Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P50650 (RIR2_PLAF4) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase R2 subunit
Ribonucleotide reductase small subunit
Gene names
Name:RNR2
OrganismPlasmodium falciparum (isolate Dd2)
Taxonomic identifier57267 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small subunit.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Ribonucleoside-diphosphate reductase small chain
PRO_0000190459

Sites

Active site1371 By similarity
Metal binding991Iron 1 By similarity
Metal binding1301Iron 1 By similarity
Metal binding1301Iron 2 By similarity
Metal binding1331Iron 1 By similarity
Metal binding1921Iron 2 By similarity
Metal binding2261Iron 2 By similarity
Metal binding2291Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P50650 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D21FE30B78F85889

FASTA34940,595
        10         20         30         40         50         60 
MADVINISRI PIFSKQEREF SDLQKGKEIN EKILNKESDR FTLYPILYPD VWDFYKKAEA 

        70         80         90        100        110        120 
SFWTAEEIDL SSDLKDFEKL NENEKHFIKH VLAFFAASDG IVLENLASKF LREVQITEAK 

       130        140        150        160        170        180 
KFYSFQIAVE NIHSETYSLL IDNYIKDEKE RLNLFHAIEN IPAVKNKALW AAKWINDTNS 

       190        200        210        220        230        240 
FAERIVANAC VEGILFSGSF CAIFWFKKQN KLHGLTFSNE LISRDEGLHT DFNCLIYSLL 

       250        260        270        280        290        300 
DNKLPEQIIQ NIVKEAVEVE RSFICESLPC DLIGMNSRLM SQYIEFVADR LLECLGCSKI 

       310        320        330        340 
FHSKNPFNWM DLISLQGKTN FFEKRVADYQ KSGVMAQRKD QVFCLNTEF 

« Hide

References

[1]"Cloning and characterization of subunit genes of ribonucleotide reductase, a cell-cycle-regulated enzyme, from Plasmodium falciparum."
Chakrabarti D., Schuster S.M., Chakrabarti R.
Proc. Natl. Acad. Sci. U.S.A. 90:12020-12024(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U01322 mRNA. Translation: AAA50170.1.
PIRB49412.

3D structure databases

ProteinModelPortalP50650.
SMRP50650. Positions 18-312.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_PLAF4
AccessionPrimary (citable) accession number: P50650
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 11, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways