ID   HOX3_BRAFL              Reviewed;         411 AA.
AC   P50901;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   24-JAN-2024, entry version 107.
DE   RecName: Full=Homeobox protein HOX3;
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1363226; DOI=10.1242/dev.116.3.653;
RA   Holland P.W., Holland L.Z., Williams N.A., Holland N.D.;
RT   "An amphioxus homeobox gene: sequence conservation, spatial expression
RT   during development and insights into vertebrate evolution.";
RL   Development 116:653-661(1992).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Localized expression of in the posterior mesoderm
CC       (but not in the somites), and region-specific expression in the dorsal
CC       nerve cord, of amphioxus neurulae, later embryos and larvae. The
CC       anterior limit to expression in the nerve cord is at the level of the
CC       four/five somite boundary at the neurula stage, and stabilizes to just
CC       anterior to the first nerve cord pigment spot to form.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X68045; CAA48180.1; -; Genomic_DNA.
DR   PIR; A49127; A49127.
DR   AlphaFoldDB; P50901; -.
DR   SMR; P50901; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   Proteomes; UP000001554; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45664:SF18; HOMEOBOX DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..411
FT                   /note="Homeobox protein HOX3"
FT                   /id="PRO_0000200274"
FT   DNA_BIND        135..194
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          51..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          104..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           98..103
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        52..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..231
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..263
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..317
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  44005 MW;  84740EDF2FB574A1 CRC64;
     MQKSPYYETT SQQLYNGYSY SNGERFGYEG SGGGGGGGSY GAEVTQDFGP SCSVRKPGST
     TGGGTGNVSP TCMKTNPADN NHGSAPQSNA SILANTKIYP WMKESRQNSK QRQQPNLSVG
     TTEPGESPGL GGAAGKRART AYTSAQLVEL EKEFHFNRYL CRPRRVEMAA MLNLTERQIK
     IWFQNRRMKY KKEQKVKGGG SGGGSGGMNS PSPPATTTPP GINPGPLPHP TTQPSLSQSN
     NMSNHMSMMG SLQQTQPAYS QYPPPHLNHS LPHQAPPHSV GLTMSGPVSP QCYQSNHSPC
     PPSSAPHPVP MGNHVPHPRQ GPPHMTNGLP ASPLEVVSQR QYTPPAPGPS PTGPGPGHHG
     LTNSYPECPP HHTELPHHQY STPMSVVNMN YCVNVQTQGN RLNSAPKLTH L
//