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P50652 (FANCC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fanconi anemia group C protein homolog

Short name=Protein FACC
Gene names
Name:Fancc
Synonyms:Fac, Facc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 By similarity.

Subunit structure

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70. Interacts with ZBTB32. Upon IFNG induction, interacts with STAT1. Interacts with CDK1. Interacts with EIF2AK2 By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: The major form is nuclear. The minor form is cytoplasmic.

Tissue specificity

Ubiquitous.

Developmental stage

Embryos from days 8-13 show a uniform pattern of expression with somewhat higher level expression in days 8 and 9 in the head mesenchyme as compared to the rest of the embryo. Higher levels of expression are seen in the developing bones of 14 to 16 day embryos. In the 15 day embryo it is detected in the perichondrium and the marrow of the iliac bone and perichondrium of the ribs and vertebrae. In the 16 day embryo it is detected in the perichondrial layer of the developing digits of the forelimb, outer root sheath of the hair follicles of the upper jaw and in the perichondrium of the vertebrae.

Sequence caution

The sequence AAA37590.1 differs from that shown. Reason: Frameshift at position 81.

The sequence AAA37590.1 differs from that shown. Reason: Aberrant splicing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591Fanconi anemia group C protein homolog
PRO_0000087185

Experimental info

Sequence conflict2351L → V in AAA37590. Ref.1
Sequence conflict2961D → H in AAA37590. Ref.1
Sequence conflict3051E → K in AAA37590. Ref.1
Sequence conflict5331R → K in AAA37590. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P50652 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 97DA796F55D8A68A

FASTA59166,979
        10         20         30         40         50         60 
MAQESADLAS DCQSWLQKLS AWEQASSEET QKDTCLHLSG FQEFLRQMYE ILKEMDSDAI 

        70         80         90        100        110        120 
LERFPTIGQL LAKACWNPLI LAYDESQKIV IWCLCCLMNK EPRTSAESGL NSWIRGLLSH 

       130        140        150        160        170        180 
VLSAFRFDMK EVCLFTKSLG YESIDYYPSL LKNMVLSLVS ELRESHLNGL STQSRMAPER 

       190        200        210        220        230        240 
MMSLSEVCVP LVTLPDMEPL VEALLTYHGH EPQEVLAPEF FEAVNEAFLS EKIVLPTSSV 

       250        260        270        280        290        300 
VSLWFRHLPS LEKATLHLFE KLFSSKIICL RRMECCIRES FLPQAACQPA IFRIVDEMFR 

       310        320        330        340        350        360 
FVLLETDGAP EVLAALQVFT SCLVEALKKE NKQLTFALRT YFPYGAPCLA AALSQHPEAI 

       370        380        390        400        410        420 
PQGHRLQPLL HISQLLREAV EDCTRGSPRN PFESWFLFVH FGGWVDLAVA ELLLREEAEP 

       430        440        450        460        470        480 
PAGLLWLLVF YYSPQDGSQQ REQSMVELKV LINRLLMLLR SGPLSATDLQ EAAESPSGDP 

       490        500        510        520        530        540 
RPPVCGQLVR RLLLSLLLWT PEGHAIVWEA VTHGPTFEIT GPGCCPRIWR STRPQHRPRA 

       550        560        570        580        590 
HLCCTEMAHT DAVIHEIIGF LDQTLYRSQH LCVEASRKLA RDLLKELQAQ V 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08266 mRNA. Translation: AAA37590.1. Sequence problems.
AC130827 Genomic DNA. No translation available.
AC154638 Genomic DNA. No translation available.
PIRI49656.
RefSeqXP_006517152.1. XM_006517089.1.
XP_006517153.1. XM_006517090.1.
XP_006517154.1. XM_006517091.1.
XP_006517155.1. XM_006517092.1.
UniGeneMm.126106.

3D structure databases

ProteinModelPortalP50652.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP50652. 4 interactions.

PTM databases

PhosphoSiteP50652.

Proteomic databases

PaxDbP50652.
PRIDEP50652.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000163091; ENSMUSP00000124406; ENSMUSG00000021461.
GeneID14088.
KEGGmmu:14088.
UCSCuc007qxt.1. mouse.

Organism-specific databases

CTD2176.
MGIMGI:95480. Fancc.

Phylogenomic databases

eggNOGNOG44530.
GeneTreeENSGT00390000016390.
HOGENOMHOG000043097.
HOVERGENHBG051548.
InParanoidP50652.
KOK10890.
OMAVCLWLRH.
OrthoDBEOG7RNK0K.

Gene expression databases

ArrayExpressP50652.
BgeeP50652.
CleanExMM_FANCC.
GenevestigatorP50652.

Family and domain databases

InterProIPR000686. Fanconi.
[Graphical view]
PANTHERPTHR16798. PTHR16798. 1 hit.
PfamPF02106. Fanconi_C. 2 hits.
[Graphical view]
PIRSFPIRSF018417. FACC_protein. 1 hit.
PRINTSPR00494. FANCONICGENE.
ProtoNetSearch...

Other

PROP50652.
SOURCESearch...

Entry information

Entry nameFANCC_MOUSE
AccessionPrimary (citable) accession number: P50652
Secondary accession number(s): E9PXX6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot