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Protein

Major capsid protein L1

Gene

L1

Organism
Human papillomavirus type 38
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein L1UniRule annotation
Gene namesi
Name:L1UniRule annotation
OrganismiHuman papillomavirus type 38
Taxonomic identifieri37959 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeBetapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009166 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=7 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001335221 – 510Major capsid protein L1Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi175Interchain (with C-438)UniRule annotation
Disulfide bondi438Interchain (with C-175)UniRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation. Interacts with protein E2; this interaction enhances E2-dependent replication and transcription activation.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP50814.
SMRiP50814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae L1 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900007S.

Family and domain databases

Gene3Di2.60.175.20. 1 hit.
HAMAPiMF_04002. PPV_L1. 1 hit.
InterProiView protein in InterPro
IPR002210. Capsid_L1_Papillomavir.
IPR036973. Capsid_L1_sf_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
PfamiView protein in Pfam
PF00500. Late_protein_L1. 1 hit.
PRINTSiPR00865. HPVCAPSIDL1.
SUPFAMiSSF88648. SSF88648. 1 hit.

Sequencei

Sequence statusi: Complete.

P50814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLWLPASGK IYLPPTPPVA RVQSTDEYVE RTDIYYHATS DRLLTVGHPY
60 70 80 90 100
FDVRSQDGQK IEVPKVSGNQ YRSFRVTFPD PNKFALADMS VYDPDKYRLV
110 120 130 140 150
WACKGLEIGR GQPLGVGTTG HPLFNKVRDT ENSSNYQNTS TDDRQNTSFD
160 170 180 190 200
PKQVQMFIIG CTPCLGEYWD KAPVCDNAGD QTGLCPPLEL KNSVIEDGDM
210 220 230 240 250
FDIGFGNINN KTLSFNRSDV SLDIVNETCK YPDFLTMSND VYGDSCFFFV
260 270 280 290 300
RREQCYARHY FVRGGAVGDA IPDGTVNQNH NYYLPAKNGQ GQRTLGNSTY
310 320 330 340 350
FPTVSGSLVT SDAQLFNRPF WLQRAQGHNN GILWGNQMFV TVADNTRNTN
360 370 380 390 400
FTISVSTENG GAQEYDSANI REYLRHVEEY QLSFILQLCK VPLNAEVLTQ
410 420 430 440 450
INAMNSGILE NWQLGFVPTP DNSVHDTYRY ITSKATKCPD AVPETEKEDP
460 470 480 490 500
FGQYTFWNVD MTEKLSLDLD QYPLGRKFLF QAGLQTARTR AVKRPLVRKS
510
SKSVKRKRTQ
Length:510
Mass (Da):57,692
Last modified:July 15, 1998 - v2
Checksum:i0FB61C7A2082E949
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti419T → A in AAA92836 (PubMed:7707535).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31787 Genomic DNA. Translation: AAA79456.1.
U21875 Genomic DNA. Translation: AAA92836.1.

Similar proteinsi

Entry informationi

Entry nameiVL1_HPV38
AccessioniPrimary (citable) accession number: P50814
Secondary accession number(s): Q80913
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: October 25, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families