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P50895

- BCAM_HUMAN

UniProt

P50895 - BCAM_HUMAN

Protein

Basal cell adhesion molecule

Gene

BCAM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Laminin alpha-5 receptor. May mediate intracellular signaling.1 Publication

    GO - Molecular functioni

    1. laminin binding Source: BHF-UCL
    2. laminin receptor activity Source: BHF-UCL
    3. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. cell adhesion Source: ProtInc
    2. cell-matrix adhesion Source: BHF-UCL
    3. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Blood group antigen, Receptor

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Basal cell adhesion molecule
    Alternative name(s):
    Auberger B antigen
    B-CAM cell surface glycoprotein
    F8/G253 antigen
    Lutheran antigen
    Lutheran blood group glycoprotein
    CD_antigen: CD239
    Gene namesi
    Name:BCAM
    Synonyms:LU, MSK19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6722. BCAM.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: BHF-UCL
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi621 – 6211S → A: Dramatically reduced cell adhesion. 1 Publication

    Organism-specific databases

    MIMi111200. phenotype.
    247420. phenotype.
    PharmGKBiPA30484.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 31311 PublicationAdd
    BLAST
    Chaini32 – 628597Basal cell adhesion moleculePRO_0000014850Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 1251 PublicationPROSITE-ProRule annotation
    Disulfide bondi172 ↔ 2371 PublicationPROSITE-ProRule annotation
    Disulfide bondi291 ↔ 3371 Publication
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi384 ↔ 4241 Publication
    Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)2 Publications
    Disulfide bondi473 ↔ 5221 Publication
    Modified residuei596 – 5961Phosphoserine; by GSK31 Publication
    Modified residuei598 – 5981Phosphoserine; by CK21 Publication
    Modified residuei621 – 6211Phosphoserine; by PKA1 Publication

    Post-translational modificationi

    Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP50895.
    PaxDbiP50895.
    PRIDEiP50895.

    PTM databases

    PhosphoSiteiP50895.

    Expressioni

    Tissue specificityi

    Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.

    Developmental stagei

    Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up-regulated following malignant transformation in some cell types.

    Gene expression databases

    ArrayExpressiP50895.
    BgeeiP50895.
    CleanExiHS_BCAM.
    GenevestigatoriP50895.

    Organism-specific databases

    HPAiHPA005654.

    Interactioni

    Protein-protein interaction databases

    BioGridi110237. 4 interactions.
    MINTiMINT-5004331.
    STRINGi9606.ENSP00000270233.

    Structurei

    Secondary structure

    1
    628
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi34 – 363
    Beta strandi39 – 446
    Beta strandi49 – 513
    Beta strandi54 – 574
    Beta strandi60 – 6910
    Beta strandi77 – 848
    Beta strandi87 – 926
    Beta strandi110 – 1145
    Helixi117 – 1193
    Beta strandi121 – 1288
    Helixi130 – 1323
    Beta strandi134 – 14512
    Beta strandi151 – 1544
    Beta strandi167 – 17913
    Beta strandi182 – 1876
    Beta strandi190 – 1923
    Beta strandi200 – 21011
    Beta strandi216 – 2249
    Helixi228 – 2325
    Beta strandi234 – 2429
    Helixi244 – 2463
    Beta strandi248 – 2525

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PETX-ray1.70A32-262[»]
    2PF6X-ray2.20A/B32-262[»]
    ProteinModelPortaliP50895.
    SMRiP50895. Positions 32-532.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP50895.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 547516ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini569 – 62860CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei548 – 56821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 142111Ig-like V-type 1Add
    BLAST
    Domaini147 – 257111Ig-like V-type 2Add
    BLAST
    Domaini274 – 35582Ig-like C2-type 1Add
    BLAST
    Domaini363 – 44179Ig-like C2-type 2Add
    BLAST
    Domaini448 – 54194Ig-like C2-type 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni309 – 3124Interaction with laminin alpha5

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150030.
    HOGENOMiHOG000113409.
    InParanoidiP50895.
    KOiK06578.
    OMAiHYPTEHV.
    OrthoDBiEOG7GBFWH.
    PhylomeDBiP50895.
    TreeFamiTF330534.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    SM00408. IGc2. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P50895-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPPDAPAQA RGAPRLLLLA VLLAAHPDAQ AEVRLSVPPL VEVMRGKSVI    50
    LDCTPTGTHD HYMLEWFLTD RSGARPRLAS AEMQGSELQV TMHDTRGRSP 100
    PYQLDSQGRL VLAEAQVGDE RDYVCVVRAG AAGTAEATAR LNVFAKPEAT 150
    EVSPNKGTLS VMEDSAQEIA TCNSRNGNPA PKITWYRNGQ RLEVPVEMNP 200
    EGYMTSRTVR EASGLLSLTS TLYLRLRKDD RDASFHCAAH YSLPEGRHGR 250
    LDSPTFHLTL HYPTEHVQFW VGSPSTPAGW VREGDTVQLL CRGDGSPSPE 300
    YTLFRLQDEQ EEVLNVNLEG NLTLEGVTRG QSGTYGCRVE DYDAADDVQL 350
    SKTLELRVAY LDPLELSEGK VLSLPLNSSA VVNCSVHGLP TPALRWTKDS 400
    TPLGDGPMLS LSSITFDSNG TYVCEASLPT VPVLSRTQNF TLLVQGSPEL 450
    KTAEIEPKAD GSWREGDEVT LICSARGHPD PKLSWSQLGG SPAEPIPGRQ 500
    GWVSSSLTLK VTSALSRDGI SCEASNPHGN KRHVFHFGTV SPQTSQAGVA 550
    VMAVAVSVGL LLLVVAVFYC VRRKGGPCCR QRREKGAPPP GEPGLSHSGS 600
    EQPEQTGLLM GGASGGARGG SGGFGDEC 628
    Length:628
    Mass (Da):67,405
    Last modified:March 7, 2006 - v2
    Checksum:iC88F4F5C640C3F5B
    GO

    Sequence cautioni

    The sequence EAW57297.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti225 – 2262RL → PC in CAA56327. (PubMed:7954395)Curated
    Sequence conflicti355 – 3562EL → DV in CAA56327. (PubMed:7954395)Curated
    Sequence conflicti532 – 5321R → L in ABY27636. 1 PublicationCurated

    Polymorphismi

    BCAM is responsible for the Lutheran blood group system (LU) [MIMi:111200]. Lutheran is a complex blood group system consisting of 19 antigens. Antigens Lu(a) and Lu(b) are defined by a polymorphism at position 77: Lu(a) has His-77 and Lu(b) has Arg-77.
    Inactivating variants in BCAM are responsible for the recessive Lutheran null phenotype Lu(a-b-) of the Lutheran blood group [MIMi:247420]. Autosomal recessive inheritance of the Lutheran null blood group phenotype is extremely rare. There is no obvious associated clinical or hematologic pathology, and all patients have been identified through identification of anti-Lu3 antibodies in their serum.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771R → H Defines the Lu(a) antigen. 1 Publication
    Corresponds to variant rs28399653 [ dbSNP | Ensembl ].
    VAR_021348
    Natural varianti196 – 1961V → I.1 Publication
    Corresponds to variant rs28399654 [ dbSNP | Ensembl ].
    VAR_021349
    Natural varianti204 – 2041M → K.1 Publication
    Corresponds to variant rs28399656 [ dbSNP | Ensembl ].
    VAR_021350
    Natural varianti282 – 2821R → H.1 Publication
    Corresponds to variant rs9967601 [ dbSNP | Ensembl ].
    VAR_021351
    Natural varianti381 – 3811V → I.1 Publication
    Corresponds to variant rs28399626 [ dbSNP | Ensembl ].
    VAR_021352
    Natural varianti451 – 4511K → Q.1 Publication
    Corresponds to variant rs28399630 [ dbSNP | Ensembl ].
    VAR_021353
    Natural varianti539 – 5391T → A.3 Publications
    Corresponds to variant rs1135062 [ dbSNP | Ensembl ].
    VAR_021354
    Natural varianti581 – 5811Q → L.1 Publication
    Corresponds to variant rs28399659 [ dbSNP | Ensembl ].
    VAR_021355

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83425 mRNA. Translation: CAA58449.1.
    AY845133 Genomic DNA. Translation: AAV88096.1.
    AC092306 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57297.1. Sequence problems.
    BC050450 mRNA. Translation: AAH50450.1.
    X80026 mRNA. Translation: CAA56327.1.
    EU307108 Genomic DNA. Translation: ABY27636.1.
    EU307109 Genomic DNA. Translation: ABY27637.1.
    CCDSiCCDS12644.1.
    PIRiI37202.
    I38000.
    RefSeqiNP_001013275.1. NM_001013257.2.
    NP_005572.2. NM_005581.4.
    UniGeneiHs.625725.

    Genome annotation databases

    EnsembliENST00000270233; ENSP00000270233; ENSG00000187244.
    GeneIDi4059.
    KEGGihsa:4059.
    UCSCiuc002ozt.2. human.

    Polymorphism databases

    DMDMi92058724.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    dbRBC/BGMUT

    Blood group antigen gene mutation database

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83425 mRNA. Translation: CAA58449.1 .
    AY845133 Genomic DNA. Translation: AAV88096.1 .
    AC092306 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57297.1 . Sequence problems.
    BC050450 mRNA. Translation: AAH50450.1 .
    X80026 mRNA. Translation: CAA56327.1 .
    EU307108 Genomic DNA. Translation: ABY27636.1 .
    EU307109 Genomic DNA. Translation: ABY27637.1 .
    CCDSi CCDS12644.1.
    PIRi I37202.
    I38000.
    RefSeqi NP_001013275.1. NM_001013257.2.
    NP_005572.2. NM_005581.4.
    UniGenei Hs.625725.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PET X-ray 1.70 A 32-262 [» ]
    2PF6 X-ray 2.20 A/B 32-262 [» ]
    ProteinModelPortali P50895.
    SMRi P50895. Positions 32-532.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110237. 4 interactions.
    MINTi MINT-5004331.
    STRINGi 9606.ENSP00000270233.

    PTM databases

    PhosphoSitei P50895.

    Polymorphism databases

    DMDMi 92058724.

    Proteomic databases

    MaxQBi P50895.
    PaxDbi P50895.
    PRIDEi P50895.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270233 ; ENSP00000270233 ; ENSG00000187244 .
    GeneIDi 4059.
    KEGGi hsa:4059.
    UCSCi uc002ozt.2. human.

    Organism-specific databases

    CTDi 4059.
    GeneCardsi GC19P045312.
    HGNCi HGNC:6722. BCAM.
    HPAi HPA005654.
    MIMi 111200. phenotype.
    247420. phenotype.
    612773. gene.
    neXtProti NX_P50895.
    PharmGKBi PA30484.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150030.
    HOGENOMi HOG000113409.
    InParanoidi P50895.
    KOi K06578.
    OMAi HYPTEHV.
    OrthoDBi EOG7GBFWH.
    PhylomeDBi P50895.
    TreeFami TF330534.

    Miscellaneous databases

    ChiTaRSi BCAM. human.
    EvolutionaryTracei P50895.
    GeneWikii BCAM.
    GenomeRNAii 4059.
    NextBioi 15906.
    PROi P50895.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50895.
    Bgeei P50895.
    CleanExi HS_BCAM.
    Genevestigatori P50895.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    SM00408. IGc2. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver."
      Parsons S.F., Mallinson G., Holmes C.H., Houlihan J.M., Simpson K.L., Mawby W.J., Spurr N.K., Warne D., Barclay A.N., Anstee D.J.
      Proc. Natl. Acad. Sci. U.S.A. 92:5496-5500(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 32-67 AND 182-203, VARIANT ALA-539.
      Tissue: Placenta.
    2. SeattleSNPs variation discovery resource
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-77; ILE-196; LYS-204; HIS-282; ILE-381; GLN-451 AND LEU-581.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily."
      Campbell I.G., Foulkes W.D., Senger G., Trowsdale J., Garin-Chesa P., Rettig W.J.
      Cancer Res. 54:5761-5765(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-588, VARIANT ALA-539.
    7. "Molecular basis of Lub(-) individual among Chinese blood donors in Shanghai area."
      Wang C., Li Q., Guo Z., Yang Y., Zhu Z.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 492-539, VARIANT ALA-539.
    8. "Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms."
      Parsons S.F., Mallinson G., Daniels G.L., Green C.A., Smythe J.S., Anstee D.J.
      Blood 89:4219-4225(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: LU(A)/LU(B) POLYMORPHISM.
    9. "Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism."
      El Nemer W., Rahuel C., Colin Y., Gane P., Cartron J.P., Le Van Kim C.
      Blood 89:4608-4616(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: LU(A)/LU(B) POLYMORPHISM.
    10. "Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin."
      Udani M., Zen Q., Cottman M., Leonard N., Jefferson S., Daymont C., Truskey G., Telen M.J.
      J. Clin. Invest. 101:2550-2558(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-439.
    12. "Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5."
      Gauthier E., Rahuel C., Wautier M.P., El Nemer W., Gane P., Wautier J.L., Cartron J.P., Colin Y., Le Van Kim C.
      J. Biol. Chem. 280:30055-30062(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-596; SER-598 AND SER-621, MUTAGENESIS OF SER-621.
    13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-439.
      Tissue: Plasma.
    14. "Different inactivating mutations in the LU genes of three individuals with the Lutheran-null phenotype."
      Karamatic Crew V., Mallinson G., Green C., Poole J., Uchikawa M., Tani Y., Geisen C., Oldenburg J., Daniels G.
      Transfusion 47:492-498(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN THE LUTHERAN NULL PHENOTYPE.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3."
      Mankelow T.J., Burton N., Stefansdottir F.O., Spring F.A., Parsons S.F., Pedersen J.S., Oliveira C.L., Lammie D., Wess T., Mohandas N., Chasis J.A., Brady R.L., Anstee D.J.
      Blood 110:3398-3406(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 32-262, LAMININ-ALPHA5 BINDING REGION, DISULFIDE BONDS.

    Entry informationi

    Entry nameiBCAM_HUMAN
    AccessioniPrimary (citable) accession number: P50895
    Secondary accession number(s): A8MYF9
    , A9YWT5, A9YWT6, Q86VC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Blood group antigen proteins
      Nomenclature of blood group antigens and list of entries
    2. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    3. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    8. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3