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Protein

Minor capsid protein L2

Gene

L2

Organism
Human papillomavirus type 22
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transport, Viral penetration into host nucleus, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Minor capsid protein L2UniRule annotation
Gene namesi
Name:L2UniRule annotation
OrganismiHuman papillomavirus type 22
Taxonomic identifieri37954 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeBetapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009111 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001335891 – 524Minor capsid protein L2Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi19 ↔ 25UniRule annotation

Post-translational modificationi

Highly phosphorylated.UniRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with major capsid protein L1. Interacts with E2; this interaction inhibits E2 transcriptional activity but not the DNA replication function E2. Interacts with host HSPA8; this interaction is required for L2 nuclear translocation. Interacts with host importins KPNB2 and KPNB3. Forms a complex with importin alpha2-beta1 heterodimers via interaction with the importin alpha2 adapter. Interacts with host DYNLT1; this interaction is essential for virus intracellular transport during entry.UniRule annotation

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1 – 10Nuclear localization signalUniRule annotation10
Motifi516 – 523Nuclear localization signalUniRule annotation8

Sequence similaritiesi

Belongs to the papillomaviridae L2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000CV.

Family and domain databases

HAMAPiMF_04003. PPV_L2. 1 hit.
InterProiView protein in InterPro
IPR000784. Late_L2.
PfamiView protein in Pfam
PF00513. Late_protein_L2. 1 hit.

Sequencei

Sequence statusi: Complete.

P50796-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARARRTKRA SVTDIYKGCK ASGTCPPDVI NKVEQNTLAD KILKYGSVGV
60 70 80 90 100
FFGGLGISTG KGTGGPTGYI PLGQGPGVRV GATPTVVRPG VIPEIIGPTE
110 120 130 140 150
LIPVDSVTPI DPAAPSIVTL TDSSAGADLL PGEVETIAEV HPVPIDNVEL
160 170 180 190 200
DTPLVSGDRH AILEVTDANP PFRRTVTRTQ YHNPAFEIIS ESTPLIGEST
210 220 230 240 250
PSDHVFVFEG SGGVQVGDAN ESIELDTFPS RYSFDIEEPT PPRRVSTPIE
260 270 280 290 300
RISQEFRTLR RALYNRRLTE QVQVRDPLFI RSPSRLVRFQ FDNPVFDEEV
310 320 330 340 350
TQIFERDVAA VEEPPDRDFL DIERLGRPIL TETAEGRVRV SRLGQRASLS
360 370 380 390 400
TRSGARVGAR VHFFTDISTI NAEEPIELEL LGEHSGDSSV VQEPFESTIL
410 420 430 440 450
DVNIDNIPES LDTNIAETSV DYDSADLLLD NGVEDFSRSQ LVIGPSDRSL
460 470 480 490 500
PSITVPQFES PRETIVYIQD IEGNTVVYPK YEERPTIILP TPSGPAIIQS
510 520
PTHSSFDYYL HPSLRRKKRK RKYL
Length:524
Mass (Da):57,620
Last modified:October 1, 1996 - v1
Checksum:iE9738FE2C3B19CDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31780 Genomic DNA. Translation: AAA79406.1.

Similar proteinsi

Entry informationi

Entry nameiVL2_HPV22
AccessioniPrimary (citable) accession number: P50796
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 7, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families