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Protein

Exoglucanase-2

Gene

celY

Organism
Clostridium stercorarium subsp. stercorarium (strain ATCC 35414 / DSM 8532 / NCIMB 11754)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiCBM3 Carbohydrate-Binding Module Family 3
GH48 Glycoside Hydrolase Family 48

Names & Taxonomyi

Protein namesi
Recommended name:
Exoglucanase-2 (EC:3.2.1.91)
Alternative name(s):
1,4-beta-cellobiohydrolase II
Avicelase II
Exocellobiohydrolase II
Exoglucanase II
Gene namesi
Name:celY
Ordered Locus Names:Cst_c18970
OrganismiClostridium stercorarium subsp. stercorarium (strain ATCC 35414 / DSM 8532 / NCIMB 11754)
Taxonomic identifieri1121335 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000011220 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000000803034 – 914Exoglucanase-2Add BLAST881

Proteomic databases

PRIDEiP50900

Structurei

3D structure databases

SMRiP50900
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini763 – 914CBM3PROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiPOG091H0EGP

Family and domain databases

Gene3Di1.50.10.10, 5 hits
2.170.160.10, 3 hits
2.60.40.10, 1 hit
2.60.40.710, 1 hit
4.10.870.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR005102 Carbo-bd_X2
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR001956 CBM3
IPR036966 CBM3_sf
IPR023309 Endo-1-4-beta-glucanase_dom2
IPR027390 Endoglucanase_F_dom3
IPR000556 Glyco_hydro_48F
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF00942 CBM_3, 1 hit
PF03442 CBM_X2, 1 hit
PF02011 Glyco_hydro_48, 1 hit
PRINTSiPR00844 GLHYDRLASE48
SMARTiView protein in SMART
SM01067 CBM_3, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF49384 SSF49384, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS51172 CBM3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRRLMKGIS LLTLVFLIGI MLQLSLKSEL TAYASSDDPY KQRFLELWEE
60 70 80 90 100
LHDPSNGYFS SHGIPYHAVE TLIVEAPDYG HLTTSEAMSY YLWLEALYGK
110 120 130 140 150
FTGDFSYFMK AWETIEKYMI PTEQDQPNRS MAGYNPAKPA TYAPEWEEPS
160 170 180 190 200
MYPSQLDFSA PVGIDPIYNE LVSTYGTNTI YGMHWLLDVD NWYGFGRRAD
210 220 230 240 250
RISSPAYINT FQRGSQESVW ETIPQPCWDD LTIGGRNGFL DLFVGDSQYS
260 270 280 290 300
AQFKYTNAPD ADARAIQATY WANQWAKEHG VNLSQYVKKA SRMGDYLRYA
310 320 330 340 350
MFDKYFRKIG DSKQAGTGYD AAHYLLSWYY AWGGGITADW AWIIGCSHVH
360 370 380 390 400
AGYQNPMTAW ILANDPEFKP ESPNGANDWA KSLERQLEFY QWLQSAEGAI
410 420 430 440 450
AGGATNSYKG RYETLPAGIS TFYGMAYEEH PVYLDPGSNT WFGFQAWTMQ
460 470 480 490 500
RVAEYYYLTG DTRAEQLLDK WVDWIKSVVR LNSDGTFEIP GNLEWSGQPD
510 520 530 540 550
TWTGTYTGNP NLHVSVVSYG TDLGAAGSLA NALLYYAKTS GDDEARNLAK
560 570 580 590 600
ELLDRMWNLY RDDKGLSAPE TREDYVRFFE QEVYVPQGWS GTMPNGDRIE
610 620 630 640 650
PGVTFLDIRS KYLNDPDYPK LQQAYNEGKA PVFNYHRFWA QCDIAIANGL
660 670 680 690 700
YSILFGSEQA NDSFITPTSA TFDKNNQEDI SVTVTYNGNT LLGIKSGSSY
710 720 730 740 750
LIEGVDYIVN GDVIIIKKEF LAGQATGSIS LLFDFSAGLD RTLTIDIIDT
760 770 780 790 800
GGGEEPVEPV EPVEGVLIIQ SFNANTQEIS NSIMPRFRIY NSGNTSIPLS
810 820 830 840 850
EVKLRYYYTV DGDKPQNFWC DWASIGSSNV TGTFVKMDGA TTGADYYLEI
860 870 880 890 900
GFTPQAGTLE PGASIEVQGR FSKIDWTDYT QTNDYSFNPT ASSYVDFNKI
910
TAYISGNLVY GIEP
Length:914
Mass (Da):102,921
Last modified:June 26, 2013 - v2
Checksum:iB24CFC80F3AF4C7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti520G → R in CAA93280 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69359 Genomic DNA Translation: CAA93280.1
CP004044 Genomic DNA Translation: AGC68874.1
RefSeqiWP_015359554.1, NC_020887.2

Genome annotation databases

EnsemblBacteriaiAGC68874; AGC68874; Cst_c18970
KEGGicss:Cst_c18970
PATRICifig|1121335.3.peg.1896

Similar proteinsi

Entry informationi

Entry nameiGUX2_CLOSH
AccessioniPrimary (citable) accession number: P50900
Secondary accession number(s): L7VQ95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 26, 2013
Last modified: March 28, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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