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Protein

KHG/KDPG aldolase

Gene

kdgA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Pathwayi: 2-dehydro-3-deoxy-D-gluconate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 2-dehydro-3-deoxygluconokinase (kdgK)
  2. KHG/KDPG aldolase (kdgA)
This subpathway is part of the pathway 2-dehydro-3-deoxy-D-gluconate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate, the pathway 2-dehydro-3-deoxy-D-gluconate degradation and in Carbohydrate acid metabolism.

Pathwayi: glyoxylate and dicarboxylate metabolism

This protein is involved in the pathway glyoxylate and dicarboxylate metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway glyoxylate and dicarboxylate metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43By similarity1
Active sitei47By similarity1
Active sitei130Schiff-base intermediate with KHG or pyruvateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Multifunctional enzyme
LigandSchiff base

Enzyme and pathway databases

BioCyciBSUB:BSU22100-MONOMER
UniPathwayiUPA00227
UPA00856; UER00829

Names & Taxonomyi

Protein namesi
Recommended name:
KHG/KDPG aldolase
Including the following 2 domains:
4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
Alternative name(s):
2-keto-4-hydroxyglutarate aldolase
Short name:
KHG-aldolase
2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
Alternative name(s):
2-keto-3-deoxy-6-phosphogluconate aldolase
Short name:
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene namesi
Name:kdgA
Ordered Locus Names:BSU22100
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002010361 – 196KHG/KDPG aldolaseAdd BLAST196

Proteomic databases

PaxDbiP50846
PRIDEiP50846

Expressioni

Inductioni

Induced by galacturonate and negatively regulated by the KdgR repressor. Is subject to catabolite repression by glucose involving the ccpA gene.1 Publication

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100012166

Structurei

3D structure databases

ProteinModelPortaliP50846
SMRiP50846
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KHG/KDPG aldolase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHU Bacteria
COG0800 LUCA
HOGENOMiHOG000233113
InParanoidiP50846
KOiK01625
OMAiTGLKFFP
PhylomeDBiP50846

Family and domain databases

CDDicd00452 KDPG_aldolase, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR000887 Aldlse_KDPG_KHG
IPR013785 Aldolase_TIM
IPR031338 KDPG/KHG_AS_2
PANTHERiPTHR30246 PTHR30246, 1 hit
PfamiView protein in Pfam
PF01081 Aldolase, 1 hit
TIGRFAMsiTIGR01182 eda, 1 hit
PROSITEiView protein in PROSITE
PS00160 ALDOLASE_KDPG_KHG_2, 1 hit

Sequencei

Sequence statusi: Complete.

P50846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKVVENRL KEAKLIAVIR SKDKQEACQQ IESLLDKGIR AVEVTYTTPG
60 70 80 90 100
ASDIIESFRN REDILIGAGT VISAQQAGEA AKAGAQFIVS PGFSADLAEH
110 120 130 140 150
LSFVKTHYIP GVLTPSEIME ALTFGFTTLK LFPSGVFGIP FMKNLAGPFP
160 170 180 190
QVTFIPTGGI HPSEVPDWLR AGAGAVGVGS QLGSCSKEDL QAVFQV
Length:196
Mass (Da):20,865
Last modified:October 1, 1996 - v1
Checksum:iEB0B597FD1102CC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47838 Genomic DNA Translation: AAB38480.1
AL009126 Genomic DNA Translation: CAB14127.1
PIRiH69647
RefSeqiNP_390092.1, NC_000964.3
WP_003230732.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14127; CAB14127; BSU22100
GeneIDi939066
KEGGibsu:BSU22100
PATRICifig|224308.179.peg.2414

Entry informationi

Entry nameiALKH_BACSU
AccessioniPrimary (citable) accession number: P50846
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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