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P50857

- TRPF_CANGA

UniProt

P50857 - TRPF_CANGA

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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
Ordered Locus Names:CAGL0C04092g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome C

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154331Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP50857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

HOGENOMiHOG000161598.
InParanoidiP50857.
KOiK01817.
OMAiKLINSPP.
OrthoDBiEOG76MKM7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

P50857-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFDSLLDKN DKLVKVCGIQ TVEAAETALQ AGADLIGIIC VPNRKRTIES
60 70 80 90 100
AVAREISKLI HKSGTTKLVG VFRNQSVEDV HRLSEEYDLD IIQLHGDESW
110 120 130 140 150
PEYYNVIKKP IIKRVIFPRD VDVVTQVCQR KPLVCLPLFD SEAGGTGEKL
160 170 180 190 200
DWSSISSWAS EQNNVFYILA GGLTAENVME AVGLPGVIGV DVSGGVETDG
210
VKDNDKIIKY VQNAKKQ
Length:217
Mass (Da):23,830
Last modified:August 31, 2004 - v2
Checksum:iBF4AD8B89AF81184
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1493GEK → VKE in AAC49146. (PubMed:8522176)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31471 Genomic DNA. Translation: AAC49146.1.
AF520060 Genomic DNA. Translation: AAM74212.1.
CR380949 Genomic DNA. Translation: CAG58259.1.
PIRiJC4380.
RefSeqiXP_445353.1. XM_445353.1.

Genome annotation databases

GeneIDi2886909.
KEGGicgr:CAGL0C04092g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31471 Genomic DNA. Translation: AAC49146.1 .
AF520060 Genomic DNA. Translation: AAM74212.1 .
CR380949 Genomic DNA. Translation: CAG58259.1 .
PIRi JC4380.
RefSeqi XP_445353.1. XM_445353.1.

3D structure databases

ProteinModelPortali P50857.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2886909.
KEGGi cgr:CAGL0C04092g.

Phylogenomic databases

HOGENOMi HOG000161598.
InParanoidi P50857.
KOi K01817.
OMAi KLINSPP.
OrthoDBi EOG76MKM7.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the Candida glabrata TRP1 and HIS3 genes, and construction of their disruptant strains by sequential integrative transformation."
    Kitada K., Yamaguchi E., Arisawa M.
    Gene 165:203-206(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.
  2. "Gene order evolution and paleopolyploidy in hemiascomycete yeasts."
    Wong S., Butler G., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 99:9272-9277(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.
  3. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Entry informationi

Entry nameiTRPF_CANGA
AccessioniPrimary (citable) accession number: P50857
Secondary accession number(s): Q8NJS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 31, 2004
Last modified: October 29, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3