt 1
Metal bindingi217 – 2171Cobalt 1
Metal bindingi217 – 2171Cobalt 2
Metal bindingi220 – 2201Cobalt 2
Metal bindingi245 – 2451Cobalt 1
Metal bindingi255 – 2551Cobalt 2
Metal bindingi257 – 2571Cobalt 2
Metal bindingi287 – 2871Cobalt 1

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Cobalt, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiStreptomyces diastaticus
Taxonomic identifieri1956 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Xylose isomeraseUniRule annotationPRO_0000195799Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1
388
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 93
Beta strandi11 – 144
Helixi15 – 184
Helixi36 – 4611
Beta strandi50 – 545
Helixi55 – 584
Helixi65 – 8218
Beta strandi85 – 906
Beta strandi94 – 963
Helixi97 – 993
Helixi109 – 12921
Beta strandi132 – 1365
Beta strandi141 – 1488
Helixi151 – 17222
Beta strandi178 – 1803
Beta strandi184 – 19310
Helixi196 – 2038
Beta strandi206 – 2083
Helixi209 – 2113
Beta strandi212 – 2143
Helixi218 – 2225
Turni223 – 2253
Helixi228 – 23710
Beta strandi251 – 2544
Beta strandi260 – 2645
Helixi265 – 27814
Beta strandi284 – 2863
Helixi296 – 32227
Helixi324 – 3329
Helixi335 – 3395
Turni342 – 3454
Helixi347 – 3504
Helixi354 – 3563
Turni357 – 3593
Helixi362 – 3676
Helixi372 – 38413

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CLKX-ray1.90A2-388[»]
1QT1X-ray1.85A/B2-388[»]
ProteinModelPortaliP50910.
SMRiP50910. Positions 2-388.

Miscellaneous databases

EvolutionaryTraceiP50910.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50910-1 [UniParc]FASTAAdd to Basket

« Hide

MSYQPTPEDK FTFGLWTVGW QGRDPFGDAT RGALDPAESV RRLAELGAHG    50
VTFHDDDLIP FGATDSERAE HIKRFRQGLD ETGMKVPMAT TNLFTHPVFK 100
DGGFTANDRD VRRYAVRKTI RNIDLAVELG AQTYVAWGGR EGAESGAAKD 150
VRVALDRMKE AFDLLGEYVT SQGYDTPFAI EPKPNEPRGD ILLPTIGHAL 200
AFIDGLERPE LYGVNPEVGH EQMAGLNFPH GIAQALWAGK LFHIDLNGQS 250
GIKYDQDLRF GPGDLAAAFW LVDLLESAGY EGPRHFDFKP PRTEDFDGVW 300
ASAAGCMRNY LILKERAAAF RADPEVQEAL RAARLDELAQ PTAGDGLQAL 350
LPDRSAFEDF DPDAAAARGM AFERLDQLAM DHLLGARG 388
Length:388
Mass (Da):42,676
Last modified:October 1, 1996 - v1
Checksum:iEFB9DA125AB1DEB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S73809 Genomic DNA. Translation: AAB32873.1.
PIRiJC1031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S73809 Genomic DNA. Translation: AAB32873.1 .
PIRi JC1031.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1CLK X-ray 1.90 A 2-388 [» ]
1QT1 X-ray 1.85 A/B 2-388 [» ]
ProteinModelPortali P50910.
SMRi P50910. Positions 2-388.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P50910.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02631. xylA_Arthro. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of xylose isomerase gene from Streptomyces diastaticus No. 7 M1033."
    Wang Y., Huang Z., Dai X., Liu J., Cui T., Niu L., Wang C., Xu X.
    Chin. J. Biotechnol. 10:97-103(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: No. 7 / M1033.
  2. "Structure of xylose isomerase from Streptomyces diastaticus no. 7 strain M1033 at 1.85 A resolution."
    Zhu X., Teng M., Niu L., Xu C., Wang Y.
    Acta Crystallogr. D 56:129-136(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
    Strain: No. 7 / M1033.

Entry informationi

Entry nameiXYLA_STRDI
AccessioniPrimary (citable) accession number: P50910
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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