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Protein

Serine/threonine-protein kinase MRK1

Gene

MRK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei193ATPPROSITE-ProRule annotation1
Active sitei289Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi170 – 178ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • cellular response to heat Source: SGD
  • cellular response to salt stress Source: SGD
  • protein phosphorylation Source: SGD
  • regulation of protein catabolic process Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29489-MONOMER
BRENDAi2.7.11.26 984
ReactomeiR-SCE-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase MRK1 (EC:2.7.11.1)
Gene namesi
Name:MRK1
Ordered Locus Names:YDL079C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL079C
SGDiS000002237 MRK1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863991 – 501Serine/threonine-protein kinase MRK1Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP50873
PaxDbiP50873
PRIDEiP50873

PTM databases

iPTMnetiP50873

Interactioni

Protein-protein interaction databases

BioGridi3198290 interactors.
IntActiP50873 10 interactors.
MINTiP50873
STRINGi4932.YDL079C

Structurei

3D structure databases

ProteinModelPortaliP50873
SMRiP50873
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 447Protein kinasePROSITE-ProRule annotationAdd BLAST284

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00520000055635
HOGENOMiHOG000233017
InParanoidiP50873
KOiK08282
OrthoDBiEOG092C1O26

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P50873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDVLRSLVR KISFNNSDNL QLKHKTSIQS NTALEKKKRK PDTIKKVSDV
60 70 80 90 100
QVHHTVPNFN NSSEYINDIE NLIISKLIDG GKEGIAVDHI EHANISDSKT
110 120 130 140 150
DGKVANKHEN ISSKLSKEKV EKMINFDYRY IKTKERTIHK RVYKHDRKTD
160 170 180 190 200
VDRKNHGGTI DISYPTTEVV GHGSFGVVVT TVIIETNQKV AIKKVLQDRR
210 220 230 240 250
YKNRELETMK MLCHPNTVGL QYYFYEKDEE DEVYLNLVLD YMPQSLYQRL
260 270 280 290 300
RHFVNLKMQM PRVEIKFYAY QLFKALNYLH NVPRICHRDI KPQNLLVDPT
310 320 330 340 350
TFSFKICDFG SAKCLKPDQP NVSYICSRYY RAPELMFGAT NYSNQVDVWS
360 370 380 390 400
SACVIAELLL GKPLFSGESG IDQLVEIIKI MGIPTKDEIS GMNPNYEDHV
410 420 430 440 450
FPNIKPITLA EIFKAEDPDT LDLLTKTLKY HPCERLVPLQ CLLSSYFDET
460 470 480 490 500
KRCDTDTYVK AQNLRIFDFD VETELGHVPL VERPAIEERL KHFVSAPSSS

L
Length:501
Mass (Da):57,819
Last modified:August 31, 2004 - v2
Checksum:iB0C938AF8E63E5AA
GO

Sequence cautioni

The sequence AAA74429 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74127 Genomic DNA Translation: CAA98645.1
U22348 Genomic DNA Translation: AAA74429.1 Sequence problems.
BK006938 Genomic DNA Translation: DAA11780.1
PIRiS67615
RefSeqiNP_010204.1, NM_001180138.1

Genome annotation databases

EnsemblFungiiYDL079C; YDL079C; YDL079C
GeneIDi851480
KEGGisce:YDL079C

Similar proteinsi

Entry informationi

Entry nameiMRK1_YEAST
AccessioniPrimary (citable) accession number: P50873
Secondary accession number(s): D6VRS0, Q07470
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 31, 2004
Last modified: March 28, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome