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P50693

- COX2_CULQU

UniProt

P50693 - COX2_CULQU

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Protein
Cytochrome c oxidase subunit 2
Gene
COII, CO2
Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper A Inferred
Metal bindingi196 – 1961Copper A Inferred
Metal bindingi200 – 2001Copper A Inferred
Metal bindingi204 – 2041Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Synonyms:CO2
Encoded oniMitochondrion
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei27 – 4822Helical; Reviewed prediction
Add
BLAST
Topological domaini49 – 6214Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei63 – 8220Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 228146Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Cytochrome c oxidase subunit 2
PRO_0000183561Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP50693.
SMRiP50693. Positions 1-227.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50693-1 [UniParc]FASTAAdd to Basket

« Hide

MATWANLGLQ NSSSPLMEQL NFFHDHTVLI LIMITVMITY VMGMLFFNKF    50
TNRYLLHGQT IEIIWTILPA IILMFIAFPS LRLLYLLDEI NSPLITLKAI 100
GHQWYWSYEY SNFMNLEFDS YMIPTNELDL NGFRLLDVDN RIILPLNNQI 150
RILVTATDVL HSWTVPSLGV KIDATPGRLN QTNFLINQSG LFFGQCSEIC 200
GANHSFMPIV IESIPMNYFI KWVSSQLN 228
Length:228
Mass (Da):26,319
Last modified:October 1, 1996 - v1
Checksum:i49B58BDA434D4CAB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81G → W in AAK14328. 1 Publication
Sequence conflicti135 – 1351L → S in AAK14328. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34351 Genomic DNA. Translation: AAA79167.1.
AF325716 Genomic DNA. Translation: AAK14328.1.
EU014281 Genomic DNA. Translation: ABS52760.1.
EU014282 Genomic DNA. Translation: ABS52761.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34351 Genomic DNA. Translation: AAA79167.1 .
AF325716 Genomic DNA. Translation: AAK14328.1 .
EU014281 Genomic DNA. Translation: ABS52760.1 .
EU014282 Genomic DNA. Translation: ABS52761.1 .

3D structure databases

ProteinModelPortali P50693.
SMRi P50693. Positions 1-227.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene for cytochrome c oxidase subunit II in the mitochondrial DNA of Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae)."
    Ho C.M., Liu Y.M., Wei Y.H., Hu S.T.
    J. Med. Entomol. 32:174-180(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Yi-lan.
    Tissue: Larva.
  2. "Molecular evolution of the mitochondrial cytochrome oxidase II gene in three mosquitoes."
    Wang J., Huang C.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Phylogenetic relationships of some common Culex mosquitoes of Bangladesh based on nuclear and mitochondrial DNA."
    Hasan A.U., Suguri S., Abedin S.M., Fujimoto C., Itaki R., Harada M., Zaman R.U., Al Mamun M.A., Rahman M.A.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_CULQU
AccessioniPrimary (citable) accession number: P50693
Secondary accession number(s): A7LGN8, Q9B813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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