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P50693 (COX2_CULQU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Synonyms:CO2
Encoded onMitochondrion
OrganismCulex quinquefasciatus (Southern house mosquito) (Culex pungens)
Taxonomic identifier7176 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Culicini › Culex › Culex ›

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Cytochrome c oxidase subunit 2
PRO_0000183561

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Potential
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Potential
Topological domain83 – 228146Mitochondrial intermembrane Potential

Sites

Metal binding1611Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable
Metal binding2041Copper A Probable

Experimental info

Sequence conflict81G → W in AAK14328. Ref.2
Sequence conflict1351L → S in AAK14328. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P50693 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 49B58BDA434D4CAB

FASTA22826,319
        10         20         30         40         50         60 
MATWANLGLQ NSSSPLMEQL NFFHDHTVLI LIMITVMITY VMGMLFFNKF TNRYLLHGQT 

        70         80         90        100        110        120 
IEIIWTILPA IILMFIAFPS LRLLYLLDEI NSPLITLKAI GHQWYWSYEY SNFMNLEFDS 

       130        140        150        160        170        180 
YMIPTNELDL NGFRLLDVDN RIILPLNNQI RILVTATDVL HSWTVPSLGV KIDATPGRLN 

       190        200        210        220 
QTNFLINQSG LFFGQCSEIC GANHSFMPIV IESIPMNYFI KWVSSQLN

« Hide

References

[1]"Gene for cytochrome c oxidase subunit II in the mitochondrial DNA of Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae)."
Ho C.M., Liu Y.M., Wei Y.H., Hu S.T.
J. Med. Entomol. 32:174-180(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Yi-lan.
Tissue: Larva.
[2]"Molecular evolution of the mitochondrial cytochrome oxidase II gene in three mosquitoes."
Wang J., Huang C.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Phylogenetic relationships of some common Culex mosquitoes of Bangladesh based on nuclear and mitochondrial DNA."
Hasan A.U., Suguri S., Abedin S.M., Fujimoto C., Itaki R., Harada M., Zaman R.U., Al Mamun M.A., Rahman M.A.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L34351 Genomic DNA. Translation: AAA79167.1.
AF325716 Genomic DNA. Translation: AAK14328.1.
EU014281 Genomic DNA. Translation: ABS52760.1.
EU014282 Genomic DNA. Translation: ABS52761.1.

3D structure databases

ProteinModelPortalP50693.
SMRP50693. Positions 1-227.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. Cupredoxin. 1 hit.
SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_CULQU
AccessionPrimary (citable) accession number: P50693
Secondary accession number(s): A7LGN8, Q9B813
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

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