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Protein

SH2B adapter protein 3

Gene

Sh2b3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.

GO - Molecular functioni

  • phosphate ion binding Source: RGD
  • signaling adaptor activity Source: InterPro

GO - Biological processi

  • cell differentiation Source: RGD
  • embryonic hemopoiesis Source: RGD
  • hemopoiesis Source: RGD
  • intracellular signal transduction Source: RGD
  • negative regulation of sprouting angiogenesis Source: RGD
  • regulation of regulatory T cell differentiation Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
SH2B adapter protein 3
Alternative name(s):
Lymphocyte adapter protein
Lymphocyte-specific adapter protein Lnk
Signal transduction protein Lnk
Gene namesi
Name:Sh2b3
Synonyms:Lnk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68411 Sh2b3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844561 – 368SH2B adapter protein 3Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei356PhosphotyrosineSequence analysis1

Post-translational modificationi

Tyrosine-phosphorylated upon T-cell activation. The tyrosine phosphorylation site is multifunctional and may associate with the SH2 domains of phospholipase C-gamma-1, GRB-2, and PI3-K upon T-cell receptor activation.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP50745
PRIDEiP50745

Expressioni

Tissue specificityi

Preferentially expressed by lymphocytes in lymph node and spleen.

Gene expression databases

GenevisibleiP50745 RN

Interactioni

Protein-protein interaction databases

BioGridi248640, 2 interactors
STRINGi10116.ENSRNOP00000066850

Structurei

3D structure databases

ProteinModelPortaliP50745
SMRiP50745
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 217SH2PROSITE-ProRule annotationAdd BLAST99

Sequence similaritiesi

Belongs to the SH2B adapter family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

InParanoidiP50745
KOiK12459
OrthoDBiEOG091G04RI
PhylomeDBiP50745

Family and domain databases

CDDicd10412 SH2_SH2B3, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR030523 SH2B
IPR030522 SH2B3
IPR035059 SH2B3_SH2
PANTHERiPTHR10872 PTHR10872, 1 hit
PTHR10872:SF1 PTHR10872:SF1, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Lnk4 (identifier: P50745-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRTQGKHR PRVRTCPSLV PFDNPCWPPS HQPLPLQVGA PGHRVTSFLS
60 70 80 90 100
GRAWPSYIPK GKHGLPGPRY VPDPWSLGVL GHVAPLRVTT TIFLPGASPG
110 120 130 140 150
VMLDPACQKT DHFLSCYPWF HGPISRVRAA QLVQLQGPDA HGVFLVRQSE
160 170 180 190 200
SRRGEYVLTF NLQGRAKHLR LVLTERGQCR VQHLHFPSVV DMLRHFQRSP
210 220 230 240 250
IPLECGAACD VRLSGYVVVV SQAPGRKPKV VSRGGVTAST ARTKLPSWLR
260 270 280 290 300
LLHGVIHVIS PGSSNTVLFP FSLPHWDSEL GHPHLSSAGC PPGHGAEALR
310 320 330 340 350
GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYE MDSSSRSHLR
360
AIDNQYTPLS QLCREANL
Length:368
Mass (Da):40,432
Last modified:October 1, 1996 - v1
Checksum:i624CC2ABA0332C87
GO
Isoform Lnk1 (identifier: P50745-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-278: Missing.

Show »
Length:314
Mass (Da):34,602
Checksum:i613AF6E05E5DF652
GO
Isoform Lnk2 (identifier: P50745-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: MAGRTQGKHR...LRVTTTIFLP → MPDNLYTFVL...PRGSTDSLDQ
     226-262: Missing.

Show »
Length:309
Mass (Da):34,010
Checksum:i4E64228C4EC2C784
GO
Isoform Lnk3 (identifier: P50745-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-38: Missing.
     226-262: Missing.

Show »
Length:306
Mass (Da):33,663
Checksum:iCEEBD99D1208689A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0043081 – 95MAGRT…TIFLP → MPDNLYTFVLKVQGQTDIIF EVGDEQQLNSWLAELRASTG LGLEHLDTELPLSLVAEPGP AISPRGSTDSLDQ in isoform Lnk2. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_00430914 – 38Missing in isoform Lnk3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_004310225 – 278Missing in isoform Lnk1. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_004311226 – 262Missing in isoform Lnk2 and isoform Lnk3. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24655 mRNA Translation: AAC52351.1
U24654 mRNA Translation: AAC52350.1
U24653 mRNA Translation: AAC52349.1
U24652 mRNA Translation: AAC52348.1
RefSeqiNP_113809.1, NM_031621.1 [P50745-1]
UniGeneiRn.11228

Genome annotation databases

GeneIDi58838
KEGGirno:58838
UCSCiRGD:68411 rat [P50745-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiSH2B3_RAT
AccessioniPrimary (citable) accession number: P50745
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health