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P50676

- COX1_THEVL

UniProt

P50676 - COX1_THEVL

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Protein

Cytochrome c oxidase subunit 1

Gene
ctaD
Organism
Thermosynechococcus vulcanus (Synechococcus vulcanus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B ion per subunit.
Binds 2 heme groups per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821Iron (heme A axial ligand) Inferred
Metal bindingi258 – 2581Copper B Inferred
Metal bindingi262 – 2621Copper B Inferred
Metal bindingi307 – 3071Copper B Inferred
Metal bindingi308 – 3081Copper B Inferred
Metal bindingi393 – 3931Iron (heme A3 axial ligand) Inferred
Metal bindingi395 – 3951Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Oxidase aa(3) subunit 1
Gene namesi
Name:ctaD
OrganismiThermosynechococcus vulcanus (Synechococcus vulcanus)
Taxonomic identifieri32053 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521Helical; Reviewed predictionAdd
BLAST
Transmembranei85 – 10521Helical; Reviewed predictionAdd
BLAST
Transmembranei120 – 14021Helical; Reviewed predictionAdd
BLAST
Transmembranei164 – 18421Helical; Reviewed predictionAdd
BLAST
Transmembranei211 – 23121Helical; Reviewed predictionAdd
BLAST
Transmembranei252 – 27221Helical; Reviewed predictionAdd
BLAST
Transmembranei284 – 30421Helical; Reviewed predictionAdd
BLAST
Transmembranei321 – 34121Helical; Reviewed predictionAdd
BLAST
Transmembranei355 – 37521Helical; Reviewed predictionAdd
BLAST
Transmembranei390 – 41021Helical; Reviewed predictionAdd
BLAST
Transmembranei426 – 44621Helical; Reviewed predictionAdd
BLAST
Transmembranei470 – 49021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Cytochrome c oxidase subunit 1PRO_0000183460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki258 ↔ 2621'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP50676.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50676-1 [UniParc]FASTAAdd to Basket

« Hide

MAQAQLPLDT PLSLPEHPKA WKWYDYFTFN VDHKVIGIQY LVTAFIFYLI    50
GGLMAVAMRT ELATADSDFL DPNLYNAFLT NHGTIMIFLW VVPAAIGGFG 100
NYLVPLMIGA RDMAFPRLNA LAFWLNPPAG ALLLASFLFG GAQAGWTSYP 150
PLSTITATTA QSMWILAIIL VGTSSILGSV NFIVTIWKMK VPSMRWNQLP 200
LFCWAMLATS LLALVSTPVL AAGLILLLFD INFGTSFYKP DAGGNVVIYQ 250
HLFWFYSHPA VYLMILPIFG IMSEVIPVHA RKPIFGYQAI AYSSLAICCV 300
GLFVWVHHMF TSGTPPWMRM FFTISTLIVA VPTGVKIFSW VATLWGGKIR 350
LNSAMLFAIG LMSMFVLGGL SGVTLGTAPV DIHVHDTYYV VAHFHYVLFG 400
GSVFGLYAGI YHWFPKMTGR LLDERLGILH FVLTLIGTNW TFLPMHELGL 450
KGMPRRVAMY DPQFEPVNLI CTIGAFVLAF SIIPFLINII WSWNKGKIAG 500
DNPWGGLTLE WTTSSPPLIE NWEVLPVVTK GPYDYGIERR QESTDEDHDE 550
QE 552
Length:552
Mass (Da):61,521
Last modified:October 1, 1996 - v1
Checksum:iEC6FDF34497CD061
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16254 Genomic DNA. Translation: BAA41041.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16254 Genomic DNA. Translation: BAA41041.1 .

3D structure databases

ProteinModelPortali P50676.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genes in the thermophilic cyanobacterium Synechococcus vulcanus encoding cytochrome-c oxidase."
    Sone N., Tano H., Ishizuka M.
    Biochim. Biophys. Acta 1183:130-138(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_THEVL
AccessioniPrimary (citable) accession number: P50676
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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