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Protein

Streptogramin A acetyltransferase

Gene

vatD

Organism
Enterococcus faecium (Streptococcus faecium)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei821

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Streptogramin A acetyltransferase (EC:2.3.1.-)
Alternative name(s):
Virginiamycin acetyltransferase D
Short name:
Vat(D)
Gene namesi
Name:vatD
Synonyms:satA
OrganismiEnterococcus faecium (Streptococcus faecium)
Taxonomic identifieri1352 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi82H → A: 105-fold decrease in activity. 1 Publication1

Chemistry databases

DrugBankiDB01992 Coenzyme A
DB01764 Dalfopristin
DB01669 Virginiamycin M1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686631 – 209Streptogramin A acetyltransferaseAdd BLAST209

Interactioni

Subunit structurei

Homohexamer.

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 13Combined sources3
Beta strandi16 – 19Combined sources4
Helixi20 – 24Combined sources5
Beta strandi30 – 32Combined sources3
Beta strandi37 – 39Combined sources3
Beta strandi41 – 43Combined sources3
Helixi46 – 49Combined sources4
Beta strandi50 – 52Combined sources3
Helixi55 – 57Combined sources3
Beta strandi61 – 63Combined sources3
Beta strandi74 – 76Combined sources3
Helixi78 – 80Combined sources3
Helixi91 – 94Combined sources4
Helixi98 – 101Combined sources4
Helixi105 – 107Combined sources3
Beta strandi114 – 116Combined sources3
Beta strandi154 – 157Combined sources4
Turni158 – 161Combined sources4
Beta strandi162 – 168Combined sources7
Helixi170 – 179Combined sources10
Helixi181 – 183Combined sources3
Helixi186 – 191Combined sources6
Helixi193 – 198Combined sources6
Helixi200 – 202Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KHRX-ray2.80A/B/C/D/E/F1-209[»]
1KK4X-ray2.70A/B/C/D/E/F1-209[»]
1KK5X-ray2.70A/B/C/D/E/F1-209[»]
1KK6X-ray2.50A/B/C1-209[»]
1MR7X-ray1.80A/B/C/X/Y/Z1-209[»]
1MR9X-ray3.00A/B/C/X/Y/Z1-209[»]
1MRLX-ray2.80A/B/C1-209[»]
3DHOX-ray1.80A/B/C/D/E/F1-209[»]
ProteinModelPortaliP50870
SMRiP50870
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50870

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK18234

Family and domain databases

InterProiView protein in InterPro
IPR001451 Hexapep
IPR018357 Hexapep_transf_CS
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 1 hit

Sequencei

Sequence statusi: Complete.

P50870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPNPMKMYP IEGNKSVQFI KPILEKLENV EVGEYSYYDS KNGETFDKQI
60 70 80 90 100
LYHYPILNDK LKIGKFCSIG PGVTIIMNGA NHRMDGSTYP FNLFGNGWEK
110 120 130 140 150
HMPKLDQLPI KGDTIIGNDV WIGKDVVIMP GVKIGDGAIV AANSVVVKDI
160 170 180 190 200
APYMLAGGNP ANEIKQRFDQ DTINQLLDIK WWNWPIDIIN ENIDKILDNS

IIREVIWKK
Length:209
Mass (Da):23,649
Last modified:October 1, 1996 - v1
Checksum:i75F52F1DD0C135C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12033 Genomic DNA Translation: AAA24783.1
RefSeqiWP_002295712.1, NZ_PTVH01000201.1

Genome annotation databases

KEGGiag:AAA24783

Similar proteinsi

Entry informationi

Entry nameiVATD_ENTFC
AccessioniPrimary (citable) accession number: P50870
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

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