PSP1

Functionⁱ

DNA polymerase alpha mutation suppressor.

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-30026-MONOMER.

BioCycⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein PSP1 Alternative name(s): Growth inhibitory protein 5 Polymerase suppressor protein 1
Gene namesⁱ	Name:PSP1 Synonyms:GIN5 Ordered Locus Names:YDR505C ORF Names:D9719.11
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IV

Organism-specific databases

EuPathDBⁱ	FungiDB:YDR505C.
Saccharomyces Genome Database More...SGDⁱ	S000002913. PSP1.

Subcellular locationⁱ

GO - Cellular componentⁱ

mitochondrion Source: UniProtKB-SubCell
P-body
Source: SGD
Inferred from direct assayⁱ
- 23222640

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000097068	1 – 841	Protein PSP1Add BLAST		841

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	31	PhosphoserineCombined sources	1
Modified residueⁱ	34	PhosphoserineCombined sources	1
Modified residueⁱ	36	PhosphoserineCombined sources	1
Modified residueⁱ	237	PhosphoserineCombined sources	1
Modified residueⁱ	334	PhosphothreonineCombined sources	1
Modified residueⁱ	520	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P50896.
PRIDEⁱ	P50896.

PTM databases

iPTMnetⁱ	P50896.

iPTMnetⁱ

P50896.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	32556. 126 interactors.
Database of interacting proteins More...DIPⁱ	DIP-5018N.
IntActⁱ	P50896. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-508587.
STRINGⁱ	4932.YDR505C.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	653 – 765	PSP1 C-terminalPROSITE-ProRule annotationAdd BLAST		113

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	98 – 101	Poly-Gln	4
Compositional biasⁱ	139 – 144	Poly-Asn	6
Compositional biasⁱ	314 – 320	Poly-Asn	7
Compositional biasⁱ	348 – 359	Poly-GlnAdd BLAST	12

Sequence similaritiesⁱ

Belongs to the PSP1 family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000067658.
InParanoidⁱ	P50896.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C39M5.

Family and domain databases

InterProⁱ	View protein in InterPro IPR007557. PSP1_C.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04468. PSP1. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51411. PSP1_C. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P50896-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDLPTVNSTT SISDNVDLKN YYEDLLFKNN SGKSLSDLPR KLNDNSNNSG 
        60         70         80         90        100
SDTVDPLAGL NNLRNSIKSA GNGMENRRTF DDIDFMGRFP YLPPVPNQQQ 
       110        120        130        140        150
QPFSHQNGFI QEHPSSNLTS FQMSSSNSEP MSAPPISSNN NNLNSTQMGN 
       160        170        180        190        200
YQAQQRSFPQ FNGNSFHSNG NDLMGNRMDS DYMRLMNKTN IGFTSNSGSN 
       210        220        230        240        250
FAAPSHSAGN PSSMNNQQVP SFNWQQPSHP ESTIRRSSYI SDTLINHQMP 
       260        270        280        290        300
DARQKQTSQV QQQHAQGFNL FNSRFNYDNL NSTHLTAKGV PEFGNGVQPP 
       310        320        330        340        350
YPYDNEPNNA SISNSNNNNN SHNMVPMQQF RRNTQPVASF NPSLPTFQQQ 
       360        370        380        390        400
QQQPQQPQQP RNVNVPTSFN GERVDDVQLV QLQRSSSVPS STNSHNLQNE 
       410        420        430        440        450
NSNEGNVSLD NGLVLIQGKH LTSSKTLHDL YSDCGSGYFA SSAVFEFTDN 
       460        470        480        490        500
IKKMLKLHDS NESYDAKNMG LIDEEGNTYQ SLLNFLDILR SCNMNYVNDP 
       510        520        530        540        550
ESNNGIVSNN GGNKNRRKGS FTTELSCRNA NNSFLPYTPL VLVALKNGKL 
       560        570        580        590        600
ELLSTPQATN LLLKRGDLVI IDGDRGRDLV LVVEPSVDLN LALFINFLKK 
       610        620        630        640        650
KIHFDSLITS ESQHYRNDEF IQMLIDSKNG QKKKLNPKLY DVVELTELII 
       660        670        680        690        700
PSKQVLRFAT PWEVTTNLHN KFEDELKALH IAQSKLQALN DNSKSQNTND 
       710        720        730        740        750
SSSNNFTNAA TYSKPKLNIK ILNAEFQFDR KKLTFYYVCE ERNDFRDLIK 
       760        770        780        790        800
ELFKYYKTRI WLCAIPNNLS IDSKYYDKQQ KELKLYQNIV KNYNAEDLMN 
       810        820        830        840 
VNEFSQNRGN NRVNFAPPLN EIELDNFQIA VYEELVHELF H

Length:841

Mass (Da):95,348

Last modified:July 27, 2011 - v2

Checksum:ⁱ03B5C27F96F71F2C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	116	S → C in AAA93076 (PubMed:9529527).Curated	1
Sequence conflictⁱ	122 – 133	QMSSS…EPMSA → KCLRLIQSCVP in AAA93076 (PubMed:9529527).CuratedAdd BLAST	12
Sequence conflictⁱ	198 – 210	GSNFA…HSAGN → RAILLPHHTVLAT in AAA93076 (PubMed:9529527).CuratedAdd BLAST	13
Sequence conflictⁱ	732	K → E in AAB64947 (PubMed:9169867).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U33115 Genomic DNA. Translation: AAA93076.1. U33057 Genomic DNA. Translation: AAB64947.1. BK006938 Genomic DNA. Translation: DAA12337.2.
PIRⁱ	S69563.
NCBI Reference Sequences More...RefSeqⁱ	NP_010793.2. NM_001180813.2.

Genome annotation databases

EnsemblFungiⁱ	YDR505C; YDR505C; YDR505C.
GeneIDⁱ	852116.
KEGGⁱ	sce:YDR505C.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U33115 Genomic DNA. Translation: AAA93076.1. U33057 Genomic DNA. Translation: AAB64947.1. BK006938 Genomic DNA. Translation: DAA12337.2.
PIRⁱ	S69563.
NCBI Reference Sequences More...RefSeqⁱ	NP_010793.2. NM_001180813.2.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	32556. 126 interactors.
Database of interacting proteins More...DIPⁱ	DIP-5018N.
IntActⁱ	P50896. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-508587.
STRINGⁱ	4932.YDR505C.

PTM databases

iPTMnetⁱ	P50896.

iPTMnetⁱ

P50896.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P50896.
PRIDEⁱ	P50896.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YDR505C; YDR505C; YDR505C.
GeneIDⁱ	852116.
KEGGⁱ	sce:YDR505C.

Organism-specific databases

EuPathDBⁱ	FungiDB:YDR505C.
Saccharomyces Genome Database More...SGDⁱ	S000002913. PSP1.

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000067658.
InParanoidⁱ	P50896.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C39M5.

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-30026-MONOMER.

BioCycⁱ

YEAST:G3O-30026-MONOMER.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P50896.

PROⁱ

PR:P50896.

Family and domain databases

InterProⁱ	View protein in InterPro IPR007557. PSP1_C.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04468. PSP1. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51411. PSP1_C. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PSP1_YEAST
Accessionⁱ	P50896Primary (citable) accession number: P50896 Secondary accession number(s): D6VTC7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	July 27, 2011
	Last modified:	July 5, 2017
	This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P50896 (PSP1_YEAST)

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Protein PSP1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ