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P50668

- COX1_CHOBI

UniProt

P50668 - COX1_CHOBI

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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Choristoneura biennis (Budworm moth)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme A axial ligand)Curated
Metal bindingi239 – 2391Copper BCurated
Metal bindingi243 – 2431Copper BCurated
Metal bindingi289 – 2891Copper BCurated
Metal bindingi290 – 2901Copper BCurated
Metal bindingi375 – 3751Iron (heme A3 axial ligand)Curated
Metal bindingi377 – 3771Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiChoristoneura biennis (Budworm moth)
Taxonomic identifieri27540 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaTortricoideaTortricidaeTortricinaeChoristoneura

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Transmembranei413 – 43321HelicalSequence AnalysisAdd
BLAST
Transmembranei451 – 47121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Cytochrome c oxidase subunit 1PRO_0000183308Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP50668.
SMRiP50668. Positions 2-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50668-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRKWLYSTN HKDIGTLYFM FGIWAGMVGT SLSLLIRVEL GNPGSLIGDD
60 70 80 90 100
QIYNTIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS
110 120 130 140 150
FWLLPPSIML LISSSIVENG AGTGWTVYPP LSSNIAHSGS SVDLAIFSLH
160 170 180 190 200
LAGISSILGA VNFITTIINM RPNNMSLDQM PLFVWSVGIT ALLLLLSLPV
210 220 230 240 250
LAGAITMLLT DRNLNTSFFD PAGGGDPILY QHLFWFFGHP EVYILILPGF
260 270 280 290 300
GMISHIISQE SGKKETFGCL GMIYAMMAIG LLGFVVWAHH MFTVGMDIDT
310 320 330 340 350
RAYFTSATMI IAVPTGIKIF SWLATLHGTQ INYSPSMLWS LGFVFLFTVG
360 370 380 390 400
GLTGVILANS SIDVTLHDTY YVVAHFHYVL SMGAVFAIMG GFVHWYPLFT
410 420 430 440 450
GLTLNPYLLK IQFFTMFIGV NLTFFPQHFL GLAGMPRRYS DYPDTYTSWN
460 470 480 490 500
IISSLGSYIS LIATMLMLMI IWESLINKRI ILFPLNMNSF IEWYQNLPPA
510
EHSYNELPIL SNF
Length:513
Mass (Da):57,133
Last modified:October 3, 2006 - v2
Checksum:i6A53317741512F4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19096 Genomic DNA. Translation: AAA53638.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19096 Genomic DNA. Translation: AAA53638.2 .

3D structure databases

ProteinModelPortali P50668.
SMRi P50668. Positions 2-506.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Roe A., Sperling F.A.H.
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Mitochondrial DNA sequence variation in the spruce budworm species complex (Choristoneura: Lepidoptera)."
    Sperling F.A.H., Hickey D.A.
    Mol. Biol. Evol. 11:656-665(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 240-513.
    Strain: 54.

Entry informationi

Entry nameiCOX1_CHOBI
AccessioniPrimary (citable) accession number: P50668
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3