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P50666

- COX2_CAIMO

UniProt

P50666 - COX2_CAIMO

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Protein

Cytochrome c oxidase subunit 2

Gene
MT-CO2, COII, COXII, MTCO2
Organism
Cairina moschata (Muscovy duck)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi160 – 1601Copper A Inferred
Metal bindingi195 – 1951Copper A Inferred
Metal bindingi199 – 1991Copper A Inferred
Metal bindingi203 – 2031Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiCairina moschata (Muscovy duck)
Taxonomic identifieri8855 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeCairina

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei27 – 4721Helical; Reviewed predictionAdd
BLAST
Topological domaini48 – 6114Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei62 – 8120Helical; Reviewed predictionAdd
BLAST
Topological domaini82 – 228147Mitochondrial intermembrane Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Cytochrome c oxidase subunit 2PRO_0000183528Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP50666.
SMRiP50666. Positions 1-223.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012727.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50666-1 [UniParc]FASTAAdd to Basket

« Hide

MANHSQLGFQ DASSPIMEEL VEFHDHALIV ALAICSLVLY LLAHMLMEKL    50
SSNAVDAQEV ELIWTILPAI VLVLLALPSL QILYMMDEID EPDLTLKAIG 100
HQWYWSYEYT DFKDLSFDSY MIPTTDLPNG HFRLLEVDHR VVVPMESPIR 150
VIITAGDVLH SWAVPTLGVK TDAIPGRLNQ TSFIATRPGV FYGQCSEICG 200
ANHSYMPIVV ESTPLPYFET WSSLLSAS 228
Length:228
Mass (Da):25,523
Last modified:October 1, 1996 - v1
Checksum:iD34E9E93797DBCBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68508 Genomic DNA. Translation: CAA48520.1.
RefSeqiYP_001974582.1. NC_010965.1.

Genome annotation databases

GeneIDi6383232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68508 Genomic DNA. Translation: CAA48520.1 .
RefSeqi YP_001974582.1. NC_010965.1.

3D structure databases

ProteinModelPortali P50666.
SMRi P50666. Positions 1-223.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6383232.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

HOVERGENi HBG012727.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A gene cytochrome C oxidase subunit II in duck mitochondrial DNA: structural features and sequence evolution."
    Pan Y.F., Lee Y.H.W., Wei Y.H., Chiang A.N.
    Biochem. Int. 30:479-489(1993)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Muscovy shinney duck.
    Tissue: Liver.

Entry informationi

Entry nameiCOX2_CAIMO
AccessioniPrimary (citable) accession number: P50666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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