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Protein

Major capsid protein L1

Gene

L1

Organism
Human papillomavirus type 36
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein L1UniRule annotation
Gene namesi
Name:L1UniRule annotation
OrganismiHuman papillomavirus type 36
Taxonomic identifieri37957 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeBetapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009167 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=7 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001335201 – 516Major capsid protein L1Add BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi175Interchain (with C-444)UniRule annotation
Disulfide bondi444Interchain (with C-175)UniRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation. Interacts with protein E2; this interaction enhances E2-dependent replication and transcription activation.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP50812.
SMRiP50812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae L1 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900007S.

Family and domain databases

Gene3Di2.60.175.20. 1 hit.
HAMAPiMF_04002. PPV_L1. 1 hit.
InterProiView protein in InterPro
IPR002210. Capsid_L1_Papillomavir.
IPR036973. Capsid_L1_sf_Papillomavir.
IPR011222. dsDNA_vir_gr_I_capsid.
PfamiView protein in Pfam
PF00500. Late_protein_L1. 1 hit.
PRINTSiPR00865. HPVCAPSIDL1.
SUPFAMiSSF88648. SSF88648. 1 hit.

Sequencei

Sequence statusi: Complete.

P50812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVWHSANGK VYLPPSTPVA RVQSTDEYIQ RTNIYYHAFS DRLLTVGHPY
60 70 80 90 100
FNVYDITGNK LEVPKVSGNQ HRVFRLKLPD PNRFALADMS VYNPDKERLV
110 120 130 140 150
WSCRGLEIGR GQPLGVGSTG HPLFNKLKDT ENSNSYIKSS KDDRQDTSFD
160 170 180 190 200
PKQIQMFIVG CTPCIGEHWD KAIPCEKERQ DNRLCPPIEL KTTYIEDGDM
210 220 230 240 250
ADIGFGNLNF KNLQESRSDV SLDIVNETCK YPDFLKMQND VYGDACFFYA
260 270 280 290 300
RREQCYARHF FVRGGKTGDD IPDARIDNGT FKNQFFIPGA DGQDQKTIGN
310 320 330 340 350
AMYYPTVSGS LVSSDAQLFN RPFWLQRAQG HNNGILWANQ MFITVVDNTR
360 370 380 390 400
NTNFSISIYN NNGALKDIND YTAEQFREYQ RHVEEYEISL ILQLCKVPLK
410 420 430 440 450
AEVLAQINAM NSSLLEDWQL GFVPTPDNPI QDTYRYIDSL ATRCPDKTPP
460 470 480 490 500
KEKEDPYKGL KFWDVDLTER LSLDLDQYSL GRKFLFQAGL QQTTVSGTKS
510
VSYRGFTRGT KRKRKQ
Length:516
Mass (Da):59,094
Last modified:October 1, 1996 - v1
Checksum:i5203F59597F16D72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31785 Genomic DNA. Translation: AAA79442.1.
U21873 Genomic DNA. Translation: AAA92834.1.

Similar proteinsi

Entry informationi

Entry nameiVL1_HPV36
AccessioniPrimary (citable) accession number: P50812
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families