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Protein

60S ribosomal protein L4

Gene

Rpl4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 5S rRNA binding Source: RGD
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • brain development Source: RGD
  • brainstem development Source: RGD
  • cell differentiation Source: RGD
  • cellular response to organonitrogen compound Source: RGD
  • cytoplasmic translation Source: GO_Central
  • positive regulation of axon extension Source: RGD
  • positive regulation of axonogenesis Source: RGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L4
Alternative name(s):
60S ribosomal protein L1
Gene namesi
Name:Rpl4
Synonyms:Rpl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619824 Rpl4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001293532 – 42160S ribosomal protein L4Add BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei14N6-acetyllysineBy similarity1
Modified residuei97Omega-N-methylarginineBy similarity1
Modified residuei106N6-acetyllysineBy similarity1
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei259N6-acetyllysineBy similarity1
Modified residuei266PhosphothreonineBy similarity1
Modified residuei290PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei300CitrullineBy similarity1
Cross-linki327Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei333N6-acetyllysineBy similarity1
Modified residuei353N6-acetyllysineBy similarity1
Modified residuei364N6-acetyllysine; alternateBy similarity1
Cross-linki364Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Modified residuei365PhosphoserineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP50878
PRIDEiP50878

PTM databases

iPTMnetiP50878
PhosphoSitePlusiP50878

Interactioni

Subunit structurei

May bind IPO9 with low affinity (By similarity). Interacts with RBM3.By similarity1 Publication

Protein-protein interaction databases

BioGridi249017, 4 interactors
IntActiP50878, 1 interactor
STRINGi10116.ENSRNOP00000013462

Structurei

3D structure databases

ProteinModelPortaliP50878
SMRiP50878
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi307 – 421Lys-richAdd BLAST115

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1475 Eukaryota
COG0088 LUCA
HOGENOMiHOG000107331
HOVERGENiHBG001453
InParanoidiP50878
KOiK02930
PhylomeDBiP50878

Family and domain databases

Gene3Di3.40.1370.10, 1 hit
InterProiView protein in InterPro
IPR025755 Ribos_L4_C_dom
IPR002136 Ribosomal_L4/L1e
IPR013000 Ribosomal_L4/L1e_euk/arc_CS
IPR023574 Ribosomal_L4_dom_sf
PfamiView protein in Pfam
PF14374 Ribos_L4_asso_C, 1 hit
PF00573 Ribosomal_L4, 1 hit
SUPFAMiSSF52166 SSF52166, 1 hit
PROSITEiView protein in PROSITE
PS00939 RIBOSOMAL_L1E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ
60 70 80 90 100
PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR
110 120 130 140 150
MFAPTKTWRR WHRRVNTTQK RYAICSALAA SALPALVMSK GHCVEEVPEL
160 170 180 190 200
PLVVEDKVES YKKTKEAVQL LKKLKAWNDI KKVYASQRMR AGKGKMRNRR
210 220 230 240 250
RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL APGGHVGRFC
260 270 280 290 300
IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMMNTDLS RILKSPEIQR
310 320 330 340 350
ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKLR
360 370 380 390 400
VKKLEAAAAA LAAKSEKIVP EKGAGDKKPA VGKKGKKPVD AKKLKKPAGK
410 420
KVVTKKPAEK KPTTEEKKSA A
Length:421
Mass (Da):47,257
Last modified:January 23, 2007 - v3
Checksum:i08C82C1D7A49AAC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82180 mRNA Translation: CAA57671.1
PIRiJC4277
RefSeqiNP_071955.1, NM_022510.1
UniGeneiRn.1133
Rn.178164

Genome annotation databases

GeneIDi64302
KEGGirno:64302
UCSCiRGD:619824 rat

Similar proteinsi

Entry informationi

Entry nameiRL4_RAT
AccessioniPrimary (citable) accession number: P50878
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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