SH2B adapter protein 3 - Rattus norvegicus (Rat)

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P50745 (SH2B3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 72. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
SH2B adapter protein 3

Alternative name(s):
Lymphocyte adapter protein
Lymphocyte-specific adapter protein Lnk
Signal transduction protein Lnk

Gene names

Name:	Sh2b3
Synonyms:	Lnk

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
Tissue specificity	Preferentially expressed by lymphocytes in lymph node and spleen.
Post-translational modification	Tyrosine-phosphorylated upon T-cell activation. The tyrosine phosphorylation site is multifunctional and may associate with the SH2 domains of phospholipase C-gamma-1, GRB-2, and PI3-K upon T-cell receptor activation.
Sequence similarities	Belongs to the SH2B adapter family. Contains 1 SH2 domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	SH2 domain
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: Compara embryonic hemopoiesis Inferred from electronic annotation. Source: Compara intracellular signal transduction Inferred from electronic annotation. Source: Compara
Molecular_function	phosphate ion binding Inferred from direct assay Ref.1. Source: RGD protein complex binding Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform Lnk4 (identifier: P50745-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Lnk1 (identifier: P50745-2) The sequence of this isoform differs from the canonical sequence as follows: 225-278: Missing.

Isoform Lnk2 (identifier: P50745-3) The sequence of this isoform differs from the canonical sequence as follows: 1-95: MAGRTQGKHR...LRVTTTIFLP → MPDNLYTFVL...PRGSTDSLDQ 226-262: Missing.

Isoform Lnk3 (identifier: P50745-4) The sequence of this isoform differs from the canonical sequence as follows: 14-38: Missing. 226-262: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 368

368

SH2B adapter protein 3

PRO_0000084456

Regions

Domain

119 – 217

SH2

Amino acid modifications

Modified residue

356

Phosphotyrosine Potential

Natural variations

Alternative sequence

1 – 95

MAGRT…TIFLP → MPDNLYTFVLKVQGQTDIIF EVGDEQQLNSWLAELRASTG LGLEHLDTELPLSLVAEPGP AISPRGSTDSLDQ in isoform Lnk2.

VSP_004308

Alternative sequence

14 – 38

Missing in isoform Lnk3.

VSP_004309

Alternative sequence

225 – 278

Missing in isoform Lnk1.

VSP_004310

Alternative sequence

226 – 262

Missing in isoform Lnk2 and isoform Lnk3.

VSP_004311

Sequences

Sequence		Length	Mass (Da)
Isoform Lnk4 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 624CC2ABA0332C87 Show »	FASTA	368	40,432
10 20 30 40 50 60 MAGRTQGKHR PRVRTCPSLV PFDNPCWPPS HQPLPLQVGA PGHRVTSFLS GRAWPSYIPK 70 80 90 100 110 120 GKHGLPGPRY VPDPWSLGVL GHVAPLRVTT TIFLPGASPG VMLDPACQKT DHFLSCYPWF 130 140 150 160 170 180 HGPISRVRAA QLVQLQGPDA HGVFLVRQSE SRRGEYVLTF NLQGRAKHLR LVLTERGQCR 190 200 210 220 230 240 VQHLHFPSVV DMLRHFQRSP IPLECGAACD VRLSGYVVVV SQAPGRKPKV VSRGGVTAST 250 260 270 280 290 300 ARTKLPSWLR LLHGVIHVIS PGSSNTVLFP FSLPHWDSEL GHPHLSSAGC PPGHGAEALR 310 320 330 340 350 360 GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYE MDSSSRSHLR AIDNQYTPLS QLCREANL « Hide
Isoform Lnk1 [UniParc]. Checksum: 613AF6E05E5DF652 Show »	FASTA	314	34,602
10 20 30 40 50 60 MAGRTQGKHR PRVRTCPSLV PFDNPCWPPS HQPLPLQVGA PGHRVTSFLS GRAWPSYIPK 70 80 90 100 110 120 GKHGLPGPRY VPDPWSLGVL GHVAPLRVTT TIFLPGASPG VMLDPACQKT DHFLSCYPWF 130 140 150 160 170 180 HGPISRVRAA QLVQLQGPDA HGVFLVRQSE SRRGEYVLTF NLQGRAKHLR LVLTERGQCR 190 200 210 220 230 240 VQHLHFPSVV DMLRHFQRSP IPLECGAACD VRLSGYVVVV SQAPELGHPH LSSAGCPPGH 250 260 270 280 290 300 GAEALRGQVT PPEQIFHLVP SPEELANSLR QLELESVSSA RDSDYEMDSS SRSHLRAIDN 310 QYTPLSQLCR EANL « Hide
Isoform Lnk2 [UniParc]. Checksum: 4E64228C4EC2C784 Show »	FASTA	309	34,010
10 20 30 40 50 60 MPDNLYTFVL KVQGQTDIIF EVGDEQQLNS WLAELRASTG LGLEHLDTEL PLSLVAEPGP 70 80 90 100 110 120 AISPRGSTDS LDQGASPGVM LDPACQKTDH FLSCYPWFHG PISRVRAAQL VQLQGPDAHG 130 140 150 160 170 180 VFLVRQSESR RGEYVLTFNL QGRAKHLRLV LTERGQCRVQ HLHFPSVVDM LRHFQRSPIP 190 200 210 220 230 240 LECGAACDVR LSGYVVVVSQ APGSSNTVLF PFSLPHWDSE LGHPHLSSAG CPPGHGAEAL 250 260 270 280 290 300 RGQVTPPEQI FHLVPSPEEL ANSLRQLELE SVSSARDSDY EMDSSSRSHL RAIDNQYTPL SQLCREANL « Hide
Isoform Lnk3 [UniParc]. Checksum: CEEBD99D1208689A Show »	FASTA	306	33,663
10 20 30 40 50 60 MAGRTQGKHR PRVGAPGHRV TSFLSGRAWP SYIPKGKHGL PGPRYVPDPW SLGVLGHVAP 70 80 90 100 110 120 LRVTTTIFLP GASPGVMLDP ACQKTDHFLS CYPWFHGPIS RVRAAQLVQL QGPDAHGVFL 130 140 150 160 170 180 VRQSESRRGE YVLTFNLQGR AKHLRLVLTE RGQCRVQHLH FPSVVDMLRH FQRSPIPLEC 190 200 210 220 230 240 GAACDVRLSG YVVVVSQAPG SSNTVLFPFS LPHWDSELGH PHLSSAGCPP GHGAEALRGQ 250 260 270 280 290 300 VTPPEQIFHL VPSPEELANS LRQLELESVS SARDSDYEMD SSSRSHLRAI DNQYTPLSQL CREANL « Hide

References

[1]

"Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase."
Huang X., Li Y., Tanaka K., Moore K.G., Hayashi J.
Proc. Natl. Acad. Sci. U.S.A. 92:11618-11622(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LNK1; LNK2; LNK3 AND LNK4).
Strain: Fischer.
Tissue: Lymph node.

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U24655 mRNA. Translation: AAC52351.1. U24654 mRNA. Translation: AAC52350.1. U24653 mRNA. Translation: AAC52349.1. U24652 mRNA. Translation: AAC52348.1.
IPI	IPI00201425. IPI00231239. IPI00231241. IPI00390498.
RefSeq	NP_113809.1. NM_031621.1.
UniGene	Rn.11228.
3D structure databases
ProteinModelPortal	P50745.
SMR	P50745. Positions 114-217.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000038125.
Proteomic databases
PRIDE	P50745.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000030583; ENSRNOP00000038125; ENSRNOG00000028198. ENSRNOT00000073611; ENSRNOP00000066850; ENSRNOG00000028198. ENSRNOT00000075776; ENSRNOP00000065142; ENSRNOG00000028198.
GeneID	58838.
KEGG	rno:58838.
UCSC	RGD:68411. rat.
Organism-specific databases
CTD	10019.
RGD	68411. Sh2b3.
Phylogenomic databases
eggNOG	NOG77816.
GeneTree	ENSGT00530000063355.
KO	K12459.
Gene expression databases
Genevestigator	P50745.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR000980. SH2. [Graphical view]
Pfam	PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN.
SMART	SM00252. SH2. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	611402.

Entry information

Entry name

SH2B3_RAT

Accession

Primary (citable) accession number: P50745

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents