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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

RNR2

Organism
Plasmodium falciparum (isolate Dd2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathway: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi99 – 991Iron 1PROSITE-ProRule annotation
Metal bindingi130 – 1301Iron 1PROSITE-ProRule annotation
Metal bindingi130 – 1301Iron 2By similarity
Metal bindingi133 – 1331Iron 1PROSITE-ProRule annotation
Active sitei137 – 1371PROSITE-ProRule annotation
Metal bindingi192 – 1921Iron 2By similarity
Metal bindingi226 – 2261Iron 2By similarity
Metal bindingi229 – 2291Iron 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase R2 subunit
Ribonucleotide reductase small subunit
Gene namesi
Name:RNR2
OrganismiPlasmodium falciparum (isolate Dd2)
Taxonomic identifieri57267 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Ribonucleoside-diphosphate reductase small chainPRO_0000190459Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Protein-protein interaction databases

STRINGi5833.PF14_0053.

Structurei

3D structure databases

ProteinModelPortaliP50650.
SMRiP50650. Positions 18-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
IPR030475. RNR_small_AS.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P50650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVINISRI PIFSKQEREF SDLQKGKEIN EKILNKESDR FTLYPILYPD
60 70 80 90 100
VWDFYKKAEA SFWTAEEIDL SSDLKDFEKL NENEKHFIKH VLAFFAASDG
110 120 130 140 150
IVLENLASKF LREVQITEAK KFYSFQIAVE NIHSETYSLL IDNYIKDEKE
160 170 180 190 200
RLNLFHAIEN IPAVKNKALW AAKWINDTNS FAERIVANAC VEGILFSGSF
210 220 230 240 250
CAIFWFKKQN KLHGLTFSNE LISRDEGLHT DFNCLIYSLL DNKLPEQIIQ
260 270 280 290 300
NIVKEAVEVE RSFICESLPC DLIGMNSRLM SQYIEFVADR LLECLGCSKI
310 320 330 340
FHSKNPFNWM DLISLQGKTN FFEKRVADYQ KSGVMAQRKD QVFCLNTEF
Length:349
Mass (Da):40,595
Last modified:October 1, 1996 - v1
Checksum:iD21FE30B78F85889
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01322 mRNA. Translation: AAA50170.1.
PIRiB49412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01322 mRNA. Translation: AAA50170.1.
PIRiB49412.

3D structure databases

ProteinModelPortaliP50650.
SMRiP50650. Positions 18-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5833.PF14_0053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
IPR030475. RNR_small_AS.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of subunit genes of ribonucleotide reductase, a cell-cycle-regulated enzyme, from Plasmodium falciparum."
    Chakrabarti D., Schuster S.M., Chakrabarti R.
    Proc. Natl. Acad. Sci. U.S.A. 90:12020-12024(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiRIR2_PLAF4
AccessioniPrimary (citable) accession number: P50650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.