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P50652

- FANCC_MOUSE

UniProt

P50652 - FANCC_MOUSE

Protein

Fanconi anemia group C protein homolog

Gene

Fancc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 By similarity.By similarity

    GO - Biological processi

    1. gamete generation Source: MGI
    2. germ cell development Source: MGI
    3. myeloid cell homeostasis Source: MGI
    4. nucleotide-excision repair Source: MGI
    5. removal of superoxide radicals Source: MGI

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fanconi anemia group C protein homolog
    Short name:
    Protein FACC
    Gene namesi
    Name:Fancc
    Synonyms:Fac, Facc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:95480. Fancc.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: The major form is nuclear. The minor form is cytoplasmic.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. Fanconi anaemia nuclear complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591Fanconi anemia group C protein homologPRO_0000087185Add
    BLAST

    Proteomic databases

    PaxDbiP50652.
    PRIDEiP50652.

    PTM databases

    PhosphoSiteiP50652.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Developmental stagei

    Embryos from days 8-13 show a uniform pattern of expression with somewhat higher level expression in days 8 and 9 in the head mesenchyme as compared to the rest of the embryo. Higher levels of expression are seen in the developing bones of 14 to 16 day embryos. In the 15 day embryo it is detected in the perichondrium and the marrow of the iliac bone and perichondrium of the ribs and vertebrae. In the 16 day embryo it is detected in the perichondrial layer of the developing digits of the forelimb, outer root sheath of the hair follicles of the upper jaw and in the perichondrium of the vertebrae.

    Gene expression databases

    ArrayExpressiP50652.
    BgeeiP50652.
    CleanExiMM_FANCC.
    GenevestigatoriP50652.

    Interactioni

    Subunit structurei

    Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70. Interacts with ZBTB32. Upon IFNG induction, interacts with STAT1. Interacts with CDK1. Interacts with EIF2AK2 By similarity.By similarity

    Protein-protein interaction databases

    IntActiP50652. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP50652.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG44530.
    GeneTreeiENSGT00390000016390.
    HOGENOMiHOG000043097.
    HOVERGENiHBG051548.
    InParanoidiP50652.
    KOiK10890.
    OMAiVCLWLRH.
    OrthoDBiEOG7RNK0K.

    Family and domain databases

    InterProiIPR000686. Fanconi.
    [Graphical view]
    PANTHERiPTHR16798. PTHR16798. 1 hit.
    PfamiPF02106. Fanconi_C. 2 hits.
    [Graphical view]
    PIRSFiPIRSF018417. FACC_protein. 1 hit.
    PRINTSiPR00494. FANCONICGENE.

    Sequencei

    Sequence statusi: Complete.

    P50652-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQESADLAS DCQSWLQKLS AWEQASSEET QKDTCLHLSG FQEFLRQMYE    50
    ILKEMDSDAI LERFPTIGQL LAKACWNPLI LAYDESQKIV IWCLCCLMNK 100
    EPRTSAESGL NSWIRGLLSH VLSAFRFDMK EVCLFTKSLG YESIDYYPSL 150
    LKNMVLSLVS ELRESHLNGL STQSRMAPER MMSLSEVCVP LVTLPDMEPL 200
    VEALLTYHGH EPQEVLAPEF FEAVNEAFLS EKIVLPTSSV VSLWFRHLPS 250
    LEKATLHLFE KLFSSKIICL RRMECCIRES FLPQAACQPA IFRIVDEMFR 300
    FVLLETDGAP EVLAALQVFT SCLVEALKKE NKQLTFALRT YFPYGAPCLA 350
    AALSQHPEAI PQGHRLQPLL HISQLLREAV EDCTRGSPRN PFESWFLFVH 400
    FGGWVDLAVA ELLLREEAEP PAGLLWLLVF YYSPQDGSQQ REQSMVELKV 450
    LINRLLMLLR SGPLSATDLQ EAAESPSGDP RPPVCGQLVR RLLLSLLLWT 500
    PEGHAIVWEA VTHGPTFEIT GPGCCPRIWR STRPQHRPRA HLCCTEMAHT 550
    DAVIHEIIGF LDQTLYRSQH LCVEASRKLA RDLLKELQAQ V 591
    Length:591
    Mass (Da):66,979
    Last modified:July 27, 2011 - v2
    Checksum:i97DA796F55D8A68A
    GO

    Sequence cautioni

    The sequence AAA37590.1 differs from that shown. Reason: Aberrant splicing.
    The sequence AAA37590.1 differs from that shown. Reason: Frameshift at position 81.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti235 – 2351L → V in AAA37590. (PubMed:7689006)Curated
    Sequence conflicti296 – 2961D → H in AAA37590. (PubMed:7689006)Curated
    Sequence conflicti305 – 3051E → K in AAA37590. (PubMed:7689006)Curated
    Sequence conflicti533 – 5331R → K in AAA37590. (PubMed:7689006)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08266 mRNA. Translation: AAA37590.1. Sequence problems.
    AC130827 Genomic DNA. No translation available.
    AC154638 Genomic DNA. No translation available.
    PIRiI49656.
    RefSeqiXP_006517152.1. XM_006517089.1.
    XP_006517153.1. XM_006517090.1.
    XP_006517154.1. XM_006517091.1.
    XP_006517155.1. XM_006517092.1.
    UniGeneiMm.126106.

    Genome annotation databases

    EnsembliENSMUST00000163091; ENSMUSP00000124406; ENSMUSG00000021461.
    GeneIDi14088.
    KEGGimmu:14088.
    UCSCiuc007qxt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08266 mRNA. Translation: AAA37590.1 . Sequence problems.
    AC130827 Genomic DNA. No translation available.
    AC154638 Genomic DNA. No translation available.
    PIRi I49656.
    RefSeqi XP_006517152.1. XM_006517089.1.
    XP_006517153.1. XM_006517090.1.
    XP_006517154.1. XM_006517091.1.
    XP_006517155.1. XM_006517092.1.
    UniGenei Mm.126106.

    3D structure databases

    ProteinModelPortali P50652.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P50652. 4 interactions.

    PTM databases

    PhosphoSitei P50652.

    Proteomic databases

    PaxDbi P50652.
    PRIDEi P50652.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000163091 ; ENSMUSP00000124406 ; ENSMUSG00000021461 .
    GeneIDi 14088.
    KEGGi mmu:14088.
    UCSCi uc007qxt.1. mouse.

    Organism-specific databases

    CTDi 2176.
    MGIi MGI:95480. Fancc.

    Phylogenomic databases

    eggNOGi NOG44530.
    GeneTreei ENSGT00390000016390.
    HOGENOMi HOG000043097.
    HOVERGENi HBG051548.
    InParanoidi P50652.
    KOi K10890.
    OMAi VCLWLRH.
    OrthoDBi EOG7RNK0K.

    Miscellaneous databases

    PROi P50652.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P50652.
    Bgeei P50652.
    CleanExi MM_FANCC.
    Genevestigatori P50652.

    Family and domain databases

    InterProi IPR000686. Fanconi.
    [Graphical view ]
    PANTHERi PTHR16798. PTHR16798. 1 hit.
    Pfami PF02106. Fanconi_C. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF018417. FACC_protein. 1 hit.
    PRINTSi PR00494. FANCONICGENE.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and analysis of the murine Fanconi anemia group C cDNA."
      Wevrick R., Clarke C.A., Buchwald M.
      Hum. Mol. Genet. 2:655-662(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiFANCC_MOUSE
    AccessioniPrimary (citable) accession number: P50652
    Secondary accession number(s): E9PXX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3