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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. N-(5'-phosphoribosyl)anthranilate isomerase (TRP1)
  4. no protein annotated in this organism
  5. Tryptophan synthase (TRP5)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • cellular amino acid biosynthetic process Source: UniProtKB-KW
  • tryptophan biosynthetic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
Ordered Locus Names:CAGL0C04092g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome C

Organism-specific databases

CGDiCAL0127496. TRP1.
EuPathDBiFungiDB:CAGL0C04092g.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001543311 – 217N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST217

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_445353.1.

Structurei

3D structure databases

ProteinModelPortaliP50857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiKOG4202. Eukaryota.
COG0135. LUCA.
HOGENOMiHOG000161598.
InParanoidiP50857.
KOiK01817.
OMAiLHGDESW.
OrthoDBiEOG092C59PB.

Family and domain databases

CDDicd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

P50857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFDSLLDKN DKLVKVCGIQ TVEAAETALQ AGADLIGIIC VPNRKRTIES
60 70 80 90 100
AVAREISKLI HKSGTTKLVG VFRNQSVEDV HRLSEEYDLD IIQLHGDESW
110 120 130 140 150
PEYYNVIKKP IIKRVIFPRD VDVVTQVCQR KPLVCLPLFD SEAGGTGEKL
160 170 180 190 200
DWSSISSWAS EQNNVFYILA GGLTAENVME AVGLPGVIGV DVSGGVETDG
210
VKDNDKIIKY VQNAKKQ
Length:217
Mass (Da):23,830
Last modified:August 31, 2004 - v2
Checksum:iBF4AD8B89AF81184
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147 – 149GEK → VKE in AAC49146 (PubMed:8522176).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31471 Genomic DNA. Translation: AAC49146.1.
AF520060 Genomic DNA. Translation: AAM74212.1.
CR380949 Genomic DNA. Translation: CAG58259.1.
PIRiJC4380.
RefSeqiXP_445353.1. XM_445353.1.

Genome annotation databases

EnsemblFungiiCAG58259; CAG58259; CAGL0C04092g.
GeneIDi2886909.
KEGGicgr:CAGL0C04092g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31471 Genomic DNA. Translation: AAC49146.1.
AF520060 Genomic DNA. Translation: AAM74212.1.
CR380949 Genomic DNA. Translation: CAG58259.1.
PIRiJC4380.
RefSeqiXP_445353.1. XM_445353.1.

3D structure databases

ProteinModelPortaliP50857.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_445353.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG58259; CAG58259; CAGL0C04092g.
GeneIDi2886909.
KEGGicgr:CAGL0C04092g.

Organism-specific databases

CGDiCAL0127496. TRP1.
EuPathDBiFungiDB:CAGL0C04092g.

Phylogenomic databases

eggNOGiKOG4202. Eukaryota.
COG0135. LUCA.
HOGENOMiHOG000161598.
InParanoidiP50857.
KOiK01817.
OMAiLHGDESW.
OrthoDBiEOG092C59PB.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Family and domain databases

CDDicd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPF_CANGA
AccessioniPrimary (citable) accession number: P50857
Secondary accession number(s): Q8NJS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 31, 2004
Last modified: October 5, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.