Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Palmitoyl-protein thioesterase 1

Gene

PPT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748).1 Publication

Catalytic activityi

Palmitoyl-[protein] + H2O = palmitate + [protein].By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei115By similarity1
Active sitei233By similarity1
Active sitei289By similarity1

GO - Molecular functioni

  • palmitoyl-(protein) hydrolase activity Source: UniProtKB
  • palmitoyl-CoA hydrolase activity Source: UniProtKB

GO - Biological processi

  • adult locomotory behavior Source: Ensembl
  • associative learning Source: Ensembl
  • brain development Source: UniProtKB
  • cellular protein catabolic process Source: Ensembl
  • chemical synaptic transmission Source: GO_Central
  • cofactor metabolic process Source: UniProtKB
  • cofactor transport Source: UniProtKB
  • grooming behavior Source: Ensembl
  • lipid catabolic process Source: UniProtKB
  • long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
  • lysosomal lumen acidification Source: UniProtKB
  • membrane raft organization Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of neuron apoptotic process Source: UniProtKB
  • nervous system development Source: UniProtKB
  • neuron development Source: UniProtKB
  • neurotransmitter secretion Source: Ensembl
  • pinocytosis Source: MGI
  • positive regulation of pinocytosis Source: UniProtKB
  • positive regulation of receptor-mediated endocytosis Source: UniProtKB
  • protein catabolic process Source: UniProtKB
  • protein depalmitoylation Source: UniProtKB
  • protein transport Source: UniProtKB
  • receptor-mediated endocytosis Source: MGI
  • regulation of phospholipase A2 activity Source: Ensembl
  • regulation of synapse structure or activity Source: UniProtKB
  • response to stimulus Source: UniProtKB-KW
  • sphingolipid catabolic process Source: UniProtKB
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Enzyme and pathway databases

BioCyciZFISH:HS05505-MONOMER.
BRENDAi3.1.2.2. 2681.
3.1.2.22. 2681.
ReactomeiR-HSA-75876. Synthesis of very long-chain fatty acyl-CoAs.

Protein family/group databases

ESTHERihuman-PPT1. Palmitoyl-protein_thioesterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyl-protein thioesterase 1 (EC:3.1.2.22)
Short name:
PPT-1
Alternative name(s):
Palmitoyl-protein hydrolase 1
Gene namesi
Name:PPT1
Synonyms:CLN11 Publication, PPT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:9325. PPT1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB
  • cytosol Source: UniProtKB
  • dendrite Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: Ensembl
  • Golgi apparatus Source: UniProtKB
  • lysosomal lumen Source: Reactome
  • lysosome Source: UniProtKB
  • membrane Source: UniProtKB
  • membrane raft Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • nucleus Source: UniProtKB
  • synaptic vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

Pathology & Biotechi

Involvement in diseasei

Ceroid lipofuscinosis, neuronal, 1 (CLN1)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of neuronal ceroid lipofuscinosis with variable age at onset. Infantile, late-infantile, juvenile, and adult onset have been reported. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN1 is referred to as granular osmiophilic deposits (GROD).
See also OMIM:256730
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05843438W → C in CLN1. 1 PublicationCorresponds to variant rs386833626dbSNPEnsembl.1
Natural variantiVAR_00554839H → Q in CLN1. Corresponds to variant rs386833627dbSNPEnsembl.1
Natural variantiVAR_00554942G → E in CLN1. Corresponds to variant rs386833631dbSNPEnsembl.1
Natural variantiVAR_06687445C → Y in CLN1. 1 PublicationCorresponds to variant rs137852702dbSNPEnsembl.1
Natural variantiVAR_00555075T → P in CLN1; juvenile onset. 2 PublicationsCorresponds to variant rs137852696dbSNPEnsembl.1
Natural variantiVAR_00555179D → G in CLN1; juvenile onset. 2 PublicationsCorresponds to variant rs137852697dbSNPEnsembl.1
Natural variantiVAR_018511108G → R in CLN1; onset in adulthood; retained in the endoplasmic reticulum rather than reaching the lysosome. 3 PublicationsCorresponds to variant rs137852701dbSNPEnsembl.1
Natural variantiVAR_005552109Y → D in CLN1; late infantile form. 1 PublicationCorresponds to variant rs386833642dbSNPEnsembl.1
Natural variantiVAR_005553122R → W in CLN1; retained in the endoplasmic reticulum rather than reaching the lysosome. 2 PublicationsCorresponds to variant rs137852695dbSNPEnsembl.1
Natural variantiVAR_066875138S → L in CLN1. 1 PublicationCorresponds to variant rs386833646dbSNPEnsembl.1
Natural variantiVAR_066876152C → Y in CLN1. 1 PublicationCorresponds to variant rs386833647dbSNPEnsembl.1
Natural variantiVAR_005555177Q → E in CLN1; late infantile form. 1 PublicationCorresponds to variant rs386833650dbSNPEnsembl.1
Natural variantiVAR_005556181V → L in CLN1. Corresponds to variant rs148412181dbSNPEnsembl.1
Natural variantiVAR_005557181V → M in CLN1; late infantile form. 1 PublicationCorresponds to variant rs148412181dbSNPEnsembl.1
Natural variantiVAR_066877187H → R in CLN1. 1 PublicationCorresponds to variant rs386833657dbSNPEnsembl.1
Natural variantiVAR_066878189P → R in CLN1. 1 PublicationCorresponds to variant rs386833658dbSNPEnsembl.1
Natural variantiVAR_005558219L → Q in CLN1; juvenile onset. 2 PublicationsCorresponds to variant rs137852698dbSNPEnsembl.1
Natural variantiVAR_066879222L → P in CLN1; late infantile form. 1 PublicationCorresponds to variant rs386833661dbSNPEnsembl.1
Natural variantiVAR_066880228V → G in CLN1. 1 PublicationCorresponds to variant rs386833663dbSNPEnsembl.1
Natural variantiVAR_005559247Y → H in CLN1. 1 PublicationCorresponds to variant rs386833665dbSNPEnsembl.1
Natural variantiVAR_005560250G → V in CLN1. 1 PublicationCorresponds to variant rs386833666dbSNPEnsembl.1
Natural variantiVAR_066881296W → R in CLN1. 1 PublicationCorresponds to variant rs386833669dbSNPEnsembl.1
Natural variantiVAR_066882305L → P in CLN1. 1 PublicationCorresponds to variant rs386833671dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Neuronal ceroid lipofuscinosis

Organism-specific databases

DisGeNETi5538.
MalaCardsiPPT1.
MIMi256730. phenotype.
OpenTargetsiENSG00000131238.
Orphaneti228329. CLN1 disease.
PharmGKBiPA33688.

Chemistry databases

ChEMBLiCHEMBL2331051.

Polymorphism and mutation databases

BioMutaiPPT1.
DMDMi1709747.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Combined sourcesAdd BLAST27
ChainiPRO_000002555028 – 306Palmitoyl-protein thioesterase 1Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 461 Publication
Disulfide bondi96 ↔ 1281 Publication
Disulfide bondi152 ↔ 1601 Publication
Glycosylationi197N-linked (GlcNAc...)1 Publication1
Glycosylationi212N-linked (GlcNAc...)1 Publication1
Glycosylationi232N-linked (GlcNAc...)2 Publications1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP50897.
PaxDbiP50897.
PeptideAtlasiP50897.
PRIDEiP50897.

PTM databases

iPTMnetiP50897.
PhosphoSitePlusiP50897.
SwissPalmiP50897.

Expressioni

Gene expression databases

BgeeiENSG00000131238.
CleanExiHS_PPT1.
ExpressionAtlasiP50897. baseline and differential.
GenevisibleiP50897. HS.

Organism-specific databases

HPAiHPA021546.

Interactioni

Subunit structurei

Interacts with CLN5 (PubMed:19941651). Interacts with ATP5A1 and ATP5B (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi111530. 37 interactors.
IntActiP50897. 7 interactors.
MINTiMINT-3018663.
STRINGi9606.ENSP00000394863.

Chemistry databases

BindingDBiP50897.

Structurei

Secondary structure

1306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 38Combined sources4
Turni48 – 50Combined sources3
Helixi51 – 61Combined sources11
Beta strandi67 – 69Combined sources3
Beta strandi73 – 75Combined sources3
Helixi76 – 85Combined sources10
Helixi88 – 101Combined sources14
Helixi103 – 105Combined sources3
Beta strandi109 – 114Combined sources6
Helixi116 – 127Combined sources12
Beta strandi133 – 140Combined sources8
Beta strandi153 – 155Combined sources3
Helixi157 – 170Combined sources14
Helixi174 – 177Combined sources4
Helixi181 – 185Combined sources5
Beta strandi189 – 191Combined sources3
Helixi192 – 198Combined sources7
Helixi202 – 205Combined sources4
Beta strandi208 – 210Combined sources3
Helixi213 – 220Combined sources8
Beta strandi223 – 230Combined sources8
Beta strandi234 – 238Combined sources5
Helixi239 – 243Combined sources5
Helixi258 – 260Combined sources3
Helixi262 – 265Combined sources4
Beta strandi268 – 270Combined sources3
Helixi271 – 276Combined sources6
Beta strandi280 – 288Combined sources9
Helixi294 – 300Combined sources7
Helixi302 – 305Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GROX-ray2.53A/B22-306[»]
ProteinModelPortaliP50897.
SMRiP50897.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50897.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2541. Eukaryota.
COG1075. LUCA.
GeneTreeiENSGT00530000063368.
HOGENOMiHOG000199232.
HOVERGENiHBG018186.
InParanoidiP50897.
KOiK01074.
OMAiLQETTLY.
OrthoDBiEOG091G0HJH.
PhylomeDBiP50897.
TreeFamiTF323926.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002472. Palm_thioest.
IPR030294. PPT1.
[Graphical view]
PANTHERiPTHR11247:SF8. PTHR11247:SF8. 1 hit.
PfamiPF02089. Palm_thioest. 1 hit.
[Graphical view]
PRINTSiPR00414. PPTHIESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P50897-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPGCLWLL AVALLPWTCA SRALQHLDPP APLPLVIWHG MGDSCCNPLS
60 70 80 90 100
MGAIKKMVEK KIPGIYVLSL EIGKTLMEDV ENSFFLNVNS QVTTVCQALA
110 120 130 140 150
KDPKLQQGYN AMGFSQGGQF LRAVAQRCPS PPMINLISVG GQHQGVFGLP
160 170 180 190 200
RCPGESSHIC DFIRKTLNAG AYSKVVQERL VQAEYWHDPI KEDVYRNHSI
210 220 230 240 250
FLADINQERG INESYKKNLM ALKKFVMVKF LNDSIVDPVD SEWFGFYRSG
260 270 280 290 300
QAKETIPLQE TSLYTQDRLG LKEMDNAGQL VFLATEGDHL QLSEEWFYAH

IIPFLG
Length:306
Mass (Da):34,193
Last modified:October 1, 1996 - v1
Checksum:i69F8083FD1C15E92
GO
Isoform 2 (identifier: P50897-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-144: Missing.

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):23,094
Checksum:iC73DB3FEBDEC8F32
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05843438W → C in CLN1. 1 PublicationCorresponds to variant rs386833626dbSNPEnsembl.1
Natural variantiVAR_00554839H → Q in CLN1. Corresponds to variant rs386833627dbSNPEnsembl.1
Natural variantiVAR_00554942G → E in CLN1. Corresponds to variant rs386833631dbSNPEnsembl.1
Natural variantiVAR_06687445C → Y in CLN1. 1 PublicationCorresponds to variant rs137852702dbSNPEnsembl.1
Natural variantiVAR_00555075T → P in CLN1; juvenile onset. 2 PublicationsCorresponds to variant rs137852696dbSNPEnsembl.1
Natural variantiVAR_00555179D → G in CLN1; juvenile onset. 2 PublicationsCorresponds to variant rs137852697dbSNPEnsembl.1
Natural variantiVAR_018511108G → R in CLN1; onset in adulthood; retained in the endoplasmic reticulum rather than reaching the lysosome. 3 PublicationsCorresponds to variant rs137852701dbSNPEnsembl.1
Natural variantiVAR_005552109Y → D in CLN1; late infantile form. 1 PublicationCorresponds to variant rs386833642dbSNPEnsembl.1
Natural variantiVAR_005553122R → W in CLN1; retained in the endoplasmic reticulum rather than reaching the lysosome. 2 PublicationsCorresponds to variant rs137852695dbSNPEnsembl.1
Natural variantiVAR_005554134I → T.1 PublicationCorresponds to variant rs1800205dbSNPEnsembl.1
Natural variantiVAR_066875138S → L in CLN1. 1 PublicationCorresponds to variant rs386833646dbSNPEnsembl.1
Natural variantiVAR_066876152C → Y in CLN1. 1 PublicationCorresponds to variant rs386833647dbSNPEnsembl.1
Natural variantiVAR_005555177Q → E in CLN1; late infantile form. 1 PublicationCorresponds to variant rs386833650dbSNPEnsembl.1
Natural variantiVAR_005556181V → L in CLN1. Corresponds to variant rs148412181dbSNPEnsembl.1
Natural variantiVAR_005557181V → M in CLN1; late infantile form. 1 PublicationCorresponds to variant rs148412181dbSNPEnsembl.1
Natural variantiVAR_066877187H → R in CLN1. 1 PublicationCorresponds to variant rs386833657dbSNPEnsembl.1
Natural variantiVAR_066878189P → R in CLN1. 1 PublicationCorresponds to variant rs386833658dbSNPEnsembl.1
Natural variantiVAR_005558219L → Q in CLN1; juvenile onset. 2 PublicationsCorresponds to variant rs137852698dbSNPEnsembl.1
Natural variantiVAR_066879222L → P in CLN1; late infantile form. 1 PublicationCorresponds to variant rs386833661dbSNPEnsembl.1
Natural variantiVAR_066880228V → G in CLN1. 1 PublicationCorresponds to variant rs386833663dbSNPEnsembl.1
Natural variantiVAR_005559247Y → H in CLN1. 1 PublicationCorresponds to variant rs386833665dbSNPEnsembl.1
Natural variantiVAR_005560250G → V in CLN1. 1 PublicationCorresponds to variant rs386833666dbSNPEnsembl.1
Natural variantiVAR_066881296W → R in CLN1. 1 PublicationCorresponds to variant rs386833669dbSNPEnsembl.1
Natural variantiVAR_066882305L → P in CLN1. 1 PublicationCorresponds to variant rs386833671dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04203342 – 144Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42809 Genomic DNA. Translation: AAA85337.1.
U44772 mRNA. Translation: AAB06236.1.
AF022211
, AF022203, AF022204, AF022205, AF022206, AF022207, AF022208, AF022209, AF022210 Genomic DNA. Translation: AAB72224.1.
AK302232 mRNA. Translation: BAG63586.1.
AK312287 mRNA. Translation: BAG35214.1.
CR542053 mRNA. Translation: CAG46850.1.
AL512599 Genomic DNA. Translation: CAI11025.1.
CH471059 Genomic DNA. Translation: EAX07237.1.
CH471059 Genomic DNA. Translation: EAX07238.1.
BC008426 mRNA. Translation: AAH08426.1.
CCDSiCCDS44119.1. [P50897-2]
CCDS447.1. [P50897-1]
PIRiI58097.
RefSeqiNP_000301.1. NM_000310.3. [P50897-1]
NP_001136076.1. NM_001142604.1. [P50897-2]
UniGeneiHs.3873.

Genome annotation databases

EnsembliENST00000433473; ENSP00000394863; ENSG00000131238. [P50897-1]
ENST00000449045; ENSP00000392293; ENSG00000131238. [P50897-2]
ENST00000529905; ENSP00000432053; ENSG00000131238. [P50897-1]
GeneIDi5538.
KEGGihsa:5538.
UCSCiuc001cfb.3. human. [P50897-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NCL CLN1

Neural Ceroid Lipofuscinoses mutation db

Mutations of the PPT1 gene

Retina International's Scientific Newsletter

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42809 Genomic DNA. Translation: AAA85337.1.
U44772 mRNA. Translation: AAB06236.1.
AF022211
, AF022203, AF022204, AF022205, AF022206, AF022207, AF022208, AF022209, AF022210 Genomic DNA. Translation: AAB72224.1.
AK302232 mRNA. Translation: BAG63586.1.
AK312287 mRNA. Translation: BAG35214.1.
CR542053 mRNA. Translation: CAG46850.1.
AL512599 Genomic DNA. Translation: CAI11025.1.
CH471059 Genomic DNA. Translation: EAX07237.1.
CH471059 Genomic DNA. Translation: EAX07238.1.
BC008426 mRNA. Translation: AAH08426.1.
CCDSiCCDS44119.1. [P50897-2]
CCDS447.1. [P50897-1]
PIRiI58097.
RefSeqiNP_000301.1. NM_000310.3. [P50897-1]
NP_001136076.1. NM_001142604.1. [P50897-2]
UniGeneiHs.3873.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GROX-ray2.53A/B22-306[»]
ProteinModelPortaliP50897.
SMRiP50897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111530. 37 interactors.
IntActiP50897. 7 interactors.
MINTiMINT-3018663.
STRINGi9606.ENSP00000394863.

Chemistry databases

BindingDBiP50897.
ChEMBLiCHEMBL2331051.

Protein family/group databases

ESTHERihuman-PPT1. Palmitoyl-protein_thioesterase.

PTM databases

iPTMnetiP50897.
PhosphoSitePlusiP50897.
SwissPalmiP50897.

Polymorphism and mutation databases

BioMutaiPPT1.
DMDMi1709747.

Proteomic databases

EPDiP50897.
PaxDbiP50897.
PeptideAtlasiP50897.
PRIDEiP50897.

Protocols and materials databases

DNASUi5538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000433473; ENSP00000394863; ENSG00000131238. [P50897-1]
ENST00000449045; ENSP00000392293; ENSG00000131238. [P50897-2]
ENST00000529905; ENSP00000432053; ENSG00000131238. [P50897-1]
GeneIDi5538.
KEGGihsa:5538.
UCSCiuc001cfb.3. human. [P50897-1]

Organism-specific databases

CTDi5538.
DisGeNETi5538.
GeneCardsiPPT1.
GeneReviewsiPPT1.
HGNCiHGNC:9325. PPT1.
HPAiHPA021546.
MalaCardsiPPT1.
MIMi256730. phenotype.
600722. gene.
neXtProtiNX_P50897.
OpenTargetsiENSG00000131238.
Orphaneti228329. CLN1 disease.
PharmGKBiPA33688.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2541. Eukaryota.
COG1075. LUCA.
GeneTreeiENSGT00530000063368.
HOGENOMiHOG000199232.
HOVERGENiHBG018186.
InParanoidiP50897.
KOiK01074.
OMAiLQETTLY.
OrthoDBiEOG091G0HJH.
PhylomeDBiP50897.
TreeFamiTF323926.

Enzyme and pathway databases

BioCyciZFISH:HS05505-MONOMER.
BRENDAi3.1.2.2. 2681.
3.1.2.22. 2681.
ReactomeiR-HSA-75876. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

ChiTaRSiPPT1. human.
EvolutionaryTraceiP50897.
GeneWikiiPPT1.
GenomeRNAii5538.
PROiP50897.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131238.
CleanExiHS_PPT1.
ExpressionAtlasiP50897. baseline and differential.
GenevisibleiP50897. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002472. Palm_thioest.
IPR030294. PPT1.
[Graphical view]
PANTHERiPTHR11247:SF8. PTHR11247:SF8. 1 hit.
PfamiPF02089. Palm_thioest. 1 hit.
[Graphical view]
PRINTSiPR00414. PPTHIESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPT1_HUMAN
AccessioniPrimary (citable) accession number: P50897
Secondary accession number(s): B4DY24, Q6FGQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 170 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.