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Protein

Minor capsid protein L2

Gene

L2

Organism
Human papillomavirus type 23
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transport, Viral penetration into host nucleus, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Minor capsid protein L2UniRule annotation
Gene namesi
Name:L2UniRule annotation
OrganismiHuman papillomavirus type 23
Taxonomic identifieri37955 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeBetapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009112 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001335901 – 519Minor capsid protein L2Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi19 ↔ 25UniRule annotation

Post-translational modificationi

Highly phosphorylated.UniRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with major capsid protein L1. Interacts with E2; this interaction inhibits E2 transcriptional activity but not the DNA replication function E2. Interacts with host HSPA8; this interaction is required for L2 nuclear translocation. Interacts with host importins KPNB2 and KPNB3. Forms a complex with importin alpha2-beta1 heterodimers via interaction with the importin alpha2 adapter. Interacts with host DYNLT1; this interaction is essential for virus intracellular transport during entry.UniRule annotation

Structurei

3D structure databases

SMRiP50797.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1 – 10Nuclear localization signalUniRule annotation10
Motifi511 – 518Nuclear localization signalUniRule annotation8

Sequence similaritiesi

Belongs to the papillomaviridae L2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000CV.

Family and domain databases

HAMAPiMF_04003. PPV_L2. 1 hit.
InterProiView protein in InterPro
IPR000784. Late_L2.
PfamiView protein in Pfam
PF00513. Late_protein_L2. 1 hit.

Sequencei

Sequence statusi: Complete.

P50797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAQRTKRA SVTDIYKGCK ASGTCPPDVL NKVEQNTLAD KILKYGSVGV
60 70 80 90 100
FFGGLGIGTG KGTGGATGYV PLRPGVRVGG TPTVVRPAVI PEIIGPTELI
110 120 130 140 150
PVDSIAPIDP EAPSIVSLTD SGAAADLFPS EAETIAEVHP TPVDIGIDTP
160 170 180 190 200
IVAGGRDAIL EVVDTNPPTR FSVTRTQYDN PSFQIISEST PITGEASLAD
210 220 230 240 250
HVFVFEGSGG QHVGAVTEEI ELDTYPSRYS FEIEEATPPR RTSTPIERIS
260 270 280 290 300
QEFRNLRRAL YNRRLTEQVQ VKNPLFLTTP SKLVRFQFDN PVFDEEVTQI
310 320 330 340 350
FERDVAEVEE PPDRDFLDID RLGRPLLTES TEGRIRLSRL GQRASIQTRS
360 370 380 390 400
GTRVGSRVHF YTDLSTINTE EPIELELLGE HSGDASVIEE PLQSTVIDMN
410 420 430 440 450
LDDVEAIQDT IDTADDYNSA DLLLDNAIEE FNNSQLVFGT SDRSSSAYSI
460 470 480 490 500
PRFESPRETI VYVQDIEGNQ VIYPGPTERP TIIFPLPSAP AVVIHTLDKS
510
FDYYLHPSLR KKRRKRKYL
Length:519
Mass (Da):57,173
Last modified:October 1, 1996 - v1
Checksum:i2E15CF64CE385228
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31781 Genomic DNA. Translation: AAA79413.1.

Similar proteinsi

Entry informationi

Entry nameiVL2_HPV23
AccessioniPrimary (citable) accession number: P50797
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 7, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families