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P50668

- COX1_CHOBI

UniProt

P50668 - COX1_CHOBI

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Protein
Cytochrome c oxidase subunit 1
Gene
COI
Organism
Choristoneura biennis (Budworm moth)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme A axial ligand) Inferred
Metal bindingi239 – 2391Copper B Inferred
Metal bindingi243 – 2431Copper B Inferred
Metal bindingi289 – 2891Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi375 – 3751Iron (heme A3 axial ligand) Inferred
Metal bindingi377 – 3771Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiChoristoneura biennis (Budworm moth)
Taxonomic identifieri27540 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaTortricoideaTortricidaeTortricinaeChoristoneura

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Reviewed prediction
Add
BLAST
Transmembranei62 – 8221Helical; Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Transmembranei182 – 20221Helical; Reviewed prediction
Add
BLAST
Transmembranei233 – 25321Helical; Reviewed prediction
Add
BLAST
Transmembranei267 – 28721Helical; Reviewed prediction
Add
BLAST
Transmembranei304 – 32421Helical; Reviewed prediction
Add
BLAST
Transmembranei337 – 35721Helical; Reviewed prediction
Add
BLAST
Transmembranei379 – 39921Helical; Reviewed prediction
Add
BLAST
Transmembranei413 – 43321Helical; Reviewed prediction
Add
BLAST
Transmembranei451 – 47121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Cytochrome c oxidase subunit 1
PRO_0000183308Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP50668.
SMRiP50668. Positions 2-506.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50668-1 [UniParc]FASTAAdd to Basket

« Hide

MVRKWLYSTN HKDIGTLYFM FGIWAGMVGT SLSLLIRVEL GNPGSLIGDD    50
QIYNTIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS 100
FWLLPPSIML LISSSIVENG AGTGWTVYPP LSSNIAHSGS SVDLAIFSLH 150
LAGISSILGA VNFITTIINM RPNNMSLDQM PLFVWSVGIT ALLLLLSLPV 200
LAGAITMLLT DRNLNTSFFD PAGGGDPILY QHLFWFFGHP EVYILILPGF 250
GMISHIISQE SGKKETFGCL GMIYAMMAIG LLGFVVWAHH MFTVGMDIDT 300
RAYFTSATMI IAVPTGIKIF SWLATLHGTQ INYSPSMLWS LGFVFLFTVG 350
GLTGVILANS SIDVTLHDTY YVVAHFHYVL SMGAVFAIMG GFVHWYPLFT 400
GLTLNPYLLK IQFFTMFIGV NLTFFPQHFL GLAGMPRRYS DYPDTYTSWN 450
IISSLGSYIS LIATMLMLMI IWESLINKRI ILFPLNMNSF IEWYQNLPPA 500
EHSYNELPIL SNF 513
Length:513
Mass (Da):57,133
Last modified:October 3, 2006 - v2
Checksum:i6A53317741512F4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19096 Genomic DNA. Translation: AAA53638.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19096 Genomic DNA. Translation: AAA53638.2 .

3D structure databases

ProteinModelPortali P50668.
SMRi P50668. Positions 2-506.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Roe A., Sperling F.A.H.
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Mitochondrial DNA sequence variation in the spruce budworm species complex (Choristoneura: Lepidoptera)."
    Sperling F.A.H., Hickey D.A.
    Mol. Biol. Evol. 11:656-665(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 240-513.
    Strain: 54.

Entry informationi

Entry nameiCOX1_CHOBI
AccessioniPrimary (citable) accession number: P50668
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2006
Last modified: September 3, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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