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P50671 (COX1_CHORO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismChoristoneura rosaceana (Oblique banded leafroller)
Taxonomic identifier27543 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaTortricoideaTortricidaeTortricinaeChoristoneura

Protein attributes

Sequence length274 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 274›274Cytochrome c oxidase subunit 1
PRO_0000183312

Regions

Transmembrane28 – 4821Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane212 – 23221Helical; Potential

Sites

Metal binding41Copper B Probable
Metal binding501Copper B Probable
Metal binding511Copper B Probable
Metal binding1361Iron (heme A3 axial ligand) Probable
Metal binding1381Iron (heme A axial ligand) Probable

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P50671 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F144A20D098B7692

FASTA27430,928
        10         20         30         40         50         60 
PEVYILILPG FGMISHIISQ ESGKKETFGC LGMIYAMMAI GLLGFVVWAH HMFTVGMDID 

        70         80         90        100        110        120 
TRAYFTSATM IIAVPTGIKI FSWLATLHGT QINYSPSMLW SLGFVFLFTV GGLTGVILAN 

       130        140        150        160        170        180 
SSIDVTLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWYPLF TGLAMNPYLL KIQFFTMFIG 

       190        200        210        220        230        240 
VNLTFFPQHF LGLAGMPRRY SDYPDIYTSW NIISSLGSYI SLIATMLMLM IIWESLINKR 

       250        260        270 
IILFPLNMNS SIEWYQNLPP AEHSYNELPI LSNF 

« Hide

References

[1]"Mitochondrial DNA sequence variation in the spruce budworm species complex (Choristoneura: Lepidoptera)."
Sperling F.A.H., Hickey D.A.
Mol. Biol. Evol. 11:656-665(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 205.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L19099 Genomic DNA. Translation: AAA53648.1.

3D structure databases

ProteinModelPortalP50671.
SMRP50671. Positions 1-267.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_CHORO
AccessionPrimary (citable) accession number: P50671
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways