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Protein

Biotin--protein ligase

Gene

HLCS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.

Catalytic activityi

ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] = AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase].
ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)].
ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)].
ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)].

Kineticsi

  1. KM=224 nM for biotin1 Publication
  1. Vmax=143.9 pmol/min/mg enzyme1 Publication

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • biotin-[acetyl-CoA-carboxylase] ligase activity Source: UniProtKB-EC
  • biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity Source: UniProtKB-EC
  • biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity Source: UniProtKB-EC
  • biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity Source: UniProtKB
  • biotin binding Source: UniProtKB
  • biotin-protein ligase activity Source: UniProtKB
  • enzyme binding Source: UniProtKB

GO - Biological processi

  • biotin metabolic process Source: Reactome
  • cell proliferation Source: UniProtKB
  • histone biotinylation Source: UniProtKB
  • histone modification Source: UniProtKB
  • protein biotinylation Source: UniProtKB
  • response to biotin Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS08386-MONOMER.
ReactomeiR-HSA-196780. Biotin transport and metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin--protein ligase (EC:6.3.4.-)
Alternative name(s):
Biotin apo-protein ligase
Including the following 4 domains:
Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC:6.3.4.9)
Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC:6.3.4.10)
Alternative name(s):
Holocarboxylase synthetase
Short name:
HCS
Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC:6.3.4.11)
Biotin--[acetyl-CoA-carboxylase] ligase (EC:6.3.4.15)
Gene namesi
Name:HLCS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:4976. HLCS.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • mitochondrion Source: UniProtKB-SubCell
  • nuclear lamina Source: UniProtKB
  • nuclear matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Holocarboxylase synthetase deficiency (HLCS deficiency)12 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neonatal form of multiple carboxylase deficiency, an autosomal recessive disorder of biotin metabolism, characterized by ketoacidosis, hyperammonemia, excretion of abnormal organic acid metabolites, and dermatitis. In holocarboxylase synthetase deficiency, clinical and biochemical symptoms improve dramatically with administration of biotin.
See also OMIM:253270
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03580042E → D in HLCS deficiency and a breast cancer sample; somatic mutation; conserves enzymatic wild-type activity; unknown pathological significance. 2 PublicationsCorresponds to variant rs61732504dbSNPEnsembl.1
Natural variantiVAR_046507183R → P in HLCS deficiency; has normal or low KM values for biotin (non-KM mutant). 1 Publication1
Natural variantiVAR_021218216L → R in HLCS deficiency; has normal or low KM values for biotin (non-KM mutant); growth of patients' fibroblasts is compromised compared with normal fibroblasts; patients cells are not sensitive to biotin-depletion from the media; growth rates cannot be restored by re-administration of biotin; enzyme activity is severely compromised and cannot be increased by additional biotin; turn-over rate for the mutant protein is double that of wild-type enzyme. 4 PublicationsCorresponds to variant rs28934602dbSNPEnsembl.1
Natural variantiVAR_005084237L → P in HLCS deficiency; has normal or low KM values for biotin (non-KM mutant). 5 PublicationsCorresponds to variant rs119103227dbSNPEnsembl.1
Natural variantiVAR_073074241G → W in HLCS deficiency. 1 Publication1
Natural variantiVAR_009196333V → E in HLCS deficiency; <10% activity; has normal or low KM values for biotin (non-KM mutant). 3 Publications1
Natural variantiVAR_046508360R → S in HLCS deficiency; 22% activity; shows elevated KM values for biotin (KM mutant) compared with that of the wild-type form. 1 Publication1
Natural variantiVAR_046509363V → D in HLCS deficiency; has normal or low KM values for biotin (non-KM mutant). 2 PublicationsCorresponds to variant rs769499327dbSNPEnsembl.1
Natural variantiVAR_046510456Y → C in HLCS deficiency; 0.2% activity. 1 PublicationCorresponds to variant rs781603756dbSNPEnsembl.1
Natural variantiVAR_009197462T → I in HLCS deficiency; <10% activity. 1 Publication1
Natural variantiVAR_046511470L → S in HLCS deficiency; 4.3% activity. 1 Publication1
Natural variantiVAR_073075505G → R in HLCS deficiency. 1 Publication1
Natural variantiVAR_013009508R → W in HLCS deficiency. 4 PublicationsCorresponds to variant rs119103229dbSNPEnsembl.1
Natural variantiVAR_021219511N → K in HLCS deficiency. 1 Publication1
Natural variantiVAR_046512518G → E in HLCS deficiency. 1 Publication1
Natural variantiVAR_046513547V → G in HLCS deficiency; 3.4% activity. 1 Publication1
Natural variantiVAR_009198550V → M in HLCS deficiency. 4 PublicationsCorresponds to variant rs119103231dbSNPEnsembl.1
Natural variantiVAR_009199571D → N in HLCS deficiency; almost no activity. 2 PublicationsCorresponds to variant rs119103228dbSNPEnsembl.1
Natural variantiVAR_009200581G → S in HLCS deficiency; <10% activity. 4 PublicationsCorresponds to variant rs119103230dbSNPEnsembl.1
Natural variantiVAR_021220582G → R in HLCS deficiency. 1 PublicationCorresponds to variant rs376899782dbSNPEnsembl.1
Natural variantiVAR_009201610Missing in HLCS deficiency; 14% of activity; shows elevated KM values for biotin (KM mutant) compared with that of the wild-type form. 3 Publications1
Natural variantiVAR_046514615D → Y in HLCS deficiency. 1 Publication1
Natural variantiVAR_046515634D → N in HLCS deficiency. 1 PublicationCorresponds to variant rs149399432dbSNPEnsembl.1
Natural variantiVAR_046516634D → Y in HLCS deficiency; 12% activity. 1 Publication1
Natural variantiVAR_046517715D → G in HLCS deficiency. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3141.
MalaCardsiHLCS.
MIMi253270. phenotype.
OpenTargetsiENSG00000159267.
Orphaneti79242. Holocarboxylase synthetase deficiency.
PharmGKBiPA29310.

Chemistry databases

ChEMBLiCHEMBL2062354.
DrugBankiDB00121. Biotin.

Polymorphism and mutation databases

BioMutaiHLCS.
DMDMi1705499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649791 – 726Biotin--protein ligaseAdd BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP50747.
MaxQBiP50747.
PaxDbiP50747.
PeptideAtlasiP50747.
PRIDEiP50747.

PTM databases

iPTMnetiP50747.
PhosphoSitePlusiP50747.

Expressioni

Tissue specificityi

Mostly expressed in muscle, placenta, in lesser extent in the brain, kidney, pancreas, liver and lung.

Gene expression databases

BgeeiENSG00000159267.
CleanExiHS_HLCS.
ExpressionAtlasiP50747. baseline and differential.
GenevisibleiP50747. HS.

Organism-specific databases

HPAiHPA017379.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
ACACBO007634EBI-3915568,EBI-2211739
POT1Q9NUX52EBI-3915568,EBI-752420

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109386. 9 interactors.
IntActiP50747. 4 interactors.
MINTiMINT-3018588.
STRINGi9606.ENSP00000338387.

Chemistry databases

BindingDBiP50747.

Structurei

3D structure databases

ProteinModelPortaliP50747.
SMRiP50747.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini463 – 652BPL/LPL catalyticPROSITE-ProRule annotationAdd BLAST190

Sequence similaritiesi

Belongs to the biotin--protein ligase family.Curated
Contains 1 BPL/LPL catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1536. Eukaryota.
COG0340. LUCA.
GeneTreeiENSGT00390000002960.
HOGENOMiHOG000095254.
HOVERGENiHBG004872.
InParanoidiP50747.
KOiK01942.
OMAiRDPLMQW.
OrthoDBiEOG091G0G5R.
PhylomeDBiP50747.
TreeFamiTF105860.

Family and domain databases

InterProiIPR019197. Biotin-prot_ligase_N.
IPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LPL_catalytic.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
PF09825. BPL_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDRLHMDNG LVPQKIVSVH LQDSTLKEVK DQVSNKQAQI LEPKPEPSLE
60 70 80 90 100
IKPEQDGMEH VGRDDPKALG EEPKQRRGSA SGSEPAGDSD RGGGPVEHYH
110 120 130 140 150
LHLSSCHECL ELENSTIESV KFASAENIPD LPYDYSSSLE SVADETSPER
160 170 180 190 200
EGRRVNLTGK APNILLYVGS DSQEALGRFH EVRSVLADCV DIDSYILYHL
210 220 230 240 250
LEDSALRDPW TDNCLLLVIA TRESIPEDLY QKFMAYLSQG GKVLGLSSSF
260 270 280 290 300
TFGGFQVTSK GALHKTVQNL VFSKADQSEV KLSVLSSGCR YQEGPVRLSP
310 320 330 340 350
GRLQGHLENE DKDRMIVHVP FGTRGGEAVL CQVHLELPPS SNIVQTPEDF
360 370 380 390 400
NLLKSSNFRR YEVLREILTT LGLSCDMKQV PALTPLYLLS AAEEIRDPLM
410 420 430 440 450
QWLGKHVDSE GEIKSGQLSL RFVSSYVSEV EITPSCIPVV TNMEAFSSEH
460 470 480 490 500
FNLEIYRQNL QTKQLGKVIL FAEVTPTTMR LLDGLMFQTP QEMGLIVIAA
510 520 530 540 550
RQTEGKGRGG NVWLSPVGCA LSTLLISIPL RSQLGQRIPF VQHLMSVAVV
560 570 580 590 600
EAVRSIPEYQ DINLRVKWPN DIYYSDLMKI GGVLVNSTLM GETFYILIGC
610 620 630 640 650
GFNVTNSNPT ICINDLITEY NKQHKAELKP LRADYLIARV VTVLEKLIKE
660 670 680 690 700
FQDKGPNSVL PLYYRYWVHS GQQVHLGSAE GPKVSIVGLD DSGFLQVHQE
710 720
GGEVVTVHPD GNSFDMLRNL ILPKRR
Length:726
Mass (Da):80,760
Last modified:October 1, 1996 - v1
Checksum:i855B8E52106D675F
GO

Sequence cautioni

The sequence AK307940 differs from that shown. Reason: Frameshift at position 169.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209P → T in AK307940 (PubMed:14702039).Curated1
Sequence conflicti463K → R in BAG36868 (PubMed:14702039).Curated1
Sequence conflicti558E → K in BAA13332 (PubMed:9037601).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03580042E → D in HLCS deficiency and a breast cancer sample; somatic mutation; conserves enzymatic wild-type activity; unknown pathological significance. 2 PublicationsCorresponds to variant rs61732504dbSNPEnsembl.1
Natural variantiVAR_046507183R → P in HLCS deficiency; has normal or low KM values for biotin (non-KM mutant). 1 Publication1
Natural variantiVAR_021218216L → R in HLCS deficiency; has normal or low KM values for biotin (non-KM mutant); growth of patients' fibroblasts is compromised compared with normal fibroblasts; patients cells are not sensitive to biotin-depletion from the media; growth rates cannot be restored by re-administration of biotin; enzyme activity is severely compromised and cannot be increased by additional biotin; turn-over rate for the mutant protein is double that of wild-type enzyme. 4 PublicationsCorresponds to variant rs28934602dbSNPEnsembl.1
Natural variantiVAR_005084237L → P in HLCS deficiency; has normal or low KM values for biotin (non-KM mutant). 5 PublicationsCorresponds to variant rs119103227dbSNPEnsembl.1
Natural variantiVAR_073074241G → W in HLCS deficiency. 1 Publication1
Natural variantiVAR_009196333V → E in HLCS deficiency; <10% activity; has normal or low KM values for biotin (non-KM mutant). 3 Publications1
Natural variantiVAR_046508360R → S in HLCS deficiency; 22% activity; shows elevated KM values for biotin (KM mutant) compared with that of the wild-type form. 1 Publication1
Natural variantiVAR_046509363V → D in HLCS deficiency; has normal or low KM values for biotin (non-KM mutant). 2 PublicationsCorresponds to variant rs769499327dbSNPEnsembl.1
Natural variantiVAR_046510456Y → C in HLCS deficiency; 0.2% activity. 1 PublicationCorresponds to variant rs781603756dbSNPEnsembl.1
Natural variantiVAR_009197462T → I in HLCS deficiency; <10% activity. 1 Publication1
Natural variantiVAR_046511470L → S in HLCS deficiency; 4.3% activity. 1 Publication1
Natural variantiVAR_073075505G → R in HLCS deficiency. 1 Publication1
Natural variantiVAR_013009508R → W in HLCS deficiency. 4 PublicationsCorresponds to variant rs119103229dbSNPEnsembl.1
Natural variantiVAR_021219511N → K in HLCS deficiency. 1 Publication1
Natural variantiVAR_046512518G → E in HLCS deficiency. 1 Publication1
Natural variantiVAR_046513547V → G in HLCS deficiency; 3.4% activity. 1 Publication1
Natural variantiVAR_009198550V → M in HLCS deficiency. 4 PublicationsCorresponds to variant rs119103231dbSNPEnsembl.1
Natural variantiVAR_009199571D → N in HLCS deficiency; almost no activity. 2 PublicationsCorresponds to variant rs119103228dbSNPEnsembl.1
Natural variantiVAR_009200581G → S in HLCS deficiency; <10% activity. 4 PublicationsCorresponds to variant rs119103230dbSNPEnsembl.1
Natural variantiVAR_021220582G → R in HLCS deficiency. 1 PublicationCorresponds to variant rs376899782dbSNPEnsembl.1
Natural variantiVAR_009201610Missing in HLCS deficiency; 14% of activity; shows elevated KM values for biotin (KM mutant) compared with that of the wild-type form. 3 Publications1
Natural variantiVAR_046514615D → Y in HLCS deficiency. 1 Publication1
Natural variantiVAR_046515634D → N in HLCS deficiency. 1 PublicationCorresponds to variant rs149399432dbSNPEnsembl.1
Natural variantiVAR_046516634D → Y in HLCS deficiency; 12% activity. 1 Publication1
Natural variantiVAR_046517715D → G in HLCS deficiency. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D23672 mRNA. Translation: BAA04902.1.
D87328 mRNA. Translation: BAA13332.1.
AP000697
, AP000703, AP000701, AP000698 Genomic DNA. Translation: BAA89434.1.
AB063285 Genomic DNA. Translation: BAB68550.1.
AK307940 mRNA. No translation available.
AK314189 mRNA. Translation: BAG36868.1.
AP001726 Genomic DNA. Translation: BAA95510.1.
AP001727 Genomic DNA. Translation: BAA95511.1.
CH471079 Genomic DNA. Translation: EAX09731.1.
CH471079 Genomic DNA. Translation: EAX09732.1.
BC060787 mRNA. Translation: AAH60787.1.
AJ001864 mRNA. Translation: CAA05056.1.
CCDSiCCDS13647.1.
PIRiS50833.
RefSeqiNP_000402.3. NM_000411.6.
NP_001229713.1. NM_001242784.1.
NP_001229714.1. NM_001242785.1.
XP_005261012.1. XM_005260955.3.
XP_005261013.1. XM_005260956.3.
XP_006724057.1. XM_006723994.2.
XP_006724058.1. XM_006723995.1.
XP_011527840.1. XM_011529538.1.
XP_011527841.1. XM_011529539.2.
XP_011527843.1. XM_011529541.2.
XP_016883819.1. XM_017028330.1.
UniGeneiHs.371350.
Hs.732538.

Genome annotation databases

EnsembliENST00000336648; ENSP00000338387; ENSG00000159267.
ENST00000399120; ENSP00000382071; ENSG00000159267.
ENST00000612277; ENSP00000479939; ENSG00000159267.
GeneIDi3141.
KEGGihsa:3141.
UCSCiuc002yvs.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D23672 mRNA. Translation: BAA04902.1.
D87328 mRNA. Translation: BAA13332.1.
AP000697
, AP000703, AP000701, AP000698 Genomic DNA. Translation: BAA89434.1.
AB063285 Genomic DNA. Translation: BAB68550.1.
AK307940 mRNA. No translation available.
AK314189 mRNA. Translation: BAG36868.1.
AP001726 Genomic DNA. Translation: BAA95510.1.
AP001727 Genomic DNA. Translation: BAA95511.1.
CH471079 Genomic DNA. Translation: EAX09731.1.
CH471079 Genomic DNA. Translation: EAX09732.1.
BC060787 mRNA. Translation: AAH60787.1.
AJ001864 mRNA. Translation: CAA05056.1.
CCDSiCCDS13647.1.
PIRiS50833.
RefSeqiNP_000402.3. NM_000411.6.
NP_001229713.1. NM_001242784.1.
NP_001229714.1. NM_001242785.1.
XP_005261012.1. XM_005260955.3.
XP_005261013.1. XM_005260956.3.
XP_006724057.1. XM_006723994.2.
XP_006724058.1. XM_006723995.1.
XP_011527840.1. XM_011529538.1.
XP_011527841.1. XM_011529539.2.
XP_011527843.1. XM_011529541.2.
XP_016883819.1. XM_017028330.1.
UniGeneiHs.371350.
Hs.732538.

3D structure databases

ProteinModelPortaliP50747.
SMRiP50747.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109386. 9 interactors.
IntActiP50747. 4 interactors.
MINTiMINT-3018588.
STRINGi9606.ENSP00000338387.

Chemistry databases

BindingDBiP50747.
ChEMBLiCHEMBL2062354.
DrugBankiDB00121. Biotin.

PTM databases

iPTMnetiP50747.
PhosphoSitePlusiP50747.

Polymorphism and mutation databases

BioMutaiHLCS.
DMDMi1705499.

Proteomic databases

EPDiP50747.
MaxQBiP50747.
PaxDbiP50747.
PeptideAtlasiP50747.
PRIDEiP50747.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336648; ENSP00000338387; ENSG00000159267.
ENST00000399120; ENSP00000382071; ENSG00000159267.
ENST00000612277; ENSP00000479939; ENSG00000159267.
GeneIDi3141.
KEGGihsa:3141.
UCSCiuc002yvs.4. human.

Organism-specific databases

CTDi3141.
DisGeNETi3141.
GeneCardsiHLCS.
HGNCiHGNC:4976. HLCS.
HPAiHPA017379.
MalaCardsiHLCS.
MIMi253270. phenotype.
609018. gene.
neXtProtiNX_P50747.
OpenTargetsiENSG00000159267.
Orphaneti79242. Holocarboxylase synthetase deficiency.
PharmGKBiPA29310.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1536. Eukaryota.
COG0340. LUCA.
GeneTreeiENSGT00390000002960.
HOGENOMiHOG000095254.
HOVERGENiHBG004872.
InParanoidiP50747.
KOiK01942.
OMAiRDPLMQW.
OrthoDBiEOG091G0G5R.
PhylomeDBiP50747.
TreeFamiTF105860.

Enzyme and pathway databases

BioCyciZFISH:HS08386-MONOMER.
ReactomeiR-HSA-196780. Biotin transport and metabolism.

Miscellaneous databases

ChiTaRSiHLCS. human.
GenomeRNAii3141.
PROiP50747.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159267.
CleanExiHS_HLCS.
ExpressionAtlasiP50747. baseline and differential.
GenevisibleiP50747. HS.

Family and domain databases

InterProiIPR019197. Biotin-prot_ligase_N.
IPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LPL_catalytic.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
PF09825. BPL_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBPL1_HUMAN
AccessioniPrimary (citable) accession number: P50747
Secondary accession number(s): B2RAH1, D3DSG6, Q99451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 163 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.