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P50650

- RIR2_PLAF4

UniProt

P50650 - RIR2_PLAF4

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

RNR2

Organism
Plasmodium falciparum (isolate Dd2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi99 – 991Iron 1PROSITE-ProRule annotation
Metal bindingi130 – 1301Iron 1PROSITE-ProRule annotation
Metal bindingi130 – 1301Iron 2By similarity
Metal bindingi133 – 1331Iron 1PROSITE-ProRule annotation
Active sitei137 – 1371PROSITE-ProRule annotation
Metal bindingi192 – 1921Iron 2By similarity
Metal bindingi226 – 2261Iron 2By similarity
Metal bindingi229 – 2291Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase R2 subunit
Ribonucleotide reductase small subunit
Gene namesi
Name:RNR2
OrganismiPlasmodium falciparum (isolate Dd2)
Taxonomic identifieri57267 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Ribonucleoside-diphosphate reductase small chainPRO_0000190459Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Structurei

3D structure databases

ProteinModelPortaliP50650.
SMRiP50650. Positions 18-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50650-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADVINISRI PIFSKQEREF SDLQKGKEIN EKILNKESDR FTLYPILYPD
60 70 80 90 100
VWDFYKKAEA SFWTAEEIDL SSDLKDFEKL NENEKHFIKH VLAFFAASDG
110 120 130 140 150
IVLENLASKF LREVQITEAK KFYSFQIAVE NIHSETYSLL IDNYIKDEKE
160 170 180 190 200
RLNLFHAIEN IPAVKNKALW AAKWINDTNS FAERIVANAC VEGILFSGSF
210 220 230 240 250
CAIFWFKKQN KLHGLTFSNE LISRDEGLHT DFNCLIYSLL DNKLPEQIIQ
260 270 280 290 300
NIVKEAVEVE RSFICESLPC DLIGMNSRLM SQYIEFVADR LLECLGCSKI
310 320 330 340
FHSKNPFNWM DLISLQGKTN FFEKRVADYQ KSGVMAQRKD QVFCLNTEF
Length:349
Mass (Da):40,595
Last modified:October 1, 1996 - v1
Checksum:iD21FE30B78F85889
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01322 mRNA. Translation: AAA50170.1.
PIRiB49412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01322 mRNA. Translation: AAA50170.1 .
PIRi B49412.

3D structure databases

ProteinModelPortali P50650.
SMRi P50650. Positions 18-312.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of subunit genes of ribonucleotide reductase, a cell-cycle-regulated enzyme, from Plasmodium falciparum."
    Chakrabarti D., Schuster S.M., Chakrabarti R.
    Proc. Natl. Acad. Sci. U.S.A. 90:12020-12024(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiRIR2_PLAF4
AccessioniPrimary (citable) accession number: P50650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3