Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L22

Gene

RpL22

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L22
Gene namesi
Name:RpL22
ORF Names:CG7434
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0015288 RpL22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155091 – 29960S ribosomal protein L22Add BLAST299

Proteomic databases

PaxDbiP50887
PRIDEiP50887

Expressioni

Gene expression databases

BgeeiFBgn0015288
GenevisibleiP50887 DM

Interactioni

Protein-protein interaction databases

BioGridi57590, 43 interactors
DIPiDIP-19124N
IntActiP50887, 5 interactors
MINTiP50887
STRINGi7227.FBpp0070143

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CU1-299[»]
ProteinModelPortaliP50887
SMRiP50887
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 31Poly-Ala8
Compositional biasi46 – 50Poly-Ala5
Compositional biasi65 – 70Poly-Ala6
Compositional biasi93 – 98Poly-Ala6
Compositional biasi103 – 112Poly-Ala10
Compositional biasi136 – 152Poly-AlaAdd BLAST17
Compositional biasi185 – 188Poly-Lys4
Compositional biasi292 – 299Asp/Glu-rich (highly acidic)8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3434 Eukaryota
ENOG4111UVJ LUCA
GeneTreeiENSGT00390000003719
InParanoidiP50887
KOiK02891
OMAiTIDCTNI
OrthoDBiEOG091G0POE
PhylomeDBiP50887

Family and domain databases

Gene3Di3.30.1360.210, 1 hit
InterProiView protein in InterPro
IPR002671 Ribosomal_L22e
IPR038526 Ribosomal_L22e_sf
PANTHERiPTHR10064 PTHR10064, 1 hit
PfamiView protein in Pfam
PF01776 Ribosomal_L22e, 1 hit

Sequencei

Sequence statusi: Complete.

P50887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTAKTNKG DTKTAAAKPA EKKAAPAAAA AKGKVEKPKA EAAKPAAAAA
60 70 80 90 100
KNVKKASEAA KDVKAAAAAA KPAAAKPAAA KPAAASKDAG KKAPAAAAPK
110 120 130 140 150
KDAKAAAAPA PAKAAPAKKA ASTPAAAPPA KKAAPAKAAA PAAAAPAPAA
160 170 180 190 200
AAPAVAKPAP KPKAKAAPAP SKVVKKNVLR GKGQKKKKVS LRFTIDCTNI
210 220 230 240 250
AEDSIMDVAD FEKYIKARLK VNGKVNNLGN NVTFERSKLK LIVSSDVHFS
260 270 280 290
KAYLKYLTKK YLKKNSLRDW IRVVANEKDS YELRYFRISS NDDEDDDAE
Length:299
Mass (Da):30,611
Last modified:November 1, 1997 - v2
Checksum:i46A99005610E4EB0
GO

Sequence cautioni

The sequence AAD19341 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242I → T in AAD19341 (PubMed:9931508).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42587 mRNA Translation: AAB17433.1
AF080131 mRNA Translation: AAD19341.1 Different initiation.
AE014298 Genomic DNA Translation: AAF45546.1
AL132792 Genomic DNA Translation: CAB60023.1
AY118961 mRNA Translation: AAM50821.1
BT025837 mRNA Translation: ABF85737.1
RefSeqiNP_477134.1, NM_057786.5
UniGeneiDm.6921

Genome annotation databases

EnsemblMetazoaiFBtr0070148; FBpp0070143; FBgn0015288
GeneIDi31022
KEGGidme:Dmel_CG7434

Similar proteinsi

Entry informationi

Entry nameiRL22_DROME
AccessioniPrimary (citable) accession number: P50887
Secondary accession number(s): Q1EC97, Q9UAN1, Q9V3X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health