P50656 (COX1_ANAPL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 1
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide I

Gene names

Name:	MT-CO1
Synonyms:	COI, COXI, MTCO1

Encoded on

Mitochondrion

Organism

Anas platyrhynchos (Domestic duck) (Anas boschas)

Taxonomic identifier

8839 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Anseriformes › Anatidae › Anas

Protein attributes

Sequence length	102 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›102	›102	Cytochrome c oxidase subunit 1		PRO_0000183281
Regions
	Transmembrane	18 – 38	21	Helical; Potential
	Transmembrane	64 – 84	21	Helical; Potential
Sites
	Metal binding	62	1	Iron (heme A axial ligand) Probable
Experimental info
	Sequence conflict	47 – 50	4	TLLG → PPGL in CAA39146. Ref.2
	Sequence conflict	59	1	V → D in CAA39146. Ref.2
	Non-terminal residue	102	1

Sequences

	Sequence		Length	Mass (Da)
	P50656 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 5E1B143E869F8115	FASTA	102	11,414
	10 20 30 40 50 60 MTFINRWLFS TNHKDIGTLY LIFGAWAGMI GTALSLLIRA ELGQPGTLLG DDQIYNVIVT 70 80 90 100 RHAFVMIFFM VMPIMIGGFG NWLVPLMIGA PDMAFPRMNN MS

References

[1]	"Molecular characterization and evolution of a duck mitochondrial genome." Ramirez V., Savoie P., Morais R. J. Mol. Evol. 37:296-310(1993) [PubMed: 8230253] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Pekin breed. Tissue: Liver.
[2]	"Gene organization of the Peking duck mitochondrial genome." Desjardins P., Ramirez V., Morais R. Curr. Genet. 17:515-518(1990) [PubMed: 2390786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-59. Strain: Pekin breed. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22480 Unassigned DNA. Translation: AAA16541.1. X55529 Genomic DNA. Translation: CAA39146.1.
3D structure databases
ProteinModelPortal	P50656.
SMR	P50656. Positions 3-102.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000883. Cyt_c_Oxase_su1. IPR023616. Cyt_c_Oxase_su1_dom. [Graphical view]
Gene3D	G3DSA:1.20.210.10. COX1. 1 hit.
PANTHER	PTHR10422. COX1. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
SUPFAM	SSF81442. COX1. 1 hit.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX1_ANAPL

Accession

Primary (citable) accession number: P50656

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 31, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program