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Protein

Kinetochore-associated protein 1

Gene

KNTC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.Curated3 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic cell cycle checkpoint Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB-KW
  • protein complex assembly Source: UniProtKB
  • regulation of exit from mitosis Source: UniProtKB
  • sister chromatid cohesion Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore-associated protein 1
Alternative name(s):
Rough deal homolog
Short name:
HsROD
Short name:
Rod
Short name:
hRod
Gene namesi
Name:KNTC1
Synonyms:KIAA0166
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:17255. KNTC1.

Subcellular locationi

  • Cytoplasm
  • Nucleus
  • Chromosomecentromerekinetochore
  • Cytoplasmcytoskeletonspindle

  • Note: Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles.

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • kinetochore microtubule Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
  • RZZ complex Source: UniProtKB
  • spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30184.

Polymorphism and mutation databases

BioMutaiKNTC1.
DMDMi1723117.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22092209Kinetochore-associated protein 1PRO_0000084312Add
BLAST

Proteomic databases

EPDiP50748.
MaxQBiP50748.
PaxDbiP50748.
PRIDEiP50748.

PTM databases

iPTMnetiP50748.
PhosphoSiteiP50748.

Expressioni

Tissue specificityi

High expression in testis.

Gene expression databases

BgeeiP50748.
CleanExiHS_KNTC1.
ExpressionAtlasiP50748. baseline and differential.
GenevisibleiP50748. HS.

Organism-specific databases

HPAiHPA025241.

Interactioni

Subunit structurei

Interacts with ZW10; the interaction is required for stable association with the kinetochore. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH; in the complex interacts directly with ZWILCH.3 Publications

Protein-protein interaction databases

BioGridi115084. 27 interactions.
DIPiDIP-36479N.
IntActiP50748. 6 interactions.
MINTiMINT-4989350.
STRINGi9606.ENSP00000328236.

Structurei

3D structure databases

ProteinModelPortaliP50748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4256. Eukaryota.
ENOG410YKFS. LUCA.
GeneTreeiENSGT00390000007883.
HOGENOMiHOG000001565.
HOVERGENiHBG052269.
InParanoidiP50748.
KOiK11577.
OMAiREQGEDC.
PhylomeDBiP50748.
TreeFamiTF101176.

Family and domain databases

InterProiIPR019527. RZZ-complex_KNTC1/ROD_C.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF10493. Rod_C. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P50748-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWNDIELLTN DDTGSGYLSV GSRKEHGTAL YQVDLLVKIS SEKASLNPKI
60 70 80 90 100
QACSLSDGFI IVADQSVILL DSICRSLQLH LVFDTEVDVV GLCQEGKFLL
110 120 130 140 150
VGERSGNLHL IHVTSKQTLL TNAFVQKAND ENRRTYQNLV IEKDGSNEGT
160 170 180 190 200
YYMLLLTYSG FFCITNLQLL KIQQAIENVD FSTAKKLQGQ IKSSFISTEN
210 220 230 240 250
YHTLGCLSLV AGDLASEVPV IIGGTGNCAF SKWEPDSSKK GMTVKNLIDA
260 270 280 290 300
EIIKGAKKFQ LIDNLLFVLD TDNVLSLWDI YTLTPVWNWP SLHVEEFLLT
310 320 330 340 350
TEADSPSSVT WQGITNLKLI ALTASANKKM KNLMVYSLPT MEILYSLEVS
360 370 380 390 400
SVSSLVQTGI STDTIYLLEG VCKNDPKLSE DSVSVLVLRC LTEALPENRL
410 420 430 440 450
SRLLHKHRFA EAESFAIQFG LDVELVYKVK SNHILEKLAL SSVDASEQTE
460 470 480 490 500
WQQLVDDAKE NLHKIQDDEF VVNYCLKAQW ITYETTQEML NYAKTRLLKK
510 520 530 540 550
EDKTALIYSD GLKEVLRAHA KLTTFYGAFG PEKFSGSSWI EFLNNEDDLK
560 570 580 590 600
DIFLQLKEGN LVCAQYLWLR HRANFESRFD VKMLESLLNS MSASVSLQKL
610 620 630 640 650
CPWFKNDVIP FVRRTVPEGQ IILAKWLEQA ARNLELTDKA NWPENGLQLA
660 670 680 690 700
EIFFTAEKTD ELGLASSWHW ISLKDYQNTE EVCQLRTLVN NLRELITLHR
710 720 730 740 750
KYNCKLALSD FEKENTTTIV FRMFDKVLAP ELIPSILEKF IRVYMREHDL
760 770 780 790 800
QEEELLLLYI EDLLNRCSSK STSLFETAWE AKAMAVIACL SDTDLIFDAV
810 820 830 840 850
LKIMYAAVVP WSAAVEQLVK QHLEMDHPKV KLLQESYKLM EMKKLLRGYG
860 870 880 890 900
IREVNLLNKE IMRVVRYILK QDVPSSLEDA LKVAQAFMLS DDEIYSLRII
910 920 930 940 950
DLIDREQGED CLLLLKSLPP AEAEKTAERV IIWARLALQE EPDHSKEGKA
960 970 980 990 1000
WRMSVAKTSV DILKILCDIQ KDNLQKKDEC EEMLKLFKEV ASLQENFEVF
1010 1020 1030 1040 1050
LSFEDYSNSS LVADLREQHI KAHEVAQAKH KPGSTPEPIA AEVRSPSMES
1060 1070 1080 1090 1100
KLHRQALALQ MSKQELEAEL TLRALKDGNI KTALKKCSDL FKYHCNADTG
1110 1120 1130 1140 1150
KLLFLTCQKL CQMLADNVPV TVPVGLNLPS MIHDLASQAA TICSPDFLLD
1160 1170 1180 1190 1200
ALELCKHTLM AVELSRQCQM DDCGILMKAS FGTHKDPYEE WSYSDFFSED
1210 1220 1230 1240 1250
GIVLESQMVL PVIYELISSL VPLAESKRYP LESTSLPYCS LNEGDGLVLP
1260 1270 1280 1290 1300
VINSISALLQ NLQESSQWEL ALRFVVGSFG TCLQHSVSNF MNATLSEKLF
1310 1320 1330 1340 1350
GETTLVKSRH VVMELKEKAV IFIRENATTL LHKVFNCRLV DLDLALGYCT
1360 1370 1380 1390 1400
LLPQKDVFEN LWKLIDKAWQ NYDKILAISL VGSELASLYQ EIEMGLKFRE
1410 1420 1430 1440 1450
LSTDAQWGIR LGKLGISFQP VFRQHFLTKK DLIKALVENI DMDTSLILEY
1460 1470 1480 1490 1500
CSTFQLDCDA VLQLFIETLL HNTNAGQGQG DASMDSAKRR HPKLLAKALE
1510 1520 1530 1540 1550
MVPLLTSTKD LVISLSGILH KLDPYDYEMI EVVLKVIERA DEKITNININ
1560 1570 1580 1590 1600
QALSILKHLK SYRRISPPVD LEYQYMLEHV ITLPSAAQTR LPFHLIFFGT
1610 1620 1630 1640 1650
AQNFWKILST ELSEESFPTL LLISKLMKFS LDTLYVSTAK HVFEKKLKPK
1660 1670 1680 1690 1700
LLKLTQAKSS TLINKEITKI TQTIESCLLS IVNPEWAVAI AISLAQDIPE
1710 1720 1730 1740 1750
GSFKISALKF CLYLAERWLQ NIPSQDEKRE KAEALLKKLH IQYRRSGTEA
1760 1770 1780 1790 1800
VLIAHKLNTE EYLRVIGKPA HLIVSLYEHP SINQRIQNSS GTDYPDIHAA
1810 1820 1830 1840 1850
AKEIAEVNEI NLEKVWDMLL EKWLCPSTKP GEKPSELFEL QEDEALRRVQ
1860 1870 1880 1890 1900
YLLLSRPIDY SSRMLFVFAT STTTTLGMHQ LTFAHRTRAL QCLFYLADKE
1910 1920 1930 1940 1950
TIESLFKKPI EEVKSYLRCI TFLASFETLN IPITYELFCS SPKEGMIKGL
1960 1970 1980 1990 2000
WKNHSHESMA VRLVTELCLE YKIYDLQLWN GLLQKLLGFN MIPYLRKVLK
2010 2020 2030 2040 2050
AISSIHSLWQ VPYFSKAWQR VIQIPLLSAS CPLSPDQLSD CSESLIAVLE
2060 2070 2080 2090 2100
CPVSGDLDLI GVARQYIQLE LPAFALACLM LMPHSEKRHQ QIKNFLGSCD
2110 2120 2130 2140 2150
PQVILKQLEE HMNTGQLAGF SHQIRSLILN NIINKKEFGI LAKTKYFQML
2160 2170 2180 2190 2200
KMHAMNTNNI TELVNYLAND LSLDEASVLI TEYSKHCGKP VPPDTAPCEI

LKMFLSGLS
Length:2,209
Mass (Da):250,749
Last modified:October 1, 1996 - v1
Checksum:i514C948733CBFDAC
GO
Isoform 2 (identifier: P50748-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1575: Missing.
     2011-2018: VPYFSKAW → RWRSCYVA
     2019-2209: Missing.

Note: No experimental confirmation available.
Show »
Length:443
Mass (Da):51,102
Checksum:i5BE89E57935B68AE
GO

Sequence cautioni

The sequence BAA11483.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti245 – 2451K → N.
Corresponds to variant rs7968222 [ dbSNP | Ensembl ].
VAR_051082
Natural varianti738 – 7381E → D.
Corresponds to variant rs17883249 [ dbSNP | Ensembl ].
VAR_051083
Natural varianti1506 – 15061T → M.
Corresponds to variant rs35315099 [ dbSNP | Ensembl ].
VAR_051084
Natural varianti1830 – 18301P → L.
Corresponds to variant rs7310898 [ dbSNP | Ensembl ].
VAR_051085
Natural varianti2021 – 20211V → G.
Corresponds to variant rs11837038 [ dbSNP | Ensembl ].
VAR_051086

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 15751575Missing in isoform 2. 1 PublicationVSP_057013Add
BLAST
Alternative sequencei2011 – 20188VPYFSKAW → RWRSCYVA in isoform 2. 1 PublicationVSP_057014
Alternative sequencei2019 – 2209191Missing in isoform 2. 1 PublicationVSP_057015Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79988 mRNA. Translation: BAA11483.2. Different initiation.
AK093470 mRNA. Translation: BAG52724.1.
AC026333 Genomic DNA. No translation available.
AC127002 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98334.1.
BC150278 mRNA. Translation: AAI50279.1.
CCDSiCCDS45002.1. [P50748-1]
RefSeqiNP_055523.1. NM_014708.4. [P50748-1]
XP_006719769.1. XM_006719706.2. [P50748-1]
UniGeneiHs.300559.
Hs.689083.

Genome annotation databases

EnsembliENST00000333479; ENSP00000328236; ENSG00000184445. [P50748-1]
GeneIDi9735.
KEGGihsa:9735.
UCSCiuc001ucv.4. human. [P50748-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79988 mRNA. Translation: BAA11483.2. Different initiation.
AK093470 mRNA. Translation: BAG52724.1.
AC026333 Genomic DNA. No translation available.
AC127002 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98334.1.
BC150278 mRNA. Translation: AAI50279.1.
CCDSiCCDS45002.1. [P50748-1]
RefSeqiNP_055523.1. NM_014708.4. [P50748-1]
XP_006719769.1. XM_006719706.2. [P50748-1]
UniGeneiHs.300559.
Hs.689083.

3D structure databases

ProteinModelPortaliP50748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115084. 27 interactions.
DIPiDIP-36479N.
IntActiP50748. 6 interactions.
MINTiMINT-4989350.
STRINGi9606.ENSP00000328236.

PTM databases

iPTMnetiP50748.
PhosphoSiteiP50748.

Polymorphism and mutation databases

BioMutaiKNTC1.
DMDMi1723117.

Proteomic databases

EPDiP50748.
MaxQBiP50748.
PaxDbiP50748.
PRIDEiP50748.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333479; ENSP00000328236; ENSG00000184445. [P50748-1]
GeneIDi9735.
KEGGihsa:9735.
UCSCiuc001ucv.4. human. [P50748-1]

Organism-specific databases

CTDi9735.
GeneCardsiKNTC1.
HGNCiHGNC:17255. KNTC1.
HPAiHPA025241.
MIMi607363. gene.
neXtProtiNX_P50748.
PharmGKBiPA30184.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4256. Eukaryota.
ENOG410YKFS. LUCA.
GeneTreeiENSGT00390000007883.
HOGENOMiHOG000001565.
HOVERGENiHBG052269.
InParanoidiP50748.
KOiK11577.
OMAiREQGEDC.
PhylomeDBiP50748.
TreeFamiTF101176.

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-68877. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSiKNTC1. human.
GenomeRNAii9735.
PROiP50748.
SOURCEiSearch...

Gene expression databases

BgeeiP50748.
CleanExiHS_KNTC1.
ExpressionAtlasiP50748. baseline and differential.
GenevisibleiP50748. HS.

Family and domain databases

InterProiIPR019527. RZZ-complex_KNTC1/ROD_C.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF10493. Rod_C. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
    DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores."
    Chan G.K.T., Jablonski S.A., Starr D.A., Goldberg M.L., Yen T.J.
    Nat. Cell Biol. 2:944-947(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore."
    Scaeerou F., Starr D.A., Piano F., Papoulas O., Karess R.E., Goldberg M.L.
    J. Cell Sci. 114:3103-3114(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions."
    Williams B.C., Li Z., Liu S., Williams E.V., Leung G., Yen T.J., Goldberg M.L.
    Mol. Biol. Cell 14:1379-1391(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZWILCH AND ZW10.
  9. "ZW10 links mitotic checkpoint signaling to the structural kinetochore."
    Kops G.J.P.L., Kim Y., Weaver B.A.A., Mao Y., McLeod I., Yates J.R. III, Tagaya M., Cleveland D.W.
    J. Cell Biol. 169:49-60(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE RZZ COMPLEX.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery."
    Civril F., Wehenkel A., Giorgi F.M., Santaguida S., Di Fonzo A., Grigorean G., Ciccarelli F.D., Musacchio A.
    Structure 18:616-626(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZWILCH, IDENTIFICATION IN THE RRZ COMPLEX.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKNTC1_HUMAN
AccessioniPrimary (citable) accession number: P50748
Secondary accession number(s): A7E2C4, B3KSG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.