P50717 (LYS_HYPCU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Lysozyme EC=3.2.1.17 Alternative name(s): 1,4-beta-N-acetylmuramidase
Organism	Hyphantria cunea (Fall webworm moth)
Taxonomic identifier	39466 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Noctuoidea › Arctiidae › Hyphantria

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 142	122	Lysozyme		PRO_0000018507
Sites
	Active site	53	1	By similarity
	Active site	71	1	By similarity
Amino acid modifications
	Disulfide bond	27 ↔ 142		By similarity
	Disulfide bond	48 ↔ 131		By similarity
	Disulfide bond	83 ↔ 97		By similarity
	Disulfide bond	93 ↔ 111		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P50717-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 7A565C7748D4C127	FASTA	142	16,241
	10 20 30 40 50 60 MQKLAVFLFA IAAVCIHCEA KYYSTRCDLV RELRKQGFPE NQMGDWVCLV ENESGRKTDK 70 80 90 100 110 120 VGPVNKNGSK DYGLFQINDK YWCSNTRTPG KDCNVTCADL LLDDITKAST CAKKIFKRHN 130 140 FRAWYGWRNH CDGKTLPDTS NC

References

[1]	Park S.-S., Shin S.W., Park D.S., Kim M.K., Oh H.W., Park H.Y. Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U23786 mRNA. Translation: AAA84747.1.
3D structure databases
ProteinModelPortal	P50717.
SMR	P50717. Positions 25-142.
ModBase	Search...
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Enzyme and pathway databases
BRENDA	3.2.1.17. 15158.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYS_HYPCU

Accession

Primary (citable) accession number: P50717

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	August 10, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)