Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fanconi anemia group C protein homolog

Gene

Fancc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity).By similarity

GO - Biological processi

  • brain morphogenesis Source: MGI
  • cellular response to oxidative stress Source: MGI
  • gamete generation Source: MGI
  • germ cell development Source: MGI
  • myeloid cell homeostasis Source: MGI
  • neuronal stem cell population maintenance Source: MGI
  • nucleotide-excision repair Source: MGI
  • removal of superoxide radicals Source: MGI

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-MMU-6783310 Fanconi Anemia Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group C protein homolog
Short name:
Protein FACC
Gene namesi
Name:Fancc
Synonyms:Fac, Facc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:95480 Fancc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000871851 – 591Fanconi anemia group C protein homologAdd BLAST591

Proteomic databases

PRIDEiP50652

PTM databases

iPTMnetiP50652
PhosphoSitePlusiP50652

Expressioni

Tissue specificityi

Ubiquitous.

Developmental stagei

Embryos from days 8-13 show a uniform pattern of expression with somewhat higher level expression in days 8 and 9 in the head mesenchyme as compared to the rest of the embryo. Higher levels of expression are seen in the developing bones of 14 to 16 day embryos. In the 15 day embryo it is detected in the perichondrium and the marrow of the iliac bone and perichondrium of the ribs and vertebrae. In the 16 day embryo it is detected in the perichondrial layer of the developing digits of the forelimb, outer root sheath of the hair follicles of the upper jaw and in the perichondrium of the vertebrae.

Gene expression databases

BgeeiENSMUSG00000021461
CleanExiMM_FANCC
ExpressionAtlasiP50652 baseline and differential
GenevisibleiP50652 MM

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70. Interacts with ZBTB32. Upon IFNG induction, interacts with STAT1. Interacts with CDK1. Interacts with EIF2AK2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi1995927 interactors.
IntActiP50652 5 interactors.
MINTiP50652

Structurei

3D structure databases

ProteinModelPortaliP50652
SMRiP50652
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000016390
HOGENOMiHOG000043097
HOVERGENiHBG051548
InParanoidiP50652
KOiK10890
OMAiHFGGWAD
OrthoDBiEOG091G0442

Family and domain databases

InterProiView protein in InterPro
IPR000686 Fanconi
PANTHERiPTHR16798 PTHR16798, 1 hit
PfamiView protein in Pfam
PF02106 Fanconi_C, 1 hit
PIRSFiPIRSF018417 FACC_protein, 1 hit
PRINTSiPR00494 FANCONICGENE

Sequencei

Sequence statusi: Complete.

P50652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQESADLAS DCQSWLQKLS AWEQASSEET QKDTCLHLSG FQEFLRQMYE
60 70 80 90 100
ILKEMDSDAI LERFPTIGQL LAKACWNPLI LAYDESQKIV IWCLCCLMNK
110 120 130 140 150
EPRTSAESGL NSWIRGLLSH VLSAFRFDMK EVCLFTKSLG YESIDYYPSL
160 170 180 190 200
LKNMVLSLVS ELRESHLNGL STQSRMAPER MMSLSEVCVP LVTLPDMEPL
210 220 230 240 250
VEALLTYHGH EPQEVLAPEF FEAVNEAFLS EKIVLPTSSV VSLWFRHLPS
260 270 280 290 300
LEKATLHLFE KLFSSKIICL RRMECCIRES FLPQAACQPA IFRIVDEMFR
310 320 330 340 350
FVLLETDGAP EVLAALQVFT SCLVEALKKE NKQLTFALRT YFPYGAPCLA
360 370 380 390 400
AALSQHPEAI PQGHRLQPLL HISQLLREAV EDCTRGSPRN PFESWFLFVH
410 420 430 440 450
FGGWVDLAVA ELLLREEAEP PAGLLWLLVF YYSPQDGSQQ REQSMVELKV
460 470 480 490 500
LINRLLMLLR SGPLSATDLQ EAAESPSGDP RPPVCGQLVR RLLLSLLLWT
510 520 530 540 550
PEGHAIVWEA VTHGPTFEIT GPGCCPRIWR STRPQHRPRA HLCCTEMAHT
560 570 580 590
DAVIHEIIGF LDQTLYRSQH LCVEASRKLA RDLLKELQAQ V
Length:591
Mass (Da):66,979
Last modified:July 27, 2011 - v2
Checksum:i97DA796F55D8A68A
GO

Sequence cautioni

The sequence AAA37590 differs from that shown. Aberrant splicing.Curated
The sequence AAA37590 differs from that shown. Reason: Frameshift at position 81.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235L → V in AAA37590 (PubMed:7689006).Curated1
Sequence conflicti296D → H in AAA37590 (PubMed:7689006).Curated1
Sequence conflicti305E → K in AAA37590 (PubMed:7689006).Curated1
Sequence conflicti533R → K in AAA37590 (PubMed:7689006).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08266 mRNA Translation: AAA37590.1 Sequence problems.
AC130827 Genomic DNA No translation available.
AC154638 Genomic DNA No translation available.
CCDSiCCDS84029.1
PIRiI49656
RefSeqiNP_001334443.1, NM_001347514.1
XP_006517153.1, XM_006517090.2
XP_017170871.1, XM_017315382.1
UniGeneiMm.126106
Mm.465019

Genome annotation databases

EnsembliENSMUST00000163091; ENSMUSP00000124406; ENSMUSG00000021461
GeneIDi14088
KEGGimmu:14088
UCSCiuc007qxt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFANCC_MOUSE
AccessioniPrimary (citable) accession number: P50652
Secondary accession number(s): E9PXX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome