P50885 (RL18_TRYB2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L18

Gene names

Name:	RPL18-A
ORF Names:	Tb10.6k15.0410
AND
Name:	RPL18-B
ORF Names:	Tb11.02.1840

Organism

Trypanosoma brucei brucei (strain 927/4 GUTat10.1) [Reference proteome]

Taxonomic identifier

999953 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Trypanozoon › Trypanosoma brucei › Trypanosoma brucei brucei

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ribosomal protein L18e family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	60S ribosomal protein L18		PRO_0000132779

Sequences

	Sequence		Length	Mass (Da)
	P50885 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 350856090EAD0388	FASTA	193	21,874
	10 20 30 40 50 60 MGVDLTGVQK KKRVVRHHTY STNPYIKLLI KLYKFLGKRT NSPFNKLIHK RLLKSRNNRA 70 80 90 100 110 120 PISLSRIAVC MRRRTVWLKK GKKSPIAVIV GDVLDDVRMT RIPALRICAL RFSKSARERI 130 140 150 160 170 180 TGAGGECLTF DQLAMMAPTG KNTMLLRGRK SGRESVKHFG AAGVPGSHAK PHVSSRGKER 190 QRSSKRRHAF RHK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cloning and sequencing of a ribosomal L18 protein from an evolutionary divergent eukaryote, Trypanosoma brucei." Coulter L.J., Hide G. Biochim. Biophys. Acta 1309:69-72(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genome of the African trypanosome Trypanosoma brucei." Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M. , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A. Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 927/4 GUTat10.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U47286 mRNA. Translation: AAC47428.1.
CM000208 Genomic DNA. Translation: EAN78382.1.
CH464491 Genomic DNA. Translation: EAN79394.1.

RefSeq

XP_823210.1. XM_818117.1.
XP_828506.1. XM_823413.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3ZF7	electron microscopy	5.57	I	1-193	[»]

ProteinModelPortal

P50885.

ModBase

Search...

Protein-protein interaction databases

STRING

5691.Tb11.02.1840.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

EAN78382; EAN78382; Tb10.6k15.0410.
EAN79394; EAN79394; Tb11.02.1840.

GeneID

3661727.
3664868.

KEGG

tbr:Tb10.6k15.0410.
tbr:Tb11.02.1840.

Organism-specific databases

EuPathDB

TriTrypDB:Tb11.02.1840.
TriTrypDB:Tb427.10.9880.
TriTrypDB:Tb427tmp.02.1840.
TriTrypDB:Tb927.10.9880.

Phylogenomic databases

eggNOG

COG1727.

HOGENOM

HOG000213425.

KO

K02883.

OMA

FMEGKEN.

ProtClustDB

PTZ00195.

Family and domain databases

InterPro

IPR000039. Ribosomal_L18e.
IPR021131. Ribosomal_L18e/L15P.
IPR021132. Ribosomal_L18e_CS.
[Graphical view]

PANTHER

PTHR10934. PTHR10934. 1 hit.

Pfam

PF00828. Ribosomal_L18e. 1 hit.
[Graphical view]

SUPFAM

SSF52080. Ribosomal_L18e/L15. 1 hit.

PROSITE

PS01106. RIBOSOMAL_L18E. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

RL18_TRYB2

Accession

Primary (citable) accession number: P50885
Secondary accession number(s): Q385Y7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)