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Protein

Fanconi anemia group C protein homolog

Gene

Fancc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity).By similarity

GO - Biological processi

  1. gamete generation Source: MGI
  2. germ cell development Source: MGI
  3. myeloid cell homeostasis Source: MGI
  4. nucleotide-excision repair Source: MGI
  5. removal of superoxide radicals Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

ReactomeiREACT_290303. Fanconi Anemia pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group C protein homolog
Short name:
Protein FACC
Gene namesi
Name:Fancc
Synonyms:Fac, Facc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:95480. Fancc.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: The major form is nuclear. The minor form is cytoplasmic.

GO - Cellular componenti

  1. cytosol Source: MGI
  2. Fanconi anaemia nuclear complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Fanconi anemia group C protein homologPRO_0000087185Add
BLAST

Proteomic databases

PaxDbiP50652.
PRIDEiP50652.

PTM databases

PhosphoSiteiP50652.

Expressioni

Tissue specificityi

Ubiquitous.

Developmental stagei

Embryos from days 8-13 show a uniform pattern of expression with somewhat higher level expression in days 8 and 9 in the head mesenchyme as compared to the rest of the embryo. Higher levels of expression are seen in the developing bones of 14 to 16 day embryos. In the 15 day embryo it is detected in the perichondrium and the marrow of the iliac bone and perichondrium of the ribs and vertebrae. In the 16 day embryo it is detected in the perichondrial layer of the developing digits of the forelimb, outer root sheath of the hair follicles of the upper jaw and in the perichondrium of the vertebrae.

Gene expression databases

BgeeiP50652.
CleanExiMM_FANCC.
ExpressionAtlasiP50652. baseline and differential.
GenevestigatoriP50652.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70. Interacts with ZBTB32. Upon IFNG induction, interacts with STAT1. Interacts with CDK1. Interacts with EIF2AK2 (By similarity).By similarity

Protein-protein interaction databases

IntActiP50652. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP50652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG44530.
GeneTreeiENSGT00390000016390.
HOGENOMiHOG000043097.
HOVERGENiHBG051548.
InParanoidiP50652.
KOiK10890.
OMAiVCLWLRH.
OrthoDBiEOG7RNK0K.

Family and domain databases

InterProiIPR000686. Fanconi.
[Graphical view]
PANTHERiPTHR16798. PTHR16798. 1 hit.
PfamiPF02106. Fanconi_C. 2 hits.
[Graphical view]
PIRSFiPIRSF018417. FACC_protein. 1 hit.
PRINTSiPR00494. FANCONICGENE.

Sequencei

Sequence statusi: Complete.

P50652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQESADLAS DCQSWLQKLS AWEQASSEET QKDTCLHLSG FQEFLRQMYE
60 70 80 90 100
ILKEMDSDAI LERFPTIGQL LAKACWNPLI LAYDESQKIV IWCLCCLMNK
110 120 130 140 150
EPRTSAESGL NSWIRGLLSH VLSAFRFDMK EVCLFTKSLG YESIDYYPSL
160 170 180 190 200
LKNMVLSLVS ELRESHLNGL STQSRMAPER MMSLSEVCVP LVTLPDMEPL
210 220 230 240 250
VEALLTYHGH EPQEVLAPEF FEAVNEAFLS EKIVLPTSSV VSLWFRHLPS
260 270 280 290 300
LEKATLHLFE KLFSSKIICL RRMECCIRES FLPQAACQPA IFRIVDEMFR
310 320 330 340 350
FVLLETDGAP EVLAALQVFT SCLVEALKKE NKQLTFALRT YFPYGAPCLA
360 370 380 390 400
AALSQHPEAI PQGHRLQPLL HISQLLREAV EDCTRGSPRN PFESWFLFVH
410 420 430 440 450
FGGWVDLAVA ELLLREEAEP PAGLLWLLVF YYSPQDGSQQ REQSMVELKV
460 470 480 490 500
LINRLLMLLR SGPLSATDLQ EAAESPSGDP RPPVCGQLVR RLLLSLLLWT
510 520 530 540 550
PEGHAIVWEA VTHGPTFEIT GPGCCPRIWR STRPQHRPRA HLCCTEMAHT
560 570 580 590
DAVIHEIIGF LDQTLYRSQH LCVEASRKLA RDLLKELQAQ V
Length:591
Mass (Da):66,979
Last modified:July 26, 2011 - v2
Checksum:i97DA796F55D8A68A
GO

Sequence cautioni

The sequence AAA37590.1 differs from that shown.Aberrant splicing.Curated
The sequence AAA37590.1 differs from that shown. Reason: Frameshift at position 81. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti235 – 2351L → V in AAA37590 (PubMed:7689006).Curated
Sequence conflicti296 – 2961D → H in AAA37590 (PubMed:7689006).Curated
Sequence conflicti305 – 3051E → K in AAA37590 (PubMed:7689006).Curated
Sequence conflicti533 – 5331R → K in AAA37590 (PubMed:7689006).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08266 mRNA. Translation: AAA37590.1. Sequence problems.
AC130827 Genomic DNA. No translation available.
AC154638 Genomic DNA. No translation available.
PIRiI49656.
RefSeqiXP_006517152.1. XM_006517089.2.
XP_006517153.1. XM_006517090.1.
UniGeneiMm.126106.

Genome annotation databases

EnsembliENSMUST00000163091; ENSMUSP00000124406; ENSMUSG00000021461.
GeneIDi14088.
KEGGimmu:14088.
UCSCiuc007qxt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08266 mRNA. Translation: AAA37590.1. Sequence problems.
AC130827 Genomic DNA. No translation available.
AC154638 Genomic DNA. No translation available.
PIRiI49656.
RefSeqiXP_006517152.1. XM_006517089.2.
XP_006517153.1. XM_006517090.1.
UniGeneiMm.126106.

3D structure databases

ProteinModelPortaliP50652.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP50652. 4 interactions.

PTM databases

PhosphoSiteiP50652.

Proteomic databases

PaxDbiP50652.
PRIDEiP50652.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163091; ENSMUSP00000124406; ENSMUSG00000021461.
GeneIDi14088.
KEGGimmu:14088.
UCSCiuc007qxt.1. mouse.

Organism-specific databases

CTDi2176.
MGIiMGI:95480. Fancc.

Phylogenomic databases

eggNOGiNOG44530.
GeneTreeiENSGT00390000016390.
HOGENOMiHOG000043097.
HOVERGENiHBG051548.
InParanoidiP50652.
KOiK10890.
OMAiVCLWLRH.
OrthoDBiEOG7RNK0K.

Enzyme and pathway databases

ReactomeiREACT_290303. Fanconi Anemia pathway.

Miscellaneous databases

PROiP50652.
SOURCEiSearch...

Gene expression databases

BgeeiP50652.
CleanExiMM_FANCC.
ExpressionAtlasiP50652. baseline and differential.
GenevestigatoriP50652.

Family and domain databases

InterProiIPR000686. Fanconi.
[Graphical view]
PANTHERiPTHR16798. PTHR16798. 1 hit.
PfamiPF02106. Fanconi_C. 2 hits.
[Graphical view]
PIRSFiPIRSF018417. FACC_protein. 1 hit.
PRINTSiPR00494. FANCONICGENE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and analysis of the murine Fanconi anemia group C cDNA."
    Wevrick R., Clarke C.A., Buchwald M.
    Hum. Mol. Genet. 2:655-662(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFANCC_MOUSE
AccessioniPrimary (citable) accession number: P50652
Secondary accession number(s): E9PXX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1996
Last sequence update: July 26, 2011
Last modified: March 31, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.