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Protein

Protein E7

Gene

E7

Organism
Human papillomavirus type 36
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri55 – 93UniRule annotationAdd BLAST39

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processG1/S host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Modulation of host cell cycle by virus, Transcription, Transcription regulation, Viral immunoevasion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E7UniRule annotation
Gene namesi
Name:E7UniRule annotation
OrganismiHuman papillomavirus type 36
Taxonomic identifieri37957 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeBetapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009167 Componenti: Genome

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation
  • Note: Predominantly found in the host nucleus.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001334341 – 102Protein E7Add BLAST102

Post-translational modificationi

Highly phosphorylated.UniRule annotation

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer. Homooligomer. Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity. Interacts with host EP300; this interaction represses EP300 transcriptional activity. Interacts with protein E2; this interaction inhibits E7 oncogenic activity. Interacts with host TMEM173/STING; this interaction impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP50811.
SMRiP50811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 44DisorderedUniRule annotationAdd BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi27 – 31LXCXE motif; interaction with host RB1 and TMEM173/STINGUniRule annotation5
Motifi75 – 83Nuclear export signalUniRule annotation9

Sequence similaritiesi

Belongs to the papillomaviridae E7 protein family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri55 – 93UniRule annotationAdd BLAST39

Keywords - Domaini

Zinc-finger

Phylogenomic databases

OrthoDBiVOG090001L5.

Family and domain databases

HAMAPiMF_04004. PPV_E7. 1 hit.
InterProiView protein in InterPro
IPR000148. Papilloma_E7.
PfamiView protein in Pfam
PF00527. E7. 1 hit.
PIRSFiPIRSF003407. Papvi_E7. 1 hit.

Sequencei

Sequence statusi: Complete.

P50811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGKEVTVQD IVLELSEVQP EVLPVDLFCE EELPNEDTEE ELDTERIVFK
60 70 80 90 100
VIAPCGCSHC EVKLRVFVQA TEFGIRAFQQ LLTGDLQLLC PECRGNCEHG

GS
Length:102
Mass (Da):11,408
Last modified:October 1, 1996 - v1
Checksum:iB5C9137AEA905B17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31785 Genomic DNA. Translation: AAA79437.1.

Similar proteinsi

Entry informationi

Entry nameiVE7_HPV36
AccessioniPrimary (citable) accession number: P50811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families