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P50745

- SH2B3_RAT

UniProt

P50745 - SH2B3_RAT

Protein

SH2B adapter protein 3

Gene

Sh2b3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.

    GO - Molecular functioni

    1. phosphate ion binding Source: RGD
    2. protein complex binding Source: RGD

    GO - Biological processi

    1. cell differentiation Source: Ensembl
    2. embryonic hemopoiesis Source: Ensembl
    3. intracellular signal transduction Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196232. Factors involved in megakaryocyte development and platelet production.
    REACT_197451. Regulation of KIT signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH2B adapter protein 3
    Alternative name(s):
    Lymphocyte adapter protein
    Lymphocyte-specific adapter protein Lnk
    Signal transduction protein Lnk
    Gene namesi
    Name:Sh2b3
    Synonyms:Lnk
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 12

    Organism-specific databases

    RGDi68411. Sh2b3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368SH2B adapter protein 3PRO_0000084456Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei356 – 3561PhosphotyrosineSequence Analysis

    Post-translational modificationi

    Tyrosine-phosphorylated upon T-cell activation. The tyrosine phosphorylation site is multifunctional and may associate with the SH2 domains of phospholipase C-gamma-1, GRB-2, and PI3-K upon T-cell receptor activation.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP50745.

    Expressioni

    Tissue specificityi

    Preferentially expressed by lymphocytes in lymph node and spleen.

    Gene expression databases

    ArrayExpressiP50745.
    GenevestigatoriP50745.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000038125.

    Structurei

    3D structure databases

    ProteinModelPortaliP50745.
    SMRiP50745. Positions 114-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini119 – 21799SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SH2B adapter family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG77816.
    GeneTreeiENSGT00530000063355.
    KOiK12459.
    OMAiTNTIRYL.
    OrthoDBiEOG70CR6F.
    PhylomeDBiP50745.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform Lnk4 (identifier: P50745-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGRTQGKHR PRVRTCPSLV PFDNPCWPPS HQPLPLQVGA PGHRVTSFLS    50
    GRAWPSYIPK GKHGLPGPRY VPDPWSLGVL GHVAPLRVTT TIFLPGASPG 100
    VMLDPACQKT DHFLSCYPWF HGPISRVRAA QLVQLQGPDA HGVFLVRQSE 150
    SRRGEYVLTF NLQGRAKHLR LVLTERGQCR VQHLHFPSVV DMLRHFQRSP 200
    IPLECGAACD VRLSGYVVVV SQAPGRKPKV VSRGGVTAST ARTKLPSWLR 250
    LLHGVIHVIS PGSSNTVLFP FSLPHWDSEL GHPHLSSAGC PPGHGAEALR 300
    GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYE MDSSSRSHLR 350
    AIDNQYTPLS QLCREANL 368
    Length:368
    Mass (Da):40,432
    Last modified:October 1, 1996 - v1
    Checksum:i624CC2ABA0332C87
    GO
    Isoform Lnk1 (identifier: P50745-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         225-278: Missing.

    Show »
    Length:314
    Mass (Da):34,602
    Checksum:i613AF6E05E5DF652
    GO
    Isoform Lnk2 (identifier: P50745-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-95: MAGRTQGKHR...LRVTTTIFLP → MPDNLYTFVL...PRGSTDSLDQ
         226-262: Missing.

    Show »
    Length:309
    Mass (Da):34,010
    Checksum:i4E64228C4EC2C784
    GO
    Isoform Lnk3 (identifier: P50745-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         14-38: Missing.
         226-262: Missing.

    Show »
    Length:306
    Mass (Da):33,663
    Checksum:iCEEBD99D1208689A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9595MAGRT…TIFLP → MPDNLYTFVLKVQGQTDIIF EVGDEQQLNSWLAELRASTG LGLEHLDTELPLSLVAEPGP AISPRGSTDSLDQ in isoform Lnk2. 1 PublicationVSP_004308Add
    BLAST
    Alternative sequencei14 – 3825Missing in isoform Lnk3. 1 PublicationVSP_004309Add
    BLAST
    Alternative sequencei225 – 27854Missing in isoform Lnk1. 1 PublicationVSP_004310Add
    BLAST
    Alternative sequencei226 – 26237Missing in isoform Lnk2 and isoform Lnk3. 1 PublicationVSP_004311Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24655 mRNA. Translation: AAC52351.1.
    U24654 mRNA. Translation: AAC52350.1.
    U24653 mRNA. Translation: AAC52349.1.
    U24652 mRNA. Translation: AAC52348.1.
    RefSeqiNP_113809.1. NM_031621.1. [P50745-1]
    UniGeneiRn.11228.

    Genome annotation databases

    EnsembliENSRNOT00000030583; ENSRNOP00000038125; ENSRNOG00000028198. [P50745-3]
    ENSRNOT00000073611; ENSRNOP00000066850; ENSRNOG00000028198. [P50745-1]
    ENSRNOT00000075776; ENSRNOP00000065142; ENSRNOG00000028198. [P50745-4]
    GeneIDi58838.
    KEGGirno:58838.
    UCSCiRGD:68411. rat. [P50745-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24655 mRNA. Translation: AAC52351.1 .
    U24654 mRNA. Translation: AAC52350.1 .
    U24653 mRNA. Translation: AAC52349.1 .
    U24652 mRNA. Translation: AAC52348.1 .
    RefSeqi NP_113809.1. NM_031621.1. [P50745-1 ]
    UniGenei Rn.11228.

    3D structure databases

    ProteinModelPortali P50745.
    SMRi P50745. Positions 114-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000038125.

    Proteomic databases

    PRIDEi P50745.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000030583 ; ENSRNOP00000038125 ; ENSRNOG00000028198 . [P50745-3 ]
    ENSRNOT00000073611 ; ENSRNOP00000066850 ; ENSRNOG00000028198 . [P50745-1 ]
    ENSRNOT00000075776 ; ENSRNOP00000065142 ; ENSRNOG00000028198 . [P50745-4 ]
    GeneIDi 58838.
    KEGGi rno:58838.
    UCSCi RGD:68411. rat. [P50745-1 ]

    Organism-specific databases

    CTDi 10019.
    RGDi 68411. Sh2b3.

    Phylogenomic databases

    eggNOGi NOG77816.
    GeneTreei ENSGT00530000063355.
    KOi K12459.
    OMAi TNTIRYL.
    OrthoDBi EOG70CR6F.
    PhylomeDBi P50745.

    Enzyme and pathway databases

    Reactomei REACT_196232. Factors involved in megakaryocyte development and platelet production.
    REACT_197451. Regulation of KIT signaling.

    Miscellaneous databases

    NextBioi 611402.
    PROi P50745.

    Gene expression databases

    ArrayExpressi P50745.
    Genevestigatori P50745.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase."
      Huang X., Li Y., Tanaka K., Moore K.G., Hayashi J.
      Proc. Natl. Acad. Sci. U.S.A. 92:11618-11622(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LNK1; LNK2; LNK3 AND LNK4).
      Strain: Fischer.
      Tissue: Lymph node.

    Entry informationi

    Entry nameiSH2B3_RAT
    AccessioniPrimary (citable) accession number: P50745
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3