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Protein

Protein E6

Gene

E6

Organism
Human papillomavirus type 36
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri41 – 77UniRule annotationAdd BLAST37
Zinc fingeri114 – 150UniRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Modulation of host cell apoptosis by virus, Transcription, Transcription regulation, Viral immunoevasion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E6UniRule annotation
Gene namesi
Name:E6UniRule annotation
OrganismiHuman papillomavirus type 36
Taxonomic identifieri37957 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeBetapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009167 Componenti: Genome

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001333561 – 157Protein E6Add BLAST157

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity. Interacts with host BAK1.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP50810.
SMRiP50810.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae E6 protein family.UniRule annotationCurated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri41 – 77UniRule annotationAdd BLAST37
Zinc fingeri114 – 150UniRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

OrthoDBiVOG0900011D.

Family and domain databases

HAMAPiMF_04006. HPV_E6. 1 hit.
InterProiView protein in InterPro
IPR001334. E6.
PfamiView protein in Pfam
PF00518. E6. 1 hit.

Sequencei

Sequence statusi: Complete.

P50810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQASEQQN ITEKEKEQLP LTIKGLSESL GIPFVDCLIP CNFCGKFLDY
60 70 80 90 100
LEACEFEVKK LSLIWKDYCV FACCRVCCGA TATYEFNQFY QQTVLGRDIE
110 120 130 140 150
LAAGRSIFEI DIRCQTCLAF LDIIEKLDCC GRGLPFHRVR NAWKGICRQC

KHFYNDW
Length:157
Mass (Da):18,123
Last modified:October 1, 1996 - v1
Checksum:iECB6CE02C0ECB126
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31785 Genomic DNA. Translation: AAA79436.1.

Similar proteinsi

Entry informationi

Entry nameiVE6_HPV36
AccessioniPrimary (citable) accession number: P50810
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families