Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Troponin T, cardiac muscle

Gene

Tnnt2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • protein binding, bridging Source: RGD
  • tropomyosin binding Source: UniProtKB
  • troponin C binding Source: UniProtKB
  • troponin I binding Source: RGD

GO - Biological processi

  • actin crosslink formation Source: RGD
  • cardiac muscle contraction Source: RGD
  • muscle contraction Source: RGD
  • muscle filament sliding Source: UniProtKB
  • negative regulation of ATPase activity Source: UniProtKB
  • positive regulation of ATPase activity Source: UniProtKB
  • protein heterooligomerization Source: RGD
  • regulation of heart contraction Source: UniProtKB
  • regulation of muscle contraction Source: RGD
  • regulation of muscle filament sliding speed Source: BHF-UCL
  • response to calcium ion Source: UniProtKB
  • ventricular cardiac muscle tissue morphogenesis Source: UniProtKB

Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

ReactomeiR-RNO-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, cardiac muscle
Short name:
TnTc
Alternative name(s):
Cardiac muscle troponin T
Short name:
cTnT
Gene namesi
Name:Tnnt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3882 Tnnt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861762 – 299Troponin T, cardiac muscleAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei205Phosphothreonine; by PKC/PRKCABy similarity1
Modified residuei209Phosphoserine; by PKC/PRKCABy similarity1
Modified residuei214Phosphothreonine; by PKC/PRKCA and RAF11 Publication1
Modified residuei295Phosphothreonine; by PKC/PRKCABy similarity1
Isoform 2 (identifier: P50753-2)
Modified residuei2PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Thr-214 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP50753
PRIDEiP50753

PTM databases

iPTMnetiP50753
PhosphoSitePlusiP50753

Expressioni

Gene expression databases

BgeeiENSRNOG00000033734
ExpressionAtlasiP50753 baseline and differential
GenevisibleiP50753 RN

Interactioni

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • protein binding, bridging Source: RGD
  • tropomyosin binding Source: UniProtKB
  • troponin C binding Source: UniProtKB
  • troponin I binding Source: RGD

Protein-protein interaction databases

BioGridi246955, 2 interactors
STRINGi10116.ENSRNOP00000049297

Structurei

3D structure databases

ProteinModelPortaliP50753
SMRiP50753
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

eggNOGiKOG3634 Eukaryota
ENOG410XS6A LUCA
GeneTreeiENSGT00390000013611
HOGENOMiHOG000231049
HOVERGENiHBG052790
InParanoidiP50753
KOiK12045
OMAiEVHFESR
OrthoDBiEOG091G0U67

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P50753-1) [UniParc]FASTAAdd to basket
Also known as: Embryonic

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDAEEEVVE YEEEQEEEDW SEEEEDEQEE AVEEEDGEAE PDPEGEAEAE
60 70 80 90 100
EDKAEEVGPD EEARDAEDGP VEDSKPKPSR LFMPNLVPPK IPDGERVDFD
110 120 130 140 150
DIHRKRMEKD LNELQTLIEA HFENRKKEEE ELISLKDRIE KRRAERAEQQ
160 170 180 190 200
RIRNEREKER QNRLAEERAR REEEENRRKA EDEARKKKAL SNMMHFGGYI
210 220 230 240 250
QKAQTERKSG KRQTEREKKK KILAERRKVL AIDHLNEDQL REKAKELWQS
260 270 280 290
IHNLEAEKFD LQEKFKQQKY EINVLRNRIN DNQKVSKTRG KAKVTGRWK
Length:299
Mass (Da):35,730
Last modified:January 23, 2007 - v2
Checksum:iB6042E2AD53B30B5
GO
Isoform 2 (identifier: P50753-2) [UniParc]FASTAAdd to basket
Also known as: Adult

The sequence of this isoform differs from the canonical sequence as follows:
     18-27: Missing.

Show »
Length:289
Mass (Da):34,452
Checksum:i47B2A588E82AE6FD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205T → A in AAB07676 (PubMed:1433301).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00665718 – 27Missing in isoform 2. Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26051 mRNA Translation: AAA42296.1
M26052 mRNA Translation: AAA42297.1
M80829 Genomic DNA Translation: AAB07676.1
PIRiA44781
B44781
S30443
RefSeqiNP_036808.1, NM_012676.1 [P50753-1]
XP_006249900.1, XM_006249838.2 [P50753-2]
XP_008767759.1, XM_008769537.2 [P50753-1]
XP_017454159.1, XM_017598670.1 [P50753-2]
UniGeneiRn.9965

Genome annotation databases

EnsembliENSRNOT00000050284; ENSRNOP00000041541; ENSRNOG00000033734 [P50753-2]
ENSRNOT00000084986; ENSRNOP00000069434; ENSRNOG00000033734 [P50753-1]
GeneIDi24837
KEGGirno:24837
UCSCiRGD:3882 rat [P50753-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTNNT2_RAT
AccessioniPrimary (citable) accession number: P50753
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health