P50677 (COX3_THEVL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 3
Cytochrome c oxidase polypeptide III
Oxidase aa(3) subunit 3

Gene names

Name:

ctaE

Organism

Thermosynechococcus vulcanus (Synechococcus vulcanus)

Taxonomic identifier

32053 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Thermosynechococcus

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Cytochrome c oxidase subunit 3		PRO_0000183890
Regions
	Transmembrane	25 – 45	21	Helical; Potential
	Transmembrane	65 – 85	21	Helical; Potential
	Transmembrane	100 – 120	21	Helical; Potential
	Transmembrane	137 – 157	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P50677 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: F92C60DC0A0C0268	FASTA	201	22,886
	10 20 30 40 50 60 MQGTVESQGT AIAVDHAHEH PDFRVLGLLV FLISESLMFG GLFAAYLLLR GMHEQWPPEG 70 80 90 100 110 120 TEVELFVPTI NTLILISSSF VIHYGDVAIK KDDVRGMRKW YWITAAMGAV FLGGQVYEYL 130 140 150 160 170 180 TLGYGLRTNV FANCFYVMTG FHGLHVFIGI LLILGVIWRS RRPGHYNAQK HTGVAMAEIY 190 200 WHFVDVIWII LFTLLYILTR F

References

[1]	"The genes in the thermophilic cyanobacterium Synechococcus vulcanus encoding cytochrome-c oxidase." Sone N., Tano H., Ishizuka M. Biochim. Biophys. Acta 1183:130-138(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D16254 Genomic DNA. Translation: BAA41042.1.
3D structure databases
ProteinModelPortal	P50677.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_THEVL

Accession

Primary (citable) accession number: P50677

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program