Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P50745 (SH2B3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH2B adapter protein 3
Alternative name(s):
Lymphocyte adapter protein
Lymphocyte-specific adapter protein Lnk
Signal transduction protein Lnk
Gene names
Name:Sh2b3
Synonyms:Lnk
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.

Tissue specificity

Preferentially expressed by lymphocytes in lymph node and spleen.

Post-translational modification

Tyrosine-phosphorylated upon T-cell activation. The tyrosine phosphorylation site is multifunctional and may associate with the SH2 domains of phospholipase C-gamma-1, GRB-2, and PI3-K upon T-cell receptor activation.

Sequence similarities

Belongs to the SH2B adapter family.

Contains 1 SH2 domain.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform Lnk4 (identifier: P50745-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Lnk1 (identifier: P50745-2)

The sequence of this isoform differs from the canonical sequence as follows:
     225-278: Missing.
Isoform Lnk2 (identifier: P50745-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: MAGRTQGKHR...LRVTTTIFLP → MPDNLYTFVL...PRGSTDSLDQ
     226-262: Missing.
Isoform Lnk3 (identifier: P50745-4)

The sequence of this isoform differs from the canonical sequence as follows:
     14-38: Missing.
     226-262: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368SH2B adapter protein 3
PRO_0000084456

Regions

Domain119 – 21799SH2

Amino acid modifications

Modified residue3561Phosphotyrosine Potential

Natural variations

Alternative sequence1 – 9595MAGRT…TIFLP → MPDNLYTFVLKVQGQTDIIF EVGDEQQLNSWLAELRASTG LGLEHLDTELPLSLVAEPGP AISPRGSTDSLDQ in isoform Lnk2.
VSP_004308
Alternative sequence14 – 3825Missing in isoform Lnk3.
VSP_004309
Alternative sequence225 – 27854Missing in isoform Lnk1.
VSP_004310
Alternative sequence226 – 26237Missing in isoform Lnk2 and isoform Lnk3.
VSP_004311

Sequences

Sequence LengthMass (Da)Tools
Isoform Lnk4 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 624CC2ABA0332C87

FASTA36840,432
        10         20         30         40         50         60 
MAGRTQGKHR PRVRTCPSLV PFDNPCWPPS HQPLPLQVGA PGHRVTSFLS GRAWPSYIPK 

        70         80         90        100        110        120 
GKHGLPGPRY VPDPWSLGVL GHVAPLRVTT TIFLPGASPG VMLDPACQKT DHFLSCYPWF 

       130        140        150        160        170        180 
HGPISRVRAA QLVQLQGPDA HGVFLVRQSE SRRGEYVLTF NLQGRAKHLR LVLTERGQCR 

       190        200        210        220        230        240 
VQHLHFPSVV DMLRHFQRSP IPLECGAACD VRLSGYVVVV SQAPGRKPKV VSRGGVTAST 

       250        260        270        280        290        300 
ARTKLPSWLR LLHGVIHVIS PGSSNTVLFP FSLPHWDSEL GHPHLSSAGC PPGHGAEALR 

       310        320        330        340        350        360 
GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYE MDSSSRSHLR AIDNQYTPLS 


QLCREANL 

« Hide

Isoform Lnk1 [UniParc].

Checksum: 613AF6E05E5DF652
Show »

FASTA31434,602
Isoform Lnk2 [UniParc].

Checksum: 4E64228C4EC2C784
Show »

FASTA30934,010
Isoform Lnk3 [UniParc].

Checksum: CEEBD99D1208689A
Show »

FASTA30633,663

References

[1]"Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase."
Huang X., Li Y., Tanaka K., Moore K.G., Hayashi J.
Proc. Natl. Acad. Sci. U.S.A. 92:11618-11622(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LNK1; LNK2; LNK3 AND LNK4).
Strain: Fischer.
Tissue: Lymph node.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U24655 mRNA. Translation: AAC52351.1.
U24654 mRNA. Translation: AAC52350.1.
U24653 mRNA. Translation: AAC52349.1.
U24652 mRNA. Translation: AAC52348.1.
RefSeqNP_113809.1. NM_031621.1. [P50745-1]
UniGeneRn.11228.

3D structure databases

ProteinModelPortalP50745.
SMRP50745. Positions 114-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000038125.

Proteomic databases

PRIDEP50745.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000030583; ENSRNOP00000038125; ENSRNOG00000028198. [P50745-3]
ENSRNOT00000073611; ENSRNOP00000066850; ENSRNOG00000028198. [P50745-1]
ENSRNOT00000075776; ENSRNOP00000065142; ENSRNOG00000028198. [P50745-4]
GeneID58838.
KEGGrno:58838.
UCSCRGD:68411. rat. [P50745-1]

Organism-specific databases

CTD10019.
RGD68411. Sh2b3.

Phylogenomic databases

eggNOGNOG77816.
GeneTreeENSGT00530000063355.
KOK12459.
OMATNTIRYL.
OrthoDBEOG70CR6F.
PhylomeDBP50745.

Gene expression databases

ArrayExpressP50745.
GenevestigatorP50745.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
[Graphical view]
PfamPF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
SMARTSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio611402.
PROP50745.

Entry information

Entry nameSH2B3_RAT
AccessionPrimary (citable) accession number: P50745
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families