P50651Q9LUH0RIR2A_ARATHRibonucleoside-diphosphate reductase small chain A1.17.4.1Ribonucleoside-diphosphate reductase R2A subunitAtRNR2Protein R2atRibonucleotide reductase small subunit ARNR2ARNR2At3g23580MDB19.6Arabidopsis thalianaMouse-ear cressEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsisMolecular characterization and cell cycle-regulated expression of a cDNA clone from Arabidopsis thaliana homologous to the small subunit of ribonucleotide reductase.NUCLEOTIDE SEQUENCE [MRNA]DEVELOPMENTAL STAGEStructural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.GENOME REANNOTATIONEmpirical analysis of transcriptional activity in the Arabidopsis genome.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Ribonucleotide reductase from the higher plant Arabidopsis thaliana: expression of the R2 component and characterization of its iron-radical center.FUNCTIONCOFACTORSUBUNITReactivity studies of the tyrosyl radical in ribonucleotide reductase from Mycobacterium tuberculosis and Arabidopsis thaliana -- comparison with Escherichia coli and mouse.ACTIVITY REGULATIONArabidopsis ribonucleotide reductases are critical for cell cycle progression, DNA damage repair, and plant development.TISSUE SPECIFICITYFUNCTIONDISRUPTION PHENOTYPECOP9 signalosome subunit 7 from Arabidopsis interacts with and regulates the small subunit of ribonucleotide reductase (RNR2).INTERACTION WITH CSN7SUBUNITTISSUE SPECIFICITYProvides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphateFe cationBinds 2 iron ions per subunit.Inhibited by phenol, paracetamol, 2,4,6-trimethylphenol, resveratrol, furfuryl mercaptan, 2-thiophenthiol, phenylhydrazine, and hydroxyurea.Homodimer and heterodimer with TSO2. Heterotetramer of two R1 and two R2 chains. A radical transfer pathway may occur between Tyr-125 of protein R2 and R1. Homodimer contains a dinuclear non-heme iron center and a stable tyrosyl radical essential for activity. A transfer pathway may occur between Tyr-125 of protein R2 and R1. Interacts with CSN7.CytoplasmExpressed in rosette leaves, cauline leaves, stems and flowers.Accumulated during S phase of the cell cycle.No visible phenotype, due to the redundancy with RNR2B and TSO2. Rnr2a and rnr2b double mutants have no visible phenotype.A substrate-binding catalytic site, located on R1, is formed only in the presence of the second subunit R2.Belongs to the ribonucleoside diphosphate reductase small chain family.CytoplasmDeoxyribonucleotide synthesisIronMetal-bindingOxidoreductaseReference proteomeFe cationFe cationFe cationFe cationFe cationFe cationFe cationVAYIKQLLHVMGSLKEGQGRDMEEGESEEPLLMAQNQRFTMFPIRYKSIWEMYKKAEASFWTAEEVDLSTDVQQWEALTDSEKHFISHILAFFAASDGIVLENLAARFLNDVQVPEARAFYGFQIAMENIHSEMYSLLLETFIKDSKEKDRLFNAIETIPCISKKAKWCLDWIQSPMSFAVRLVAFACVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYSLLQKQLPLEKVYQIVHEAVEIETEFVCKALPCDLIGMNSNLMSQYIQFVADRLLVTLGCERTYKAENPFDWMEFISLQGKTNFFEKRVGEYQKASVMSNLQNGNQNYEFTTEEDF
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