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P50656 (COX1_ANAPL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded onMitochondrion
OrganismAnas platyrhynchos (Domestic duck) (Anas boschas) [Complete proteome]
Taxonomic identifier8839 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnas

Protein attributes

Sequence length102 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›102›102Cytochrome c oxidase subunit 1
PRO_0000183281

Regions

Transmembrane18 – 3821Helical; Potential
Transmembrane64 – 8421Helical; Potential

Sites

Metal binding621Iron (heme A axial ligand) Probable

Experimental info

Sequence conflict47 – 504TLLG → PPGL in CAA39146. Ref.2
Sequence conflict591V → D in CAA39146. Ref.2
Non-terminal residue1021

Sequences

Sequence LengthMass (Da)Tools
P50656 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 5E1B143E869F8115

FASTA10211,414
        10         20         30         40         50         60 
MTFINRWLFS TNHKDIGTLY LIFGAWAGMI GTALSLLIRA ELGQPGTLLG DDQIYNVIVT 

        70         80         90        100 
RHAFVMIFFM VMPIMIGGFG NWLVPLMIGA PDMAFPRMNN MS 

« Hide

References

[1]"Molecular characterization and evolution of a duck mitochondrial genome."
Ramirez V., Savoie P., Morais R.
J. Mol. Evol. 37:296-310(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Pekin breed.
Tissue: Liver.
[2]"Gene organization of the Peking duck mitochondrial genome."
Desjardins P., Ramirez V., Morais R.
Curr. Genet. 17:515-518(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-59.
Strain: Pekin breed.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22480 Unassigned DNA. Translation: AAA16541.1.
X55529 Genomic DNA. Translation: CAA39146.1.

3D structure databases

ProteinModelPortalP50656.
SMRP50656. Positions 3-102.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_ANAPL
AccessionPrimary (citable) accession number: P50656
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways