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P50901 (HOX3_BRAFL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein HOX3
OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus)
Taxonomic identifier7739 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus.

Developmental stage

Localized expression of in the posterior mesoderm (but not in the somites), and region-specific expression in the dorsal nerve cord, of amphioxus neurulae, later embryos and larvae. The anterior limit to expression in the nerve cord is at the level of the four/five somite boundary at the neurula stage, and stabilizes to just anterior to the first nerve cord pigment spot to form.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411Homeobox protein HOX3
PRO_0000200274

Regions

DNA binding135 – 19460Homeobox
Motif98 – 1036Antp-type hexapeptide
Compositional bias30 – 389Poly-Gly

Sequences

Sequence LengthMass (Da)Tools
P50901 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 84740EDF2FB574A1

FASTA41144,005
        10         20         30         40         50         60 
MQKSPYYETT SQQLYNGYSY SNGERFGYEG SGGGGGGGSY GAEVTQDFGP SCSVRKPGST 

        70         80         90        100        110        120 
TGGGTGNVSP TCMKTNPADN NHGSAPQSNA SILANTKIYP WMKESRQNSK QRQQPNLSVG 

       130        140        150        160        170        180 
TTEPGESPGL GGAAGKRART AYTSAQLVEL EKEFHFNRYL CRPRRVEMAA MLNLTERQIK 

       190        200        210        220        230        240 
IWFQNRRMKY KKEQKVKGGG SGGGSGGMNS PSPPATTTPP GINPGPLPHP TTQPSLSQSN 

       250        260        270        280        290        300 
NMSNHMSMMG SLQQTQPAYS QYPPPHLNHS LPHQAPPHSV GLTMSGPVSP QCYQSNHSPC 

       310        320        330        340        350        360 
PPSSAPHPVP MGNHVPHPRQ GPPHMTNGLP ASPLEVVSQR QYTPPAPGPS PTGPGPGHHG 

       370        380        390        400        410 
LTNSYPECPP HHTELPHHQY STPMSVVNMN YCVNVQTQGN RLNSAPKLTH L 

« Hide

References

[1]"An amphioxus homeobox gene: sequence conservation, spatial expression during development and insights into vertebrate evolution."
Holland P.W., Holland L.Z., Williams N.A., Holland N.D.
Development 116:653-661(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68045 Genomic DNA. Translation: CAA48180.1.
PIRA49127.

3D structure databases

ProteinModelPortalP50901.
SMRP50901. Positions 136-194.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG284589.
HOVERGENHBG107984.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHOX3_BRAFL
AccessionPrimary (citable) accession number: P50901
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries