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P50828

- HEMO_PIG

UniProt

P50828 - HEMO_PIG

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Protein
Hemopexin
Gene
HPX
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi151 – 1511Iron (heme 1 axial ligand) By similarity
Metal bindingi237 – 2371Iron (heme 2 axial ligand) By similarity
Metal bindingi286 – 2861Iron (heme 2 axial ligand) By similarity

GO - Molecular functioni

  1. hyalurononglucosaminidase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemopexin
Alternative name(s):
Hyaluronidase (EC:3.2.1.35)
Gene namesi
Name:HPX
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 Publication
Add
BLAST
Chaini29 – 459431Hemopexin
PRO_0000021408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi52 ↔ 232 By similarity
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi150 ↔ 155 By similarity
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi189 ↔ 201 By similarity
Glycosylationi241 – 2411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi250 ↔ 453 By similarity
Disulfide bondi359 ↔ 401 By similarity
Disulfide bondi411 ↔ 428 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP50828.
PRIDEiP50828.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000015556.

Structurei

3D structure databases

ProteinModelPortaliP50828.
SMRiP50828. Positions 50-453.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati55 – 9541Hemopexin 1
Add
BLAST
Repeati96 – 14045Hemopexin 2
Add
BLAST
Repeati141 – 18545Hemopexin 3
Add
BLAST
Repeati186 – 23247Hemopexin 4
Add
BLAST
Repeati252 – 29746Hemopexin 5
Add
BLAST
Repeati298 – 34548Hemopexin 6
Add
BLAST
Repeati350 – 38940Hemopexin 7
Add
BLAST
Repeati393 – 44351Hemopexin 8
Add
BLAST

Sequence similaritiesi

Belongs to the hemopexin family.
Contains 8 hemopexin repeats.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG251805.
HOGENOMiHOG000112887.
HOVERGENiHBG005956.

Family and domain databases

Gene3Di2.110.10.10. 2 hits.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR016358. Hemopexin_chordata.
IPR018486. Hemopexin_CS.
[Graphical view]
PfamiPF00045. Hemopexin. 3 hits.
[Graphical view]
PIRSFiPIRSF002551. Hemopexin_chordata. 1 hit.
SMARTiSM00120. HX. 5 hits.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 2 hits.
PROSITEiPS00024. HEMOPEXIN. 2 hits.
PS51642. HEMOPEXIN_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50828-1 [UniParc]FASTAAdd to Basket

« Hide

MARALGTVEA PWLLGLCCSL AIAHPLSLTA GPKHGAEGRN ESKPDPDVTE    50
RCSDGWGFDA STLDEHGAML FFKGPSVWAG QNWTRGLISE RWKNAPSSVD 100
AAFRRGHDRV FLIQGDKVWV YPPEKEKENP RSLQEEFPGV PSPLDAAVEC 150
HRGECQDEGV LFFQGTHTWF WDSTTKTTKE RLWPAVGNCS SAMRWISRYY 200
CFRGNQFLRF DPVTGHVDPK YPRDVRDYFM SCPGRGHAHR NATHRGDDRC 250
SPDLVLTALL SDNHGATYAF RGTHYWRLDT SRDGWHSWPI DHQWSHGPSA 300
VDAAFSWDDK LYLIQGTQVY IFLTKAGYTL VDNYPKQLEK ELGSPHGISL 350
DAVDATFVCP GTSRLHVMAG RKLWWLDLSL GAQGPWTELP WPHEKVDAAL 400
CTEKSLGPNS CSASGLGLYI VHGPHVYCYK DVEKLVSAKA LPQPQSVNSL 450
LGCHRSRGS 459
Length:459
Mass (Da):51,306
Last modified:October 1, 1996 - v1
Checksum:iDB06BB44C29789CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14751 mRNA. Translation: AAC48457.1.
PIRiA55486.
RefSeqiNP_999118.1. NM_213953.2.
UniGeneiSsc.4250.

Genome annotation databases

GeneIDi396998.
KEGGissc:396998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14751 mRNA. Translation: AAC48457.1 .
PIRi A55486.
RefSeqi NP_999118.1. NM_213953.2.
UniGenei Ssc.4250.

3D structure databases

ProteinModelPortali P50828.
SMRi P50828. Positions 50-453.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000015556.

Proteomic databases

PaxDbi P50828.
PRIDEi P50828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396998.
KEGGi ssc:396998.

Organism-specific databases

CTDi 3263.

Phylogenomic databases

eggNOGi NOG251805.
HOGENOMi HOG000112887.
HOVERGENi HBG005956.

Family and domain databases

Gene3Di 2.110.10.10. 2 hits.
InterProi IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR016358. Hemopexin_chordata.
IPR018486. Hemopexin_CS.
[Graphical view ]
Pfami PF00045. Hemopexin. 3 hits.
[Graphical view ]
PIRSFi PIRSF002551. Hemopexin_chordata. 1 hit.
SMARTi SM00120. HX. 5 hits.
[Graphical view ]
SUPFAMi SSF50923. SSF50923. 2 hits.
PROSITEi PS00024. HEMOPEXIN. 2 hits.
PS51642. HEMOPEXIN_2. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a mammalian hyaluronidase reveals identity with hemopexin, a serum heme-binding protein."
    Zhu L., Hope T.J., Hall J., Davies A., Stern M., Mueller-Eberhard U., Stern R., Parslow T.G.
    J. Biol. Chem. 269:32092-32097(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 29-48 AND 368-388.
    Tissue: Liver.

Entry informationi

Entry nameiHEMO_PIG
AccessioniPrimary (citable) accession number: P50828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear By similarity.

Caution

Lacks the conserved His heme iron ligand in position 81. There is a Gln in this position.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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