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Protein

Streptogramin A acetyltransferase

Gene

vatD

Organism
Enterococcus faecium (Streptococcus faecium)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei821

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Streptogramin A acetyltransferase (EC:2.3.1.-)
Alternative name(s):
Virginiamycin acetyltransferase D
Short name:
Vat(D)
Gene namesi
Name:vatD
Synonyms:satA
OrganismiEnterococcus faecium (Streptococcus faecium)
Taxonomic identifieri1352 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82H → A: 105-fold decrease in activity. 1 Publication1

Chemistry databases

DrugBankiDB01764. Dalfopristin.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686631 – 209Streptogramin A acetyltransferaseAdd BLAST209

Interactioni

Subunit structurei

Homohexamer.

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 13Combined sources3
Beta strandi16 – 19Combined sources4
Helixi20 – 24Combined sources5
Beta strandi30 – 32Combined sources3
Beta strandi37 – 39Combined sources3
Beta strandi41 – 43Combined sources3
Helixi46 – 49Combined sources4
Beta strandi50 – 52Combined sources3
Helixi55 – 57Combined sources3
Beta strandi61 – 63Combined sources3
Beta strandi74 – 76Combined sources3
Helixi78 – 80Combined sources3
Helixi91 – 94Combined sources4
Helixi98 – 101Combined sources4
Helixi105 – 107Combined sources3
Beta strandi114 – 116Combined sources3
Beta strandi154 – 157Combined sources4
Turni158 – 161Combined sources4
Beta strandi162 – 168Combined sources7
Helixi170 – 179Combined sources10
Helixi181 – 183Combined sources3
Helixi186 – 191Combined sources6
Helixi193 – 198Combined sources6
Helixi200 – 202Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KHRX-ray2.80A/B/C/D/E/F1-209[»]
1KK4X-ray2.70A/B/C/D/E/F1-209[»]
1KK5X-ray2.70A/B/C/D/E/F1-209[»]
1KK6X-ray2.50A/B/C1-209[»]
1MR7X-ray1.80A/B/C/X/Y/Z1-209[»]
1MR9X-ray3.00A/B/C/X/Y/Z1-209[»]
1MRLX-ray2.80A/B/C1-209[»]
3DHOX-ray1.80A/B/C/D/E/F1-209[»]
ProteinModelPortaliP50870.
SMRiP50870.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50870.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK18234.

Family and domain databases

InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPNPMKMYP IEGNKSVQFI KPILEKLENV EVGEYSYYDS KNGETFDKQI
60 70 80 90 100
LYHYPILNDK LKIGKFCSIG PGVTIIMNGA NHRMDGSTYP FNLFGNGWEK
110 120 130 140 150
HMPKLDQLPI KGDTIIGNDV WIGKDVVIMP GVKIGDGAIV AANSVVVKDI
160 170 180 190 200
APYMLAGGNP ANEIKQRFDQ DTINQLLDIK WWNWPIDIIN ENIDKILDNS

IIREVIWKK
Length:209
Mass (Da):23,649
Last modified:October 1, 1996 - v1
Checksum:i75F52F1DD0C135C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12033 Genomic DNA. Translation: AAA24783.1.
RefSeqiWP_002295712.1. NG_048540.1.

Genome annotation databases

KEGGiag:AAA24783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12033 Genomic DNA. Translation: AAA24783.1.
RefSeqiWP_002295712.1. NG_048540.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KHRX-ray2.80A/B/C/D/E/F1-209[»]
1KK4X-ray2.70A/B/C/D/E/F1-209[»]
1KK5X-ray2.70A/B/C/D/E/F1-209[»]
1KK6X-ray2.50A/B/C1-209[»]
1MR7X-ray1.80A/B/C/X/Y/Z1-209[»]
1MR9X-ray3.00A/B/C/X/Y/Z1-209[»]
1MRLX-ray2.80A/B/C1-209[»]
3DHOX-ray1.80A/B/C/D/E/F1-209[»]
ProteinModelPortaliP50870.
SMRiP50870.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB01764. Dalfopristin.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAA24783.

Phylogenomic databases

KOiK18234.

Miscellaneous databases

EvolutionaryTraceiP50870.

Family and domain databases

InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVATD_ENTFC
AccessioniPrimary (citable) accession number: P50870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.