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P50895

- BCAM_HUMAN

UniProt

P50895 - BCAM_HUMAN

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Protein

Basal cell adhesion molecule

Gene

BCAM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Laminin alpha-5 receptor. May mediate intracellular signaling.1 Publication

GO - Molecular functioni

  1. laminin binding Source: BHF-UCL
  2. laminin receptor activity Source: BHF-UCL
  3. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. cell adhesion Source: ProtInc
  2. cell-matrix adhesion Source: BHF-UCL
  3. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen, Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Basal cell adhesion molecule
Alternative name(s):
Auberger B antigen
B-CAM cell surface glycoprotein
F8/G253 antigen
Lutheran antigen
Lutheran blood group glycoprotein
CD_antigen: CD239
Gene namesi
Name:BCAM
Synonyms:LU, MSK19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6722. BCAM.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: BHF-UCL
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi621 – 6211S → A: Dramatically reduced cell adhesion. 1 Publication

Organism-specific databases

MIMi111200. phenotype.
247420. phenotype.
PharmGKBiPA30484.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 31311 PublicationAdd
BLAST
Chaini32 – 628597Basal cell adhesion moleculePRO_0000014850Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 1251 PublicationPROSITE-ProRule annotation
Disulfide bondi172 ↔ 2371 PublicationPROSITE-ProRule annotation
Disulfide bondi291 ↔ 3371 Publication
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi384 ↔ 4241 Publication
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)2 Publications
Disulfide bondi473 ↔ 5221 Publication
Modified residuei596 – 5961Phosphoserine; by GSK31 Publication
Modified residuei598 – 5981Phosphoserine; by CK21 Publication
Modified residuei621 – 6211Phosphoserine; by PKA1 Publication

Post-translational modificationi

Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP50895.
PaxDbiP50895.
PRIDEiP50895.

PTM databases

PhosphoSiteiP50895.

Expressioni

Tissue specificityi

Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.

Developmental stagei

Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up-regulated following malignant transformation in some cell types.

Gene expression databases

BgeeiP50895.
CleanExiHS_BCAM.
ExpressionAtlasiP50895. baseline and differential.
GenevestigatoriP50895.

Organism-specific databases

HPAiHPA005654.

Interactioni

Protein-protein interaction databases

BioGridi110237. 4 interactions.
MINTiMINT-5004331.
STRINGi9606.ENSP00000270233.

Structurei

Secondary structure

1
628
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 363Combined sources
Beta strandi39 – 446Combined sources
Beta strandi49 – 513Combined sources
Beta strandi54 – 574Combined sources
Beta strandi60 – 6910Combined sources
Beta strandi77 – 848Combined sources
Beta strandi87 – 926Combined sources
Beta strandi110 – 1145Combined sources
Helixi117 – 1193Combined sources
Beta strandi121 – 1288Combined sources
Helixi130 – 1323Combined sources
Beta strandi134 – 14512Combined sources
Beta strandi151 – 1544Combined sources
Beta strandi167 – 17913Combined sources
Beta strandi182 – 1876Combined sources
Beta strandi190 – 1923Combined sources
Beta strandi200 – 21011Combined sources
Beta strandi216 – 2249Combined sources
Helixi228 – 2325Combined sources
Beta strandi234 – 2429Combined sources
Helixi244 – 2463Combined sources
Beta strandi248 – 2525Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PETX-ray1.70A32-262[»]
2PF6X-ray2.20A/B32-262[»]
ProteinModelPortaliP50895.
SMRiP50895. Positions 32-532.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50895.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 547516ExtracellularSequence AnalysisAdd
BLAST
Topological domaini569 – 62860CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei548 – 56821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 142111Ig-like V-type 1Add
BLAST
Domaini147 – 257111Ig-like V-type 2Add
BLAST
Domaini274 – 35582Ig-like C2-type 1Add
BLAST
Domaini363 – 44179Ig-like C2-type 2Add
BLAST
Domaini448 – 54194Ig-like C2-type 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni309 – 3124Interaction with laminin alpha5

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150030.
GeneTreeiENSGT00530000063457.
HOGENOMiHOG000113409.
InParanoidiP50895.
KOiK06578.
OMAiHYPTEHV.
OrthoDBiEOG7GBFWH.
PhylomeDBiP50895.
TreeFamiTF330534.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50895-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPPDAPAQA RGAPRLLLLA VLLAAHPDAQ AEVRLSVPPL VEVMRGKSVI
60 70 80 90 100
LDCTPTGTHD HYMLEWFLTD RSGARPRLAS AEMQGSELQV TMHDTRGRSP
110 120 130 140 150
PYQLDSQGRL VLAEAQVGDE RDYVCVVRAG AAGTAEATAR LNVFAKPEAT
160 170 180 190 200
EVSPNKGTLS VMEDSAQEIA TCNSRNGNPA PKITWYRNGQ RLEVPVEMNP
210 220 230 240 250
EGYMTSRTVR EASGLLSLTS TLYLRLRKDD RDASFHCAAH YSLPEGRHGR
260 270 280 290 300
LDSPTFHLTL HYPTEHVQFW VGSPSTPAGW VREGDTVQLL CRGDGSPSPE
310 320 330 340 350
YTLFRLQDEQ EEVLNVNLEG NLTLEGVTRG QSGTYGCRVE DYDAADDVQL
360 370 380 390 400
SKTLELRVAY LDPLELSEGK VLSLPLNSSA VVNCSVHGLP TPALRWTKDS
410 420 430 440 450
TPLGDGPMLS LSSITFDSNG TYVCEASLPT VPVLSRTQNF TLLVQGSPEL
460 470 480 490 500
KTAEIEPKAD GSWREGDEVT LICSARGHPD PKLSWSQLGG SPAEPIPGRQ
510 520 530 540 550
GWVSSSLTLK VTSALSRDGI SCEASNPHGN KRHVFHFGTV SPQTSQAGVA
560 570 580 590 600
VMAVAVSVGL LLLVVAVFYC VRRKGGPCCR QRREKGAPPP GEPGLSHSGS
610 620
EQPEQTGLLM GGASGGARGG SGGFGDEC
Length:628
Mass (Da):67,405
Last modified:March 7, 2006 - v2
Checksum:iC88F4F5C640C3F5B
GO

Sequence cautioni

The sequence EAW57297.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2262RL → PC in CAA56327. (PubMed:7954395)Curated
Sequence conflicti355 – 3562EL → DV in CAA56327. (PubMed:7954395)Curated
Sequence conflicti532 – 5321R → L in ABY27636. 1 PublicationCurated

Polymorphismi

BCAM is responsible for the Lutheran blood group system (LU) [MIMi:111200]. Lutheran is a complex blood group system consisting of 19 antigens. Antigens Lu(a) and Lu(b) are defined by a polymorphism at position 77: Lu(a) has His-77 and Lu(b) has Arg-77.
Inactivating variants in BCAM are responsible for the recessive Lutheran null phenotype Lu(a-b-) of the Lutheran blood group [MIMi:247420]. Autosomal recessive inheritance of the Lutheran null blood group phenotype is extremely rare. There is no obvious associated clinical or hematologic pathology, and all patients have been identified through identification of anti-Lu3 antibodies in their serum.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771R → H Defines the Lu(a) antigen. 1 Publication
Corresponds to variant rs28399653 [ dbSNP | Ensembl ].
VAR_021348
Natural varianti196 – 1961V → I.1 Publication
Corresponds to variant rs28399654 [ dbSNP | Ensembl ].
VAR_021349
Natural varianti204 – 2041M → K.1 Publication
Corresponds to variant rs28399656 [ dbSNP | Ensembl ].
VAR_021350
Natural varianti282 – 2821R → H.1 Publication
Corresponds to variant rs9967601 [ dbSNP | Ensembl ].
VAR_021351
Natural varianti381 – 3811V → I.1 Publication
Corresponds to variant rs28399626 [ dbSNP | Ensembl ].
VAR_021352
Natural varianti451 – 4511K → Q.1 Publication
Corresponds to variant rs28399630 [ dbSNP | Ensembl ].
VAR_021353
Natural varianti539 – 5391T → A.3 Publications
Corresponds to variant rs1135062 [ dbSNP | Ensembl ].
VAR_021354
Natural varianti581 – 5811Q → L.1 Publication
Corresponds to variant rs28399659 [ dbSNP | Ensembl ].
VAR_021355

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83425 mRNA. Translation: CAA58449.1.
AY845133 Genomic DNA. Translation: AAV88096.1.
AC092306 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57297.1. Sequence problems.
BC050450 mRNA. Translation: AAH50450.1.
X80026 mRNA. Translation: CAA56327.1.
EU307108 Genomic DNA. Translation: ABY27636.1.
EU307109 Genomic DNA. Translation: ABY27637.1.
CCDSiCCDS12644.1.
PIRiI37202.
I38000.
RefSeqiNP_001013275.1. NM_001013257.2.
NP_005572.2. NM_005581.4.
UniGeneiHs.625725.

Genome annotation databases

EnsembliENST00000270233; ENSP00000270233; ENSG00000187244.
GeneIDi4059.
KEGGihsa:4059.
UCSCiuc002ozt.2. human.

Polymorphism databases

DMDMi92058724.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83425 mRNA. Translation: CAA58449.1 .
AY845133 Genomic DNA. Translation: AAV88096.1 .
AC092306 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57297.1 . Sequence problems.
BC050450 mRNA. Translation: AAH50450.1 .
X80026 mRNA. Translation: CAA56327.1 .
EU307108 Genomic DNA. Translation: ABY27636.1 .
EU307109 Genomic DNA. Translation: ABY27637.1 .
CCDSi CCDS12644.1.
PIRi I37202.
I38000.
RefSeqi NP_001013275.1. NM_001013257.2.
NP_005572.2. NM_005581.4.
UniGenei Hs.625725.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PET X-ray 1.70 A 32-262 [» ]
2PF6 X-ray 2.20 A/B 32-262 [» ]
ProteinModelPortali P50895.
SMRi P50895. Positions 32-532.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110237. 4 interactions.
MINTi MINT-5004331.
STRINGi 9606.ENSP00000270233.

PTM databases

PhosphoSitei P50895.

Polymorphism databases

DMDMi 92058724.

Proteomic databases

MaxQBi P50895.
PaxDbi P50895.
PRIDEi P50895.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270233 ; ENSP00000270233 ; ENSG00000187244 .
GeneIDi 4059.
KEGGi hsa:4059.
UCSCi uc002ozt.2. human.

Organism-specific databases

CTDi 4059.
GeneCardsi GC19P045312.
HGNCi HGNC:6722. BCAM.
HPAi HPA005654.
MIMi 111200. phenotype.
247420. phenotype.
612773. gene.
neXtProti NX_P50895.
PharmGKBi PA30484.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150030.
GeneTreei ENSGT00530000063457.
HOGENOMi HOG000113409.
InParanoidi P50895.
KOi K06578.
OMAi HYPTEHV.
OrthoDBi EOG7GBFWH.
PhylomeDBi P50895.
TreeFami TF330534.

Miscellaneous databases

ChiTaRSi BCAM. human.
EvolutionaryTracei P50895.
GeneWikii BCAM.
GenomeRNAii 4059.
NextBioi 15906.
PROi P50895.
SOURCEi Search...

Gene expression databases

Bgeei P50895.
CleanExi HS_BCAM.
ExpressionAtlasi P50895. baseline and differential.
Genevestigatori P50895.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver."
    Parsons S.F., Mallinson G., Holmes C.H., Houlihan J.M., Simpson K.L., Mawby W.J., Spurr N.K., Warne D., Barclay A.N., Anstee D.J.
    Proc. Natl. Acad. Sci. U.S.A. 92:5496-5500(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 32-67 AND 182-203, VARIANT ALA-539.
    Tissue: Placenta.
  2. SeattleSNPs variation discovery resource
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-77; ILE-196; LYS-204; HIS-282; ILE-381; GLN-451 AND LEU-581.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily."
    Campbell I.G., Foulkes W.D., Senger G., Trowsdale J., Garin-Chesa P., Rettig W.J.
    Cancer Res. 54:5761-5765(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-588, VARIANT ALA-539.
  7. "Molecular basis of Lub(-) individual among Chinese blood donors in Shanghai area."
    Wang C., Li Q., Guo Z., Yang Y., Zhu Z.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 492-539, VARIANT ALA-539.
  8. "Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms."
    Parsons S.F., Mallinson G., Daniels G.L., Green C.A., Smythe J.S., Anstee D.J.
    Blood 89:4219-4225(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: LU(A)/LU(B) POLYMORPHISM.
  9. "Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism."
    El Nemer W., Rahuel C., Colin Y., Gane P., Cartron J.P., Le Van Kim C.
    Blood 89:4608-4616(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: LU(A)/LU(B) POLYMORPHISM.
  10. "Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin."
    Udani M., Zen Q., Cottman M., Leonard N., Jefferson S., Daymont C., Truskey G., Telen M.J.
    J. Clin. Invest. 101:2550-2558(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-439.
  12. "Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5."
    Gauthier E., Rahuel C., Wautier M.P., El Nemer W., Gane P., Wautier J.L., Cartron J.P., Colin Y., Le Van Kim C.
    J. Biol. Chem. 280:30055-30062(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-596; SER-598 AND SER-621, MUTAGENESIS OF SER-621.
  13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-439.
    Tissue: Plasma.
  14. "Different inactivating mutations in the LU genes of three individuals with the Lutheran-null phenotype."
    Karamatic Crew V., Mallinson G., Green C., Poole J., Uchikawa M., Tani Y., Geisen C., Oldenburg J., Daniels G.
    Transfusion 47:492-498(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN THE LUTHERAN NULL PHENOTYPE.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3."
    Mankelow T.J., Burton N., Stefansdottir F.O., Spring F.A., Parsons S.F., Pedersen J.S., Oliveira C.L., Lammie D., Wess T., Mohandas N., Chasis J.A., Brady R.L., Anstee D.J.
    Blood 110:3398-3406(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 32-262, LAMININ-ALPHA5 BINDING REGION, DISULFIDE BONDS.

Entry informationi

Entry nameiBCAM_HUMAN
AccessioniPrimary (citable) accession number: P50895
Secondary accession number(s): A8MYF9
, A9YWT5, A9YWT6, Q86VC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3