P50872 (TRPE_AZOBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase
EC=4.1.3.27

Including the following 1 domains:

1. Glutamine amidotransferase

Gene names

Name:

trpE(G)

Organism

Azospirillum brasilense

Taxonomic identifier

192 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Azospirillum

Protein attributes

Sequence length	732 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Sequence similarities	Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Lyase
Gene Ontology (GO)
Biological process	glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 732	732	Anthranilate synthase		PRO_0000056867
Regions
	Domain	533 – 728	196	Glutamine amidotransferase type-1
Sites
	Active site	610	1	For GATase activity By similarity
	Active site	699	1	For GATase activity By similarity
	Active site	701	1	For GATase activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50872 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 4195A53D381B4B7A	FASTA	732	78,042
	10 20 30 40 50 60 MYPADLLASP DLLEPLRFQT RGGVTVTRRA TALDPRTALD PVIDALDRRR GLLLSSGVEA 70 80 90 100 110 120 PGRYRRHALG FTDPAVALTA RGRTLRIDAL NGRGQVLLPA VAEALRGLEA LAGLEEAPSR 130 140 150 160 170 180 VTASSASPAP LPGEERSRQP SVFSVLRAVL DLFAAPDDPL LGLYGAFAYD LAFQFEPIRQ 190 200 210 220 230 240 RLERPDDQRD LLLYLPDRLV ALDPIAGLAR LVAYEFITAA GSTEGLECGG RDHPYRPDTN 250 260 270 280 290 300 AEAGCDHAPG DYQRVVESAK AAFRRGDLFE VVPGQTFAEP CADAPSSVFR RLRAANPAPY 310 320 330 340 350 360 EAFVNLGRGE FLVAASPEMY VRVAGGRVET CPISGTVARG ADALGDAAQV LRLLTSAKDA 370 380 390 400 410 420 AELTMCTDVD RNDKARVCEP GSVRVIGRRM IELYSRLIHT VDHVEGRLRS GMDALDAFLT 430 440 450 460 470 480 HSWAVTVTGA PKRWAMQFLE DTEQSPRRWY GGAFGRLGFD GGMDTGLTLR TIRMAEGVAY 490 500 510 520 530 540 VRAGATLLSD SDPDAEDAEC RLKAAAFRDA IRGTAAGAAP TLPAAPRGGE GRRVLLVDHD 550 560 570 580 590 600 DSFVHTLADY LRQTGASVTT LRHSHARAAL AERRPDLVVL SPGPGRPADF DVAGTIDAAL 610 620 630 640 650 660 ALGLPVFGVC LGLQGMVERF GGALDVLPEP VHGKATEVRV LGGALFAGLP ERLTVGRYHS 670 680 690 700 710 720 LVARRDRLPA DLTVTAETAD GLVMAVEHRR LPLAAVQFHP ESILSLDGGA GLALLGNVMD 730 RLAAGALTDA AA

References

[1]	"Isolation and characterization of the Azospirillum brasilense trpE(G) gene, encoding anthranilate synthase." de Troch P., Dosselaere F., Keijers V., de Wilde P., Vanderleyden J. Curr. Microbiol. 34:27-32(1997) [PubMed: 8939798] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 29145 / Sp7 / DSM 1690 / IMET 11303.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U44127 Genomic DNA. Translation: AAC45141.1.
3D structure databases
ProteinModelPortal	P50872.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR010112. Anthranilate_synth_clad3. IPR015890. Chorismate-bd_C. IPR017926. GATASE_1. IPR006221. TrpG_papA. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. PF00117. GATase. 1 hit. [Graphical view]
PIRSF	PIRSF036934. TrpE-G. 1 hit.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR01815. TrpE-clade3. 1 hit. TIGR00566. TrpG_papA. 1 hit.
PROSITE	PS51273. GATASE_TYPE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPE_AZOBR

Accession

Primary (citable) accession number: P50872

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program