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Protein

Glucan endo-1,3-beta-glucosidase

Gene
N/A
Organism
Prunus avium (Cherry) (Cerasus avium)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Most abundant soluble protein in ripe cherries.

Catalytic activityi

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, IgE-binding protein

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan endo-1,3-beta-glucosidase (EC:3.2.1.39)
Alternative name(s):
(1->3)-beta-glucan endohydrolase
Short name:
(1->3)-beta-glucanase
Allergen Pru a 2
Beta-1,3-endoglucanase
Thaumatin-like protein
Short name:
TLP
Allergen: Pru av 2
OrganismiPrunus avium (Cherry) (Cerasus avium)
Taxonomic identifieri42229 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeAmygdaloideaeAmygdaleaePrunus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds IgE in 50% of cherry-allergic patients.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3448 Pru av 2.0101
598 Pru av 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000003402124 – 245Glucan endo-1,3-beta-glucosidaseAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 244PROSITE-ProRule annotation1 Publication
Disulfide bondi80 ↔ 90PROSITE-ProRule annotation1 Publication
Disulfide bondi95 ↔ 102PROSITE-ProRule annotation1 Publication
Disulfide bondi150 ↔ 233PROSITE-ProRule annotation1 Publication
Disulfide bondi155 ↔ 216PROSITE-ProRule annotation1 Publication
Disulfide bondi163 ↔ 179PROSITE-ProRule annotation1 Publication
Disulfide bondi183 ↔ 192PROSITE-ProRule annotation1 Publication
Disulfide bondi193 ↔ 203PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Abundantly expressed in ripening fruit.

Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 30Combined sources6
Beta strandi32 – 34Combined sources3
Beta strandi36 – 42Combined sources7
Helixi43 – 45Combined sources3
Beta strandi61 – 65Combined sources5
Beta strandi68 – 82Combined sources15
Beta strandi88 – 93Combined sources6
Beta strandi97 – 101Combined sources5
Beta strandi113 – 118Combined sources6
Beta strandi124 – 130Combined sources7
Beta strandi135 – 137Combined sources3
Beta strandi139 – 145Combined sources7
Beta strandi153 – 155Combined sources3
Helixi159 – 162Combined sources4
Helixi165 – 167Combined sources3
Beta strandi168 – 170Combined sources3
Beta strandi176 – 179Combined sources4
Helixi182 – 186Combined sources5
Helixi189 – 192Combined sources4
Turni200 – 202Combined sources3
Helixi207 – 215Combined sources9
Turni226 – 229Combined sources4
Beta strandi231 – 235Combined sources5
Beta strandi238 – 243Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AHNX-ray1.30A24-245[»]
ProteinModelPortaliP50694
SMRiP50694
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP50694

Family & Domainsi

Sequence similaritiesi

Belongs to the thaumatin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.110.10, 1 hit
InterProiView protein in InterPro
IPR037176 Osmotin/thaumatin-like_sf
IPR001938 Thaumatin
IPR017949 Thaumatin_CS
PANTHERiPTHR31048 PTHR31048, 1 hit
PfamiView protein in Pfam
PF00314 Thaumatin, 1 hit
PIRSFiPIRSF002703 Thaumatin, 1 hit
PRINTSiPR00347 THAUMATIN
SMARTiView protein in SMART
SM00205 THN, 1 hit
SUPFAMiSSF49870 SSF49870, 1 hit
PROSITEiView protein in PROSITE
PS00316 THAUMATIN_1, 1 hit
PS51367 THAUMATIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P50694-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKTLVVVLS LSLTILSFGG AHAATISFKN NCPYMVWPGT LTSDQKPQLS
60 70 80 90 100
TTGFELASQA SFQLDTPVPW NGRFWARTGC STDASGKFVC ATADCASGQV
110 120 130 140 150
MCNGNGAIPP ATLAEFNIPA GGGQDFYDVS LVDGFNLPMS VTPQGGTGDC
160 170 180 190 200
KTASCPANVN AVCPSELQKK GSDGSVVACL SACVKFGTPQ YCCTPPQNTP
210 220 230 240
ETCPPTNYSE IFHNACPDAY SYAYDDKRGT FTCNGGPNYA ITFCP
Length:245
Mass (Da):25,707
Last modified:October 1, 1996 - v1
Checksum:iBE045DF46FCEA7CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32440 mRNA Translation: AAB38064.1

Similar proteinsi

Entry informationi

Entry nameiTLP_PRUAV
AccessioniPrimary (citable) accession number: P50694
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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