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Protein

Protein PSP1

Gene

PSP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DNA polymerase alpha mutation suppressor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30026-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PSP1
Alternative name(s):
Growth inhibitory protein 5
Polymerase suppressor protein 1
Gene namesi
Name:PSP1
Synonyms:GIN5
Ordered Locus Names:YDR505C
ORF Names:D9719.11
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR505C.
SGDiS000002913. PSP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic mRNA processing body Source: SGD
  • mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000970681 – 841Protein PSP1Add BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei334PhosphothreonineCombined sources1
Modified residuei520PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP50896.
PRIDEiP50896.

PTM databases

iPTMnetiP50896.

Interactioni

Protein-protein interaction databases

BioGridi32556. 69 interactors.
DIPiDIP-5018N.
IntActiP50896. 7 interactors.
MINTiMINT-508587.

Structurei

3D structure databases

ProteinModelPortaliP50896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini653 – 765PSP1 C-terminalPROSITE-ProRule annotationAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi98 – 101Poly-Gln4
Compositional biasi139 – 144Poly-Asn6
Compositional biasi314 – 320Poly-Asn7
Compositional biasi348 – 359Poly-GlnAdd BLAST12

Sequence similaritiesi

Belongs to the PSP1 family.Curated
Contains 1 PSP1 C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000067658.
InParanoidiP50896.
OrthoDBiEOG092C39M5.

Family and domain databases

InterProiIPR007557. PSP1_C.
[Graphical view]
PfamiPF04468. PSP1. 1 hit.
[Graphical view]
PROSITEiPS51411. PSP1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPTVNSTT SISDNVDLKN YYEDLLFKNN SGKSLSDLPR KLNDNSNNSG
60 70 80 90 100
SDTVDPLAGL NNLRNSIKSA GNGMENRRTF DDIDFMGRFP YLPPVPNQQQ
110 120 130 140 150
QPFSHQNGFI QEHPSSNLTS FQMSSSNSEP MSAPPISSNN NNLNSTQMGN
160 170 180 190 200
YQAQQRSFPQ FNGNSFHSNG NDLMGNRMDS DYMRLMNKTN IGFTSNSGSN
210 220 230 240 250
FAAPSHSAGN PSSMNNQQVP SFNWQQPSHP ESTIRRSSYI SDTLINHQMP
260 270 280 290 300
DARQKQTSQV QQQHAQGFNL FNSRFNYDNL NSTHLTAKGV PEFGNGVQPP
310 320 330 340 350
YPYDNEPNNA SISNSNNNNN SHNMVPMQQF RRNTQPVASF NPSLPTFQQQ
360 370 380 390 400
QQQPQQPQQP RNVNVPTSFN GERVDDVQLV QLQRSSSVPS STNSHNLQNE
410 420 430 440 450
NSNEGNVSLD NGLVLIQGKH LTSSKTLHDL YSDCGSGYFA SSAVFEFTDN
460 470 480 490 500
IKKMLKLHDS NESYDAKNMG LIDEEGNTYQ SLLNFLDILR SCNMNYVNDP
510 520 530 540 550
ESNNGIVSNN GGNKNRRKGS FTTELSCRNA NNSFLPYTPL VLVALKNGKL
560 570 580 590 600
ELLSTPQATN LLLKRGDLVI IDGDRGRDLV LVVEPSVDLN LALFINFLKK
610 620 630 640 650
KIHFDSLITS ESQHYRNDEF IQMLIDSKNG QKKKLNPKLY DVVELTELII
660 670 680 690 700
PSKQVLRFAT PWEVTTNLHN KFEDELKALH IAQSKLQALN DNSKSQNTND
710 720 730 740 750
SSSNNFTNAA TYSKPKLNIK ILNAEFQFDR KKLTFYYVCE ERNDFRDLIK
760 770 780 790 800
ELFKYYKTRI WLCAIPNNLS IDSKYYDKQQ KELKLYQNIV KNYNAEDLMN
810 820 830 840
VNEFSQNRGN NRVNFAPPLN EIELDNFQIA VYEELVHELF H
Length:841
Mass (Da):95,348
Last modified:July 27, 2011 - v2
Checksum:i03B5C27F96F71F2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116S → C in AAA93076 (PubMed:9529527).Curated1
Sequence conflicti122 – 133QMSSS…EPMSA → KCLRLIQSCVP in AAA93076 (PubMed:9529527).CuratedAdd BLAST12
Sequence conflicti198 – 210GSNFA…HSAGN → RAILLPHHTVLAT in AAA93076 (PubMed:9529527).CuratedAdd BLAST13
Sequence conflicti732K → E in AAB64947 (PubMed:9169867).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33115 Genomic DNA. Translation: AAA93076.1.
U33057 Genomic DNA. Translation: AAB64947.1.
BK006938 Genomic DNA. Translation: DAA12337.2.
PIRiS69563.
RefSeqiNP_010793.2. NM_001180813.2.

Genome annotation databases

EnsemblFungiiYDR505C; YDR505C; YDR505C.
GeneIDi852116.
KEGGisce:YDR505C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33115 Genomic DNA. Translation: AAA93076.1.
U33057 Genomic DNA. Translation: AAB64947.1.
BK006938 Genomic DNA. Translation: DAA12337.2.
PIRiS69563.
RefSeqiNP_010793.2. NM_001180813.2.

3D structure databases

ProteinModelPortaliP50896.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32556. 69 interactors.
DIPiDIP-5018N.
IntActiP50896. 7 interactors.
MINTiMINT-508587.

PTM databases

iPTMnetiP50896.

Proteomic databases

MaxQBiP50896.
PRIDEiP50896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR505C; YDR505C; YDR505C.
GeneIDi852116.
KEGGisce:YDR505C.

Organism-specific databases

EuPathDBiFungiDB:YDR505C.
SGDiS000002913. PSP1.

Phylogenomic databases

GeneTreeiENSGT00530000067658.
InParanoidiP50896.
OrthoDBiEOG092C39M5.

Enzyme and pathway databases

BioCyciYEAST:G3O-30026-MONOMER.

Miscellaneous databases

PROiP50896.

Family and domain databases

InterProiIPR007557. PSP1_C.
[Graphical view]
PfamiPF04468. PSP1. 1 hit.
[Graphical view]
PROSITEiPS51411. PSP1_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSP1_YEAST
AccessioniPrimary (citable) accession number: P50896
Secondary accession number(s): D6VTC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.