Fanconi anemia group C protein homolog

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P50652 (FANCC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 84. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Fanconi anemia group C protein homolog
Short name=Protein FACC

Gene names

Name:	Fancc
Synonyms:	Fac, Facc

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	591 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 By similarity.
Subunit structure	Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70. Interacts with ZBTB32. Upon IFNG induction, interacts with STAT1. Interacts with CDK1. Interacts with EIF2AK2 By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Note: The major form is nuclear. The minor form is cytoplasmic.
Tissue specificity	Ubiquitous.
Developmental stage	Embryos from days 8-13 show a uniform pattern of expression with somewhat higher level expression in days 8 and 9 in the head mesenchyme as compared to the rest of the embryo. Higher levels of expression are seen in the developing bones of 14 to 16 day embryos. In the 15 day embryo it is detected in the perichondrium and the marrow of the iliac bone and perichondrium of the ribs and vertebrae. In the 16 day embryo it is detected in the perichondrial layer of the developing digits of the forelimb, outer root sheath of the hair follicles of the upper jaw and in the perichondrium of the vertebrae.
Sequence caution	The sequence AAA37590.1 differs from that shown. Reason: Frameshift at position 81. The sequence AAA37590.1 differs from that shown. Reason: Aberrant splicing.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	germ cell development Inferred from mutant phenotype PubMed 8704201. Source: MGI myeloid cell homeostasis Inferred from mutant phenotype PubMed 11493445. Source: MGI nucleotide-excision repair Inferred from mutant phenotype PubMed 8704201. Source: MGI removal of superoxide radicals Inferred from genetic interaction PubMed 11493445. Source: MGI
Cellular_component	Fanconi anaemia nuclear complex Inferred from sequence or structural similarity. Source: UniProtKB cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 591

591

Fanconi anemia group C protein homolog

PRO_0000087185

Experimental info

Sequence conflict

235

L → V in AAA37590. Ref.1

Sequence conflict

296

D → H in AAA37590. Ref.1

Sequence conflict

305

E → K in AAA37590. Ref.1

Sequence conflict

533

R → K in AAA37590. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P50652 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 97DA796F55D8A68A
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FASTA

591

66,979

        10         20         30         40         50         60 
MAQESADLAS DCQSWLQKLS AWEQASSEET QKDTCLHLSG FQEFLRQMYE ILKEMDSDAI 

        70         80         90        100        110        120 
LERFPTIGQL LAKACWNPLI LAYDESQKIV IWCLCCLMNK EPRTSAESGL NSWIRGLLSH 

       130        140        150        160        170        180 
VLSAFRFDMK EVCLFTKSLG YESIDYYPSL LKNMVLSLVS ELRESHLNGL STQSRMAPER 

       190        200        210        220        230        240 
MMSLSEVCVP LVTLPDMEPL VEALLTYHGH EPQEVLAPEF FEAVNEAFLS EKIVLPTSSV 

       250        260        270        280        290        300 
VSLWFRHLPS LEKATLHLFE KLFSSKIICL RRMECCIRES FLPQAACQPA IFRIVDEMFR 

       310        320        330        340        350        360 
FVLLETDGAP EVLAALQVFT SCLVEALKKE NKQLTFALRT YFPYGAPCLA AALSQHPEAI 

       370        380        390        400        410        420 
PQGHRLQPLL HISQLLREAV EDCTRGSPRN PFESWFLFVH FGGWVDLAVA ELLLREEAEP 

       430        440        450        460        470        480 
PAGLLWLLVF YYSPQDGSQQ REQSMVELKV LINRLLMLLR SGPLSATDLQ EAAESPSGDP 

       490        500        510        520        530        540 
RPPVCGQLVR RLLLSLLLWT PEGHAIVWEA VTHGPTFEIT GPGCCPRIWR STRPQHRPRA 

       550        560        570        580        590 
HLCCTEMAHT DAVIHEIIGF LDQTLYRSQH LCVEASRKLA RDLLKELQAQ V

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and analysis of the murine Fanconi anemia group C cDNA." Wevrick R., Clarke C.A., Buchwald M. Hum. Mol. Genet. 2:655-662(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Liver.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08266 mRNA. Translation: AAA37590.1. Sequence problems. AC130827 Genomic DNA. No translation available. AC154638 Genomic DNA. No translation available.
IPI	IPI00120362.
PIR	I49656.
UniGene	Mm.126106.
3D structure databases
ProteinModelPortal	P50652.
ModBase	Search...
Protein-protein interaction databases
IntAct	P50652. 4 interactions.
PTM databases
PhosphoSite	P50652.
Proteomic databases
PaxDb	P50652.
PRIDE	P50652.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000163091; ENSMUSP00000124406; ENSMUSG00000021461.
Organism-specific databases
MGI	MGI:95480. Fancc.
Phylogenomic databases
eggNOG	NOG44530.
GeneTree	ENSGT00390000016390.
HOGENOM	HOG000043097.
HOVERGEN	HBG051548.
InParanoid	P50652.
OMA	LKTYFPY.
Gene expression databases
ArrayExpress	P50652.
Bgee	P50652.
CleanEx	MM_FANCC.
Genevestigator	P50652.
GermOnline	ENSMUSG00000021461. Mus musculus.
Family and domain databases
InterPro	IPR000686. Fanconi. [Graphical view]
PANTHER	PTHR16798. PTHR16798. 1 hit.
Pfam	PF02106. Fanconi_C. 2 hits. [Graphical view]
PIRSF	PIRSF018417. FACC_protein. 1 hit.
PRINTS	PR00494. FANCONICGENE.
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

FANCC_MOUSE

Accession

Primary (citable) accession number: P50652
Secondary accession number(s): E9PXX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents