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P50901

- HOX3_BRAFL

UniProt

P50901 - HOX3_BRAFL

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Protein
Homeobox protein HOX3
Gene
N/A
Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi135 – 19460Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein HOX3
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Homeobox protein HOX3
PRO_0000200274Add
BLAST

Expressioni

Developmental stagei

Localized expression of in the posterior mesoderm (but not in the somites), and region-specific expression in the dorsal nerve cord, of amphioxus neurulae, later embryos and larvae. The anterior limit to expression in the nerve cord is at the level of the four/five somite boundary at the neurula stage, and stabilizes to just anterior to the first nerve cord pigment spot to form.

Structurei

3D structure databases

ProteinModelPortaliP50901.
SMRiP50901. Positions 136-194.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi98 – 1036Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 389Poly-Gly

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
HOVERGENiHBG107984.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50901-1 [UniParc]FASTAAdd to Basket

« Hide

MQKSPYYETT SQQLYNGYSY SNGERFGYEG SGGGGGGGSY GAEVTQDFGP    50
SCSVRKPGST TGGGTGNVSP TCMKTNPADN NHGSAPQSNA SILANTKIYP 100
WMKESRQNSK QRQQPNLSVG TTEPGESPGL GGAAGKRART AYTSAQLVEL 150
EKEFHFNRYL CRPRRVEMAA MLNLTERQIK IWFQNRRMKY KKEQKVKGGG 200
SGGGSGGMNS PSPPATTTPP GINPGPLPHP TTQPSLSQSN NMSNHMSMMG 250
SLQQTQPAYS QYPPPHLNHS LPHQAPPHSV GLTMSGPVSP QCYQSNHSPC 300
PPSSAPHPVP MGNHVPHPRQ GPPHMTNGLP ASPLEVVSQR QYTPPAPGPS 350
PTGPGPGHHG LTNSYPECPP HHTELPHHQY STPMSVVNMN YCVNVQTQGN 400
RLNSAPKLTH L 411
Length:411
Mass (Da):44,005
Last modified:October 1, 1996 - v1
Checksum:i84740EDF2FB574A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68045 Genomic DNA. Translation: CAA48180.1.
PIRiA49127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68045 Genomic DNA. Translation: CAA48180.1 .
PIRi A49127.

3D structure databases

ProteinModelPortali P50901.
SMRi P50901. Positions 136-194.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG284589.
HOVERGENi HBG107984.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An amphioxus homeobox gene: sequence conservation, spatial expression during development and insights into vertebrate evolution."
    Holland P.W., Holland L.Z., Williams N.A., Holland N.D.
    Development 116:653-661(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHOX3_BRAFL
AccessioniPrimary (citable) accession number: P50901
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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