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Protein

Serine/threonine-protein kinase MRK1

Gene

MRK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei193 – 1931ATPPROSITE-ProRule annotation
Active sitei289 – 2891Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi170 – 1789ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • cellular response to heat Source: SGD
  • cellular response to salt stress Source: SGD
  • protein phosphorylation Source: SGD
  • regulation of protein catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29489-MONOMER.
BRENDAi2.7.11.26. 984.
ReactomeiR-SCE-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase MRK1 (EC:2.7.11.1)
Gene namesi
Name:MRK1
Ordered Locus Names:YDL079C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL079C.
SGDiS000002237. MRK1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Serine/threonine-protein kinase MRK1PRO_0000086399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP50873.
PRIDEiP50873.

PTM databases

iPTMnetiP50873.

Interactioni

Protein-protein interaction databases

BioGridi31982. 44 interactions.
IntActiP50873. 6 interactions.
MINTiMINT-6673660.

Structurei

3D structure databases

ProteinModelPortaliP50873.
SMRiP50873. Positions 160-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 447284Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00520000055635.
HOGENOMiHOG000233017.
InParanoidiP50873.
KOiK08282.
OrthoDBiEOG092C1O26.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDVLRSLVR KISFNNSDNL QLKHKTSIQS NTALEKKKRK PDTIKKVSDV
60 70 80 90 100
QVHHTVPNFN NSSEYINDIE NLIISKLIDG GKEGIAVDHI EHANISDSKT
110 120 130 140 150
DGKVANKHEN ISSKLSKEKV EKMINFDYRY IKTKERTIHK RVYKHDRKTD
160 170 180 190 200
VDRKNHGGTI DISYPTTEVV GHGSFGVVVT TVIIETNQKV AIKKVLQDRR
210 220 230 240 250
YKNRELETMK MLCHPNTVGL QYYFYEKDEE DEVYLNLVLD YMPQSLYQRL
260 270 280 290 300
RHFVNLKMQM PRVEIKFYAY QLFKALNYLH NVPRICHRDI KPQNLLVDPT
310 320 330 340 350
TFSFKICDFG SAKCLKPDQP NVSYICSRYY RAPELMFGAT NYSNQVDVWS
360 370 380 390 400
SACVIAELLL GKPLFSGESG IDQLVEIIKI MGIPTKDEIS GMNPNYEDHV
410 420 430 440 450
FPNIKPITLA EIFKAEDPDT LDLLTKTLKY HPCERLVPLQ CLLSSYFDET
460 470 480 490 500
KRCDTDTYVK AQNLRIFDFD VETELGHVPL VERPAIEERL KHFVSAPSSS

L
Length:501
Mass (Da):57,819
Last modified:August 31, 2004 - v2
Checksum:iB0C938AF8E63E5AA
GO

Sequence cautioni

The sequence AAA74429 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74127 Genomic DNA. Translation: CAA98645.1.
U22348 Genomic DNA. Translation: AAA74429.1. Sequence problems.
BK006938 Genomic DNA. Translation: DAA11780.1.
PIRiS67615.
RefSeqiNP_010204.1. NM_001180138.1.

Genome annotation databases

EnsemblFungiiYDL079C; YDL079C; YDL079C.
GeneIDi851480.
KEGGisce:YDL079C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74127 Genomic DNA. Translation: CAA98645.1.
U22348 Genomic DNA. Translation: AAA74429.1. Sequence problems.
BK006938 Genomic DNA. Translation: DAA11780.1.
PIRiS67615.
RefSeqiNP_010204.1. NM_001180138.1.

3D structure databases

ProteinModelPortaliP50873.
SMRiP50873. Positions 160-491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31982. 44 interactions.
IntActiP50873. 6 interactions.
MINTiMINT-6673660.

PTM databases

iPTMnetiP50873.

Proteomic databases

MaxQBiP50873.
PRIDEiP50873.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL079C; YDL079C; YDL079C.
GeneIDi851480.
KEGGisce:YDL079C.

Organism-specific databases

EuPathDBiFungiDB:YDL079C.
SGDiS000002237. MRK1.

Phylogenomic databases

GeneTreeiENSGT00520000055635.
HOGENOMiHOG000233017.
InParanoidiP50873.
KOiK08282.
OrthoDBiEOG092C1O26.

Enzyme and pathway databases

BioCyciYEAST:G3O-29489-MONOMER.
BRENDAi2.7.11.26. 984.
ReactomeiR-SCE-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

PROiP50873.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRK1_YEAST
AccessioniPrimary (citable) accession number: P50873
Secondary accession number(s): D6VRS0, Q07470
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 31, 2004
Last modified: September 7, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.