P50657 (COX3_ANAPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:	MT-CO3
Synonyms:	COIII, COXIII, MTCO3

Encoded on

Mitochondrion

Organism

Anas platyrhynchos (Domestic duck) (Anas boschas)

Taxonomic identifier

8839 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Anseriformes › Anatidae › Anas

Protein attributes

Sequence length	86 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›86	›86	Cytochrome c oxidase subunit 3		PRO_0000183731
Regions
	Transmembrane	15 – 35	21	Helical; Potential
	Transmembrane	38 – 58	21	Helical; Potential
Experimental info
	Non-terminal residue	86	1

Sequences

	Sequence		Length	Mass (Da)
	P50657 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 254F9B780A044400	FASTA	86	9,768
	10 20 30 40 50 60 MAHQAHSYHM VDPSPWPIFG AAAALLTTSG LVMWFHYNSS ILLAAGLLSM LLVMLQWWRE 70 80 IVRESTFQGH HTPTVQKGLR YGMILF

References

[1]	"Molecular characterization and evolution of a duck mitochondrial genome." Ramirez V., Savoie P., Morais R. J. Mol. Evol. 37:296-310(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Pekin breed. Tissue: Liver.
[2]	"Gene organization of the Peking duck mitochondrial genome." Desjardins P., Ramirez V., Morais R. Curr. Genet. 17:515-518(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-85. Strain: Pekin breed. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22476 Genomic DNA. Translation: AAA72040.2. X55527 Genomic DNA. Translation: CAA39144.1.
3D structure databases
ProteinModelPortal	P50657.
SMR	P50657. Positions 1-86.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_ANAPL

Accession

Primary (citable) accession number: P50657

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program