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P50650

- RIR2_PLAF4

UniProt

P50650 - RIR2_PLAF4

Protein

Ribonucleoside-diphosphate reductase small chain

Gene

RNR2

Organism
Plasmodium falciparum (isolate Dd2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi99 – 991Iron 1PROSITE-ProRule annotation
    Metal bindingi130 – 1301Iron 1PROSITE-ProRule annotation
    Metal bindingi130 – 1301Iron 2By similarity
    Metal bindingi133 – 1331Iron 1PROSITE-ProRule annotation
    Active sitei137 – 1371PROSITE-ProRule annotation
    Metal bindingi192 – 1921Iron 2By similarity
    Metal bindingi226 – 2261Iron 2By similarity
    Metal bindingi229 – 2291Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase R2 subunit
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:RNR2
    OrganismiPlasmodium falciparum (isolate Dd2)
    Taxonomic identifieri57267 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Ribonucleoside-diphosphate reductase small chainPRO_0000190459Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small subunit.

    Structurei

    3D structure databases

    ProteinModelPortaliP50650.
    SMRiP50650. Positions 18-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P50650-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADVINISRI PIFSKQEREF SDLQKGKEIN EKILNKESDR FTLYPILYPD    50
    VWDFYKKAEA SFWTAEEIDL SSDLKDFEKL NENEKHFIKH VLAFFAASDG 100
    IVLENLASKF LREVQITEAK KFYSFQIAVE NIHSETYSLL IDNYIKDEKE 150
    RLNLFHAIEN IPAVKNKALW AAKWINDTNS FAERIVANAC VEGILFSGSF 200
    CAIFWFKKQN KLHGLTFSNE LISRDEGLHT DFNCLIYSLL DNKLPEQIIQ 250
    NIVKEAVEVE RSFICESLPC DLIGMNSRLM SQYIEFVADR LLECLGCSKI 300
    FHSKNPFNWM DLISLQGKTN FFEKRVADYQ KSGVMAQRKD QVFCLNTEF 349
    Length:349
    Mass (Da):40,595
    Last modified:October 1, 1996 - v1
    Checksum:iD21FE30B78F85889
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01322 mRNA. Translation: AAA50170.1.
    PIRiB49412.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01322 mRNA. Translation: AAA50170.1 .
    PIRi B49412.

    3D structure databases

    ProteinModelPortali P50650.
    SMRi P50650. Positions 18-312.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of subunit genes of ribonucleotide reductase, a cell-cycle-regulated enzyme, from Plasmodium falciparum."
      Chakrabarti D., Schuster S.M., Chakrabarti R.
      Proc. Natl. Acad. Sci. U.S.A. 90:12020-12024(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiRIR2_PLAF4
    AccessioniPrimary (citable) accession number: P50650
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3