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P50684 (COX2_COTJA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded onMitochondrion
OrganismCoturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Taxonomic identifier93934 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePerdicinaeCoturnix

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Cytochrome c oxidase subunit 2
PRO_0000183555

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4721Helical; Potential
Topological domain48 – 6114Mitochondrial matrix Potential
Transmembrane62 – 8120Helical; Potential
Topological domain82 – 227146Mitochondrial intermembrane Potential

Sites

Metal binding1601Copper A Probable
Metal binding1951Copper A Probable
Metal binding1991Copper A Probable
Metal binding2031Copper A Probable

Experimental info

Sequence conflict41H → Q in AAA76730. Ref.1
Sequence conflict151P → S in AAA76730. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P50684 [UniParc].

Last modified September 26, 2003. Version 2.
Checksum: 1C3F36750DDE3A4C

FASTA22725,627
        10         20         30         40         50         60 
MANHSQLGFQ DASSPIMEEL VEFHDHALMV ALAICSLVLY LLTLMLTQKL SSNTVDAQEV 

        70         80         90        100        110        120 
ELIWTILPAI VLVLLALPSL QILYMMDEIE EPDLTLKAIG HQWYWSYEYT DFKDLSFDSY 

       130        140        150        160        170        180 
MTPTTDLPQG HFRLLEVDHR IVIPMESPIR IIITADDVLH SWAVPTLGVK TDAIPGRLNQ 

       190        200        210        220 
TSFITTRPGV FYGQCSEICG ANHSYMPIVV ESTPLKHFET WSSLLSS 

« Hide

References

[1]"Nucleotide sequence of mitochondrial genes for COI, tRNAs Lys, Asp, Ser (UCN), COII and ATPases 8 and 6 of the quail Coturnix japonica."
Ramirez V., Morais R.
Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[2]"Complete sequence of the Japanese quail (Coturnix japonica) mitochondrial genome and its genetic relationship with related species."
Nishibori M., Hayashi T., Tsudzuki M., Yamamoto Y., Yasue H.
Anim. Genet. 32:380-385(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Blood.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U36794 Genomic DNA. Translation: AAA76730.1.
AP003195 Genomic DNA. Translation: BAB62918.1.
RefSeqNP_572017.1. NC_003408.1.

3D structure databases

ProteinModelPortalP50684.
SMRP50684. Positions 1-223.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID804666.

Organism-specific databases

CTD4513.

Phylogenomic databases

HOVERGENHBG012727.
ProtClustDBMTH00117.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_COTJA
AccessionPrimary (citable) accession number: P50684
Secondary accession number(s): Q8SEX0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 26, 2003
Last modified: April 16, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families