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Protein

Alpha-defensin 15

Gene

Defa15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably contributes to the antimicrobial barrier function of the small bowel mucosa.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-defensin 15
Alternative name(s):
Defensin-related cryptdin-15
Gene namesi
Name:Defa15
Synonyms:Defcr15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99586. Defa15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000684320 – 58By similarityAdd BLAST39
PeptideiPRO_000000684459 – 93Alpha-defensin 15Add BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 92By similarity
Disulfide bondi66 ↔ 81By similarity
Disulfide bondi71 ↔ 91By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP50713.
PRIDEiP50713.

Expressioni

Tissue specificityi

Paneth cells of the small bowel.

Structurei

3D structure databases

ProteinModelPortaliP50713.
SMRiP50713.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2. Eukaryota.
ENOG4111A2R. LUCA.
HOVERGENiHBG011703.
InParanoidiP50713.

Family and domain databases

InterProiView protein in InterPro
IPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR006080. Defensin_beta/alpha.
IPR002366. Defensin_propep.
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiView protein in Pfam
PF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiView protein in SMART
SM00048. DEFSN. 1 hit.
PROSITEiView protein in PROSITE
PS00269. DEFENSIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLVLLSAL VLLAFQVQAD PIQNTDEETK TEEQPGEDDQ AVSVSFGDPE
60 70 80 90
GSSLQEESLR DLVCYCRKRG CKRREHINGT CRKGHLLYML CCR
Length:93
Mass (Da):10,503
Last modified:November 1, 1997 - v2
Checksum:i2C507BAFD870E784
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03065 mRNA. Translation: AAA57182.1.
PIRiI48897.
UniGeneiMm.436573.

Similar proteinsi

Entry informationi

Entry nameiDFA15_MOUSE
AccessioniPrimary (citable) accession number: P50713
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: January 31, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome