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Protein

Ras GTPase-activating protein 1

Gene

Rasa1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21 (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: RGD
  • kinase binding Source: RGD
  • platelet-derived growth factor receptor binding Source: RGD
  • protein-containing complex binding Source: RGD

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • activation of GTPase activity Source: RGD
  • cell adhesion Source: UniProtKB
  • cellular response to epidermal growth factor stimulus Source: RGD
  • cellular response to fibroblast growth factor stimulus Source: RGD
  • cellular response to platelet-derived growth factor stimulus Source: RGD
  • male genitalia development Source: RGD
  • mitotic cytokinesis Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cell adhesion Source: UniProtKB
  • negative regulation of cell-matrix adhesion Source: UniProtKB
  • negative regulation of neuron apoptotic process Source: UniProtKB
  • negative regulation of Ras protein signal transduction Source: GO_Central
  • positive regulation of fibroblast proliferation Source: RGD
  • positive regulation of glucose import Source: RGD
  • positive regulation of GTPase activity Source: RGD
  • positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • regulation of actin filament polymerization Source: UniProtKB
  • response to drug Source: RGD
  • response to insulin Source: RGD
  • signal transduction Source: UniProtKB
  • vasculogenesis Source: UniProtKB

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein 1
Short name:
GAP
Short name:
GTPase-activating protein
Short name:
RasGAP
Alternative name(s):
Ras p21 protein activator
p120GAP
Gene namesi
Name:Rasa1
Synonyms:Rasa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3537 Rasa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566371 – 1038Ras GTPase-activating protein 1Add BLAST1038

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei606PhosphotyrosineBy similarity1
Modified residuei822PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity, whereas phosphorylation by LCK does not display any effect on stimulation activity (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP50904
PRIDEiP50904

PTM databases

iPTMnetiP50904
PhosphoSitePlusiP50904

Interactioni

Subunit structurei

Interacts with SQSTM1. Interacts with SPSB1. Interaction with SPSB1 does not promote degradation. Interacts with CAV2 (tyrosine phosphorylated form). Directly interacts with NCK1. Interacts with PDGFRB (tyrosine phosphorylated) (By similarity). Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1 (By similarity).By similarity

GO - Molecular functioni

  • kinase binding Source: RGD
  • platelet-derived growth factor receptor binding Source: RGD

Protein-protein interaction databases

BioGridi247705, 2 interactors
CORUMiP50904
IntActiP50904, 3 interactors
MINTiP50904
STRINGi10116.ENSRNOP00000047300

Structurei

3D structure databases

ProteinModelPortaliP50904
SMRiP50904
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 263SH2 1PROSITE-ProRule annotationAdd BLAST92
Domaini270 – 332SH3PROSITE-ProRule annotationAdd BLAST63
Domaini342 – 432SH2 2PROSITE-ProRule annotationAdd BLAST91
Domaini465 – 568PHPROSITE-ProRule annotationAdd BLAST104
Domaini572 – 667C2PROSITE-ProRule annotationAdd BLAST96
Domaini739 – 933Ras-GAPPROSITE-ProRule annotationAdd BLAST195

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi94 – 99Poly-Ala6
Compositional biasi126 – 132Poly-Pro7
Compositional biasi154 – 159Poly-Glu6

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG3508 Eukaryota
ENOG410XPU1 LUCA
HOGENOMiHOG000007794
HOVERGENiHBG057470
InParanoidiP50904
KOiK04352
PhylomeDBiP50904

Family and domain databases

CDDicd10354 SH2_Cterm_RasGAP, 1 hit
cd10353 SH2_Nterm_RasGAP, 1 hit
cd11788 SH3_RasGAP, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028554 p120-RasGAP
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR035842 RasGAP_C_SH2
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR035841 RasGAP_N_SH2
IPR035652 RasGAP_SH3
IPR008936 Rho_GTPase_activation_prot
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10194:SF19 PTHR10194:SF19, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00169 PH, 1 hit
PF00616 RasGAP, 1 hit
PF00017 SH2, 2 hits
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SM00252 SH2, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS50001 SH2, 2 hits
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

P50904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAAEAGSEE GGPATAGTGG AAATGSSAYP AACRVKLPAA PPMAVAPCPG
60 70 80 90 100
LADTDLAAAL GGGAASGSGF LGTGPVSGVL GGAALTGGAA AGVAGAAAAG
110 120 130 140 150
PAGDIALTKG TLSLPAETLG PGGGFPPLPP PPLLPPLGSG LGTVDEGDSL
160 170 180 190 200
DGPEYEEEEV AIPLTAPPTN QWYHGKLDRT IAEERLRQAG KSGSYLIRES
210 220 230 240 250
DRRPGSFVLS FLSQTNVVNH FRIIAMCGDY YIGGRRFSSL SDLIGYYSHV
260 270 280 290 300
SCLLKGEKLL YPVAPPEPVE DRRRVRAILP YTKVPDTDEI SFLKGDMFIV
310 320 330 340 350
HNELEDGWMW VTNLRTDEQG LIVEDLVEEV GREEDPHEGK IWFHGKISKQ
360 370 380 390 400
EAYNLLMTVG QVCSFLVRPS DNTPGDYSLY FRTNENIQRF KICPTPNNQF
410 420 430 440 450
MMGGRYYNSI GDIIDHYRKE QIVEGYYLKE PVPMQDQGQV LNDTVDGKEI
460 470 480 490 500
YNTIRRKTKD AFYKNIVKKG YLLKKGKGKR WKNLYFILEG SDAQLIYFES
510 520 530 540 550
EKRATKPKGL IDLSVCSVYV VHDSLFGRPN CFQIVVQHFS EEHYIFYFAG
560 570 580 590 600
ETPEQAEDWM KGLQAFCSLR KSSPGTSNKR LRQVSSLVLH IEEAHKLPVK
610 620 630 640 650
HFTNPYCNIY LNSVQVAKTH AREGQNPVWS EEFVFDDLPP DINRFEITLS
660 670 680 690 700
NKTKKSKDPD ILFMRCQLSR LQKGHATDEW FLLSSHIPLK GIEPGSLRVR
710 720 730 740 750
ARYSMEKIMP EEEYSEFKEL ILQKELHVVY ALSHVCGQDR TLLASILLKI
760 770 780 790 800
FLHEKLESLL LCTLNDREIS MEDEATTLFR ATTLASTLME QYMKATATQF
810 820 830 840 850
VHHALKDSIL KIMESKQSCE LSPSKLEKNE DVNTNLAHLL SILSELVEKI
860 870 880 890 900
FMASEILPPT LRYIYGCLQK SVQHKWPTNN TMRTRVVSGF VFLRLICPAI
910 920 930 940 950
LNPRMFNIIS DSPSPIAART LTLVAKSVQN LANLVEFGAK EPYMEGVNPF
960 970 980 990 1000
IKSNKHRMIM FLDELGNVPE LPDTTEHSRT DLSRDLAALH EICVAHSDEL
1010 1020 1030
RTLSNERGVQ QHVLKKLLAI TELLQQKQNQ YTKTNDVR
Length:1,038
Mass (Da):115,440
Last modified:October 1, 1996 - v1
Checksum:i242EE47131C1811E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13151 Unassigned DNA Translation: AAA16319.1
PIRiJT0663
RefSeqiNP_037267.1, NM_013135.1
UniGeneiRn.228988

Genome annotation databases

GeneIDi25676
KEGGirno:25676
UCSCiRGD:3537 rat

Similar proteinsi

Entry informationi

Entry nameiRASA1_RAT
AccessioniPrimary (citable) accession number: P50904
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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